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Chemistry

D-Index
72
Citations
19626
World Ranking
5225
National Ranking
1627

Overview

Bruce E. Maryanoff is affiliated with Johnson & Johnson in the United States. Their primary research fields include chemistry, with a focus on organic chemistry, molecular biology, physiology, biological psychiatry, and computational theory and mathematics.

The scientist's research topics cover a range of interdisciplinary areas, including:

  • Gut microbiota and health
  • Diet and metabolism studies
  • Tryptophan and brain disorders
  • Click chemistry and applications
  • Computational drug discovery methods
  • Synthesis and biological activity

Bruce E. Maryanoff's recent publications include:

  • Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis, 2020, Nature Biotechnology
  • Presenting a Special Issue on "Medicinal Chemistry: From Targets to Therapies", 2020, ACS Medicinal Chemistry Letters

The venues where Maryanoff has published frequently are:

  • Nature Biotechnology
  • ACS Medicinal Chemistry Letters

Collaborations have been established with several co-authors across different areas of research, including:

  • Poshen B. Chen
  • Audrey S. Black
  • Adam L. Sobel
  • Yannan Zhao
  • Purba Mukherjee

Best Publications

  • The Wittig olefination reaction and modifications involving phosphoryl-stabilized carbanions. Stereochemistry, mechanism, and selected synthetic aspects

    Bruce E. Maryanoff;Allen B. Reitz

  • An overview of the preclinical aspects of topiramate : Pharmacology, pharmacokinetics, and mechanism of action

    Richard P. Shank;Joseph F. Gardocki;Anthony J. Streeter;Bruce E. Maryanoff

  • Cyclizations of N-acyliminium ions.

    Bruce E. Maryanoff;Han-Cheng Zhang;Judith H. Cohen;Ignatius J. Turchi

  • Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

    Richard P. Shank;Joseph F. Gardocki;Jeffry L. Vaught;Coralie B. Davis

  • Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes

    Susanna J. Dodgson;Richard P. Shank;Bruce E. Maryanoff

  • Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds.

    Bruce E. Maryanoff;Samuel O. Nortey;Joseph F. Gardocki;Richard P. Shank

  • Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

    Patricia Andrade-Gordon;Bruce E. Maryanoff;Claudia K. Derian;Han-Cheng Zhang

  • Selective deoxygenation of ketones and aldehydes including hindered systems with sodium cyanoborohydride

    Robert O. Hutchins;Cynthia A. Milewski;Bruce E. Maryanoff

  • Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates

    Claudia K. Derian;Bruce P. Damiano;Michael F. Addo;Andrew L. Darrow

  • Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.

    Bruce E. Maryanoff;David F. McComsey;Joseph F. Gardocki;Richard P. Shank

  • Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions

    Mabel A. Cejas;William A. Kinney;Cailin Chen;Jeremy G. Vinter

  • Stereochemistry of the Wittig reaction. Effect of nucleophilic groups in the phosphonium ylide

    Bruce E. Maryanoff;Allen B. Reitz;Barbara A. Duhl-Emswiler

  • Synthesis of Macrocycles via Cobalt-Mediated [2 + 2 + 2] Cycloadditions

    Llorente V R Boñaga;Han-Cheng Zhang;Alessandro F Moretto;Hong Ye

  • Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

    Bruce E. Maryanoff;Michael J. Costanzo;Samuel O. Nortey;Michael N. Greco

  • Facile solid-phase construction of indole derivatives based on a traceless, activating sulfonyl linker

    Han-Cheng Zhang;Hong Ye;Alessandro F. Moretto;Kimberly K. Brumfield

  • Molecular pharmacodynamics, clinical therapeutics, and pharmacokinetics of topiramate.

    Richard P. Shank;Bruce E. Maryanoff

  • Collagen-related peptides : Self-assembly of short, single strands into a functional biomaterial of micrometer scale

    Mabel A. Cejas;William A. Kinney;Cailin Chen;Gregory C. Leo

  • Deuterated Drug Molecules: Focus on FDA-Approved Deutetrabenazine

    Sheila H. DeWitt;Bruce E. Maryanoff

  • Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats

    Patricia Andrade-Gordon;Claudia K. Derian;Bruce E. Maryanoff;Han-Cheng Zhang

  • Stereochemistry and mechanism of the Wittig reaction. Diasteromeric reaction intermediates and analysis of the reaction course.

    Bruce E. Maryanoff;Allen B. Reitz;Martin S. Mutter;Robert R. Whittle

  • Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

    B E Maryanoff;X Qiu;K P Padmanabhan;A Tulinsky

Frequent Co-Authors

Kurt Mislow
Kurt Mislow Princeton University
Pamela J. Hornby
Pamela J. Hornby Johnson & Johnson (United States)
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Alexander Tulinsky
Alexander Tulinsky Michigan State University
Emilio Perucca
Emilio Perucca University of Pavia
M. Reza Ghadiri
M. Reza Ghadiri Scripps Research Institute
K. C. Nicolaou
K. C. Nicolaou Rice University
Laurence A. Nafie
Laurence A. Nafie Syracuse University
Dennis C. Liotta
Dennis C. Liotta Emory University
Eric J. Simon
Eric J. Simon New York University

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