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Richard C. Austin

Richard C. Austin

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
12684
World Ranking
13757
National Ranking
476

Overview

Richard C. Austin is a researcher affiliated with McMaster University in Canada with an extensive publication record spanning fields such as Medicine and Biochemistry, Genetics and Molecular Biology. Their scholarly contributions focus on diverse subfields including Surgery, Cell Biology, Epidemiology, Molecular Biology, and Immunology.

Austin's work encompasses key topics related to cellular stress responses, lipid metabolism, and cardiovascular health. Notable thematic areas include Endoplasmic Reticulum Stress and Disease, Lipoproteins and Cardiovascular Health, Cholesterol and Lipid Metabolism, Autophagy in Disease and Therapy, Atherosclerosis and Cardiovascular Diseases, Liver Disease Diagnosis and Treatment, and Pancreatic function and diabetes.

The researcher has contributed to several recent papers, illustrating a range of interests and collaborative efforts within biomedical research. These include:

  • Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, 2020, European Respiratory Journal
  • Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance, 2022, Nature Communications
  • Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles, 2020, Cell Reports
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders, 2021, IUBMB Life
  • Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells, 2021, Journal of Biological Chemistry

Richard C. Austin frequently collaborates with established researchers such as Jae Hyun Byun, Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, and Roger Colbran, demonstrating a network of recurring coauthorships with multiple publications alongside each partner.

Their contributions are predominantly published in venues including:

  • Journal of Biological Chemistry
  • Metabolism
  • Molecular Genetics and Metabolism
  • Atherosclerosis
  • European Respiratory Journal

Austin's multidisciplinary research applies molecular biology approaches to clinical and biomedical questions, particularly regarding cellular stress mechanisms and cardiovascular metabolic processes. The steady focus on endoplasmic reticulum stress highlights the intersection between molecular pathways and disease etiology.

Best Publications

  • Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

    Geoff H. Werstuck;Steven R. Lentz;Sanjana Dayal;Gazi S. Hossain

  • Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.

    Ramachandra K. Reddy;Changhui Mao;Peter Baumeister;Richard C. Austin

  • Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease

    R C Austin;S R Lentz;G H Werstuck

  • Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells

    P. A. Outinen;S. K. Sood;S. I. Pfeifer;S. Pamidi

  • Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis

    Sarathi Mani;Hongzhu Li;Ashley Untereiner;Lingyun Wu

  • Blood volume, cardiac output, and distribution of systemic blood flow in extreme obesity.

    Alexander Jk;Dennis Ew;Smith Wg;Amad Kh

  • Activation of the Unfolded Protein Response Occurs at All Stages of Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice

    Ji Zhou;Šárka Lhoták;Brooke A. Hilditch;Richard C. Austin

  • Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

    Pei-Xiang Li;Pei-Xiang Li;Jeffrey Wong;Jeffrey Wong;Ayeda Ayed;Duc Ngo;Duc Ngo

  • Hyperhomocysteinemia and its role in the development of atherosclerosis.

    A.B. Lawrence de Koning;Geoff H. Werstuck;Ji Zhou;Richard C. Austin

  • Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3

    Anna J. Kim;Yuanyuan Shi;Richard C. Austin;Geoff H. Werstuck

  • Characterization of the stress-inducing effects of homocysteine.

    P. A. Outinen;S. K. Sood;P. C. Y. Liaw;K. D. Sarge

  • TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia

    Gazi S. Hossain;Johannes V. van Thienen;Geoff H. Werstuck;Ji Zhou

  • Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease: Endoplasmic Reticulum Stress As a Mediator of Pathogenesis

    Jeffrey G. Dickhout;Rachel E. Carlisle;Richard C. Austin

  • The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

    Sana Basseri;Šárka Lhoták;Arya M. Sharma;Richard C. Austin

  • Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential

    Sana Basseri;Richard C. Austin

  • Peroxynitrite Causes Endoplasmic Reticulum Stress and Apoptosis in Human Vascular Endothelium Implications in Atherogenesis

    Jeffrey G. Dickhout;Gazi S. Hossain;Lindsay M. Pozza;Ji Zhou

  • Dietary Supplementation With Methionine and Homocysteine Promotes Early Atherosclerosis but Not Plaque Rupture in ApoE-Deficient Mice

    Ji Zhou;Jan Møller;Carl C. Danielsen;Jacob Bentzon

  • Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice

    Ji Zhou;Geoff H. Werstuck;Šárka Lhoták;A. B. Lawrence de Koning

  • Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2.

    Stephen M. Colgan;Damu Tang;Geoff H. Werstuck;Richard C. Austin

  • Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms.

    Ji Zhou;Richard C. Austin;Richard C. Austin

Frequent Co-Authors

Morris A. Blajchman
Morris A. Blajchman McMaster University
Nabil G. Seidah
Nabil G. Seidah University of Montreal
Gregory R. Steinberg
Gregory R. Steinberg McMaster University
Jeffrey I. Weitz
Jeffrey I. Weitz McMaster University
Donald W. Jacobsen
Donald W. Jacobsen Cleveland Clinic Lerner College of Medicine
Damu Tang
Damu Tang McMaster University
Richard A. Rachubinski
Richard A. Rachubinski University of Alberta
Salvatore V. Pizzo
Salvatore V. Pizzo Duke University
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Peter N. Ray
Peter N. Ray University of Toronto

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