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Biology and Biochemistry

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52
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16445
National Ranking
574

Overview

Annik Prat is a researcher affiliated with the University of Montreal in Canada. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology. Within these broader fields, their work spans several specialized subfields, including surgery, molecular biology, immunology, oncology, and immunology and allergy.

Their investigations cover a diverse range of topics, with a particular focus on lipoproteins and cardiovascular health, atherosclerosis and cardiovascular diseases, cell adhesion molecules research, endoplasmic reticulum stress and disease, signaling pathways in disease, liver disease diagnosis and treatment, and hormonal and reproductive studies.

Annik Prat has contributed to several scientific publications, including:

  • "The Multifaceted Biology of PCSK9," 2021, Endocrine Reviews
  • "The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury," 2020, Journal of Clinical Investigation
  • "Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis," 2020, Clinical Biochemistry
  • "Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice," 2021, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • "PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis," 2022, Frontiers in Cell and Developmental Biology

Their research has appeared frequently in several academic journals, notably:

  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Journal of Lipid Research
  • Metabolism
  • Endocrine Reviews
  • Frontiers in Cell and Developmental Biology

Annik Prat collaborates with multiple co-authors who have contributed regularly to their research projects. Frequent collaborators include:

  • Nabil G. Seidah
  • Anna Roubtsova
  • Damien Garçon
  • Rachid Essalmani
  • Bertrand Cariou

Best Publications

  • The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

    Nabil G. Seidah;Suzanne Benjannet;Louise Wickham;Jadwiga Marcinkiewicz

  • Automated design of ligands to polypharmacological profiles

    Jérémy Besnard;Gian Filippo Ruda;Vincent Setola;Keren Abecassis

  • The biology and therapeutic targeting of the proprotein convertases

    Nabil G. Seidah;Annik Prat

  • NARC-1/PCSK9 and Its Natural Mutants ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL

    Suzanne Benjannet;David Rhainds;Rachid Essalmani;Janice Mayne

  • Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

    Geneviève Dubuc;Ann Chamberland;Hanny Wassef;Jean Davignon

  • The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

    Steve Poirier;Gaetan Mayer;Suzanne Benjannet;Eric Bergeron

  • Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) : Hepatocyte-Specific Low-Density Lipoprotein Receptor Degradation and Critical Role in Mouse Liver Regeneration

    Ahmed Zaid;Anna Roubtsova;Rachid Essalmani;Jadwiga Marcinkiewicz

  • In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

    Rachid Essalmani;Delia Susan-Resiga;Ann Chamberland;Marianne Abifadel

  • The activation and physiological functions of the proprotein convertases

    Nabil G. Seidah;Gaetan Mayer;Ahmed Zaid;Estelle Rousselet

  • Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.

    Kyeongdae Kim;Dahee Shim;Jun Seong Lee;Konstantin Zaitsev

  • Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation EVIDENCE FOR AN INTRACELLULAR ROUTE

    Steve Poirier;Gaetan Mayer;Viviane Poupon;Peter S. McPherson

  • Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue

    Anna Roubtsova;Mercedes Nancy Munkonda;Zuhier Awan;Jadwiga Marcinkiewicz

  • The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.

    Nasha Nassoury;Daniel A. Blasiole;Angie Tebon Oler;Suzanne Benjannet

  • Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

    Maxime Denis;Jadwiga Marcinkiewicz;Ahmed Zaid;Dany Gauthier

  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).

    Maryssa Canuel;Xiaowei Sun;Marie-Claude Asselin;Eustache Paramithiotis

  • The proprotein convertases are potential targets in the treatment of dyslipidemia

    Nabil G. Seidah;Annik Prat

  • Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.

    Abdel-Majid Khatib;Abdel-Majid Khatib;Géraldine Siegfried;Annik Prat;José Luis

  • Precursor convertases in the secretory pathway, cytosol and extracellular milieu.

    Nabil G Seidah;Annik Prat

  • PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

    Majambu Mbikay;Majambu Mbikay;Majambu Mbikay;Francine Sirois;Janice Mayne;Gen-Sheng Wang

  • ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL

    Suzanne Benjannet;David Rhainds;Rachid Essalmani;Janice Mayne

Frequent Co-Authors

Nabil G. Seidah
Nabil G. Seidah University of Montreal
Suzanne Benjannet
Suzanne Benjannet University of Montreal
Michel Chrétien
Michel Chrétien University of Montreal
Bertrand Cariou
Bertrand Cariou University of Nantes
Robert Day
Robert Day Université de Sherbrooke
Catherine Boileau
Catherine Boileau Université Paris Cité
Shoumo Bhattacharya
Shoumo Bhattacharya University of Oxford
Jean Davignon
Jean Davignon University of Montreal
Alan D. Attie
Alan D. Attie University of Wisconsin–Madison
Richard C. Austin
Richard C. Austin McMaster University

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