World's Best Scientists 2026 revealed!

Overview

Jacek Bielawski is affiliated with the Medical University of South Carolina in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields, including genetics, molecular biology, oncology, sociology and political science, and public health, environmental and occupational health.

The research conducted by Bielawski covers diverse topics, with notable focus areas including:

  • Evolution and Genetic Dynamics
  • Gut microbiota and health
  • Inflammatory Bowel Disease
  • Evolutionary Game Theory and Cooperation
  • Genomics and Phylogenetic Studies
  • Pancreatic and Hepatic Oncology Research
  • Plant and animal studies

The scientist has published in a variety of journals, with frequent contributions to:

  • Journal of Crohn's and Colitis
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cellular and Infection Microbiology
  • Molecular Biology and Evolution

Among the recent papers authored or co-authored by Bielawski are:

  • Bacterial Taxa and Functions Are Predictive of Sustained Remission Following Exclusive Enteral Nutrition in Pediatric Crohn's Disease (2020, Inflammatory Bowel Diseases)
  • Successful Dietary Therapy in Paediatric Crohn's Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards Healthy Controls (2022, Journal of Crohn's and Colitis)
  • The role of purifying selection in the origin and maintenance of complex function (2021, Studies in History and Philosophy of Science Part A)
  • Re-evaluating the relationship between missing heritability and the microbiome (2020, Microbiome)
  • Antibiotic and antifungal use in pediatric leukemia and lymphoma patients are associated with increasing opportunistic pathogens and decreasing bacteria responsible for activities that enhance colonic defense (2022, Frontiers in Cellular and Infection Microbiology)

Frequent co-authors collaborating with Bielawski include:

  • Katherine A. Dunn
  • Johan Van Limbergen
  • Edward Susko
  • Morgan G. I. Langille
  • Tamara MacDonald

Best Publications

  • Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

    Jacek Bielawski;Zdzislaw M. Szulc;Yusuf A. Hannun;Alicja Bielawska

  • The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α

    Benjamin J. Pettus;Jacek Bielawski;Anna M. Porcelli;Davis L. Reames

  • Blood sphingolipidomics in healthy humans: impact of sample collection methodology.

    Samar M. Hammad;Jason S. Pierce;Farzan Soodavar;Kent J. Smith

  • Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas *

    Serap Koybasi;Can E. Senkal;Kamala Sundararaj;Stefka Spassieva

  • Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α

    Yosuke Osawa;Hiroshi Uchinami;Jacek Bielawski;Robert F. Schwabe

  • PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

    Paolo Neviani;Jason G. Harb;Joshua J. Oaks;Ramasamy Santhanam

  • Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.

    Lihua Shi;Jacek Bielawski;Jinye Mu;Haili Dong

  • Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells

    Jacqueline M. Kraveka;Li Li;Zdzislaw M. Szulc;Jacek Bielawski

  • Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells

    Norma Marchesini;Walid Osta;Jacek Bielawski;Chiara Luberto

  • Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

    Charmi Shah;Guang Yang;Ian Lee;Jacek Bielawski

  • Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation

    Masayoshi Yamanaka;Daniel Shegogue;Heuping Pei;Shizhong Bu

  • Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis

    Tarek A. Taha;Kazuyuki Kitatani;Mazen El-Alwani;Mazen El-Alwani;Jacek Bielawski

  • The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.

    Benjamin James Pettus;Kazuyuki Kitatani;Charles E. Chalfant;Tarek A. Taha

  • Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids

    Mari Kono;Jennifer L. Dreier;Jessica M. Ellis;Maria L. Allende

  • Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

    Tarek A. Taha;Tarek A. Taha;Walid Osta;Lina Kozhaya;Jacek Bielawski

  • The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.

    Antonio F Saad;William D Meacham;Aiping Bai;Viviane Anelli

  • Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

    Dingding An;Chongzheng Na;Jacek Bielawski;Yusuf A. Hannun

  • Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer

    Ayman E.M. Mahdy;Joseph C. Cheng;Jun Li;Saeed Elojeimy

  • Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.

    Stefka Spassieva;Jae-Gu Seo;James C. Jiang;Jacek Bielawski

  • AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

    Junfei Jin;Junfei Jin;Thomas D. Mullen;Qi Hou;Qi Hou;Jacek Bielawski

Frequent Co-Authors

Curt R. Enzell
Curt R. Enzell Royal Institute of Technology
Noboru Yanaihara
Noboru Yanaihara University of Shizuoka

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