World's Best Scientists 2026 revealed!

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Chemistry

D-Index
57
Citations
12643
World Ranking
11015
National Ranking
3012

Biology and Biochemistry

D-Index
61
Citations
13435
World Ranking
11342
National Ranking
4912

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1995 - Fellow of the Royal Society, United Kingdom

Overview

Jack H. Kaplan is affiliated with the University of Illinois at Chicago in the United States.

Their research spans several fields, primarily focusing on physiology, cellular and molecular neuroscience, nutrition and dietetics, immunology, and molecular biology. Key topics explored in their work include nuclear receptors and signaling, trace elements in health, Alzheimer's disease research and treatments, adenosine and purinergic signaling, microRNA in disease regulation, biomarkers in disease mechanisms, and cell adhesion molecules research.

Kaplan has contributed to numerous publications, with recent papers including:

  • "Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis" (2022) published in Nature Cell Biology
  • "The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2" (2021) published in Nature Communications
  • "Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis" (2022) published in Cells
  • "Altered copper transport in oxidative stress-dependent brain endothelial barrier dysfunction associated with Alzheimer's disease" (2024) published in Vascular Pharmacology
  • "Abstract 12879: Endothelial Cu Exporter Atp7a Deficiency Promotes Cu-Dependent Endothelial-to-Mesenchymal Transition and Atherosclerosis via Orchestrating Glycolysis and Ros Signaling" (2022) published in Circulation

The scientist frequently collaborates with other researchers, including Sudhahar Varadarajan, Masuko Ushio-Fukai, Tohru Fukai, Archita Das, and Dipankar Ash.

Their work often appears in journals such as Circulation, Free Radical Biology and Medicine, Nature Cell Biology, Nature Communications, and Cells.

Jack H. Kaplan has received recognition through several awards, notably being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2014 and a Fellow of the Royal Society, United Kingdom, in 1995.

Best Publications

  • Biochemistry of Na,K-ATPase

    Jack H. Kaplan

  • Rapid photolytic release of adenosine 5'-triphosphate from a protected analogue: utilization by the Na:K pump of human red blood cell ghosts.

    Jack H. Kaplan;Bliss Forbush;Joseph F. Hoffman

  • Organization of P-type ATPases: significance of structural diversity.

    Svetlana Lutsenko;Jack H. Kaplan

  • Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

    H. H. Valdivia;J. H. Kaplan;G. C. R. Ellis-Davies;W. J. Lederer

  • Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions

    Konstantin Petrukhin;Svetiana Lutsenko;Igor Chernov;Barbara M. Ross

  • De novo design of catalytic proteins

    J. Kaplan;W. F. DeGrado

  • Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the Na, K-ATPase.

    Bliss Forbush;Jack H. Kaplan;Joseph F. Hoffman

  • Photolabile chelators for the rapid photorelease of divalent cations.

    Jack H. Kaplan;Graham C. R. Ellis-Davies

  • Nitrophenyl-EGTA, a photolabile chelator that selectively binds Ca2+ with high affinity and releases it rapidly upon photolysis.

    Graham C. R. Ellis-Davies;Jack H. Kaplan

  • N-terminal Domains of Human Copper-transporting Adenosine Triphosphatases (the Wilson’s and Menkes Disease Proteins) Bind Copper Selectively in Vivo and in Vitro with Stoichiometry of One Copper Per Metal-binding Repeat

    Svetlana Lutsenko;Konstantin Petrukhin;Matthew J. Cooper;Conrad T. Gilliam

  • Na+/Ca2+ exchange and Na+/K+-ATPase in the heart.

    Michael J. Shattock;Michela Ottolia;Donald M. Bers;Mordecai P. Blaustein

  • How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal

    Jack H. Kaplan;Edward B. Maryon

  • Molecular Characterization of hCTR1, the Human Copper Uptake Protein

    John F. Eisses;Jack H. Kaplan

  • Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1

    Edward B. Maryon;Shannon A. Molloy;Jack H. Kaplan

  • An essential role for the extracellular domain of the Na,K-ATPase β-subunit in cation occlusion

    Svetlana Lutsenko;Jack H. Kaplan

  • Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis

    Unknown

  • Copper transporters and copper chaperones: roles in cardiovascular physiology and disease.

    Tohru Fukai;Tohru Fukai;Masuko Ushio-Fukai;Jack H. Kaplan

  • Copper transport in mammalian cells: special care for a metal with special needs.

    Jack H. Kaplan;Svetlana Lutsenko

  • The mechanism of copper uptake mediated by human CTR1: a mutational analysis.

    John F. Eisses;Jack H. Kaplan

  • Chemical modification as an approach to elucidation of sodium pump structure-function relations.

    C. H. Pedemonte;J. H. Kaplan

  • Laser photolysis of caged calcium: rates of calcium release by nitrophenyl-EGTA and DM-nitrophen

    G. C. R. Ellis-Davies;J. H. Kaplan;Robert J. Barsotti

Frequent Co-Authors

Svetlana Lutsenko
Svetlana Lutsenko Johns Hopkins University
Tohru Fukai
Tohru Fukai Veterans Health Administration
George Sachs
George Sachs University of California, Los Angeles
Ninian J. Blackburn
Ninian J. Blackburn Oregon Health & Science University
Youngmee Kim
Youngmee Kim University of Miami
Mordecai P. Blaustein
Mordecai P. Blaustein University of Maryland, Baltimore
Masuko Ushio-Fukai
Masuko Ushio-Fukai Augusta University
Ernst Bamberg
Ernst Bamberg Max Planck Society
Lester F. Lau
Lester F. Lau University of Illinois at Chicago
Dennis R. Grayson
Dennis R. Grayson University of Illinois at Chicago

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