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Overview

Hieronim Jakubowski is affiliated with Rutgers, The State University of New Jersey in the United States. Their research career spans multiple disciplines, primarily focusing on medicine and biochemistry, genetics, and molecular biology. Within these broad fields, Jakubowski's work is especially associated with rheumatology, clinical biochemistry, molecular biology, biochemistry, and physiology.

The main topics covered in Jakubowski's research include folate and B vitamins, paraoxonase enzyme and its polymorphisms, epigenetics and DNA methylation, biochemical acid research, apelin-related biomedical research, metabolism and genetic disorders, and Alzheimer's disease research and treatments.

Jakubowski has published extensively in various scientific journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Journal of Alzheimer's Disease
  • Preprints.org
  • Scientific Reports

Several recent papers authored or coauthored by Jakubowski highlight specific aspects of their research. Notable publications are:

  • The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study (2020, Journal of Clinical Medicine)
  • Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment (2021, Journal of Alzheimer's Disease)
  • Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease (2025, International Journal of Molecular Sciences)
  • COVID-19 and One-Carbon Metabolism (2022, International Journal of Molecular Sciences)
  • Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic (2020, Expert Review of Proteomics)

Jakubowski's collaborative network includes frequent coauthors such as Łukasz Witucki, Joanna Perła-Kaján, Marta Sikora, Ewa Bretes, and Olga Utyro. These collaborations reflect ongoing and sustained partnerships across multiple research projects.

Best Publications

  • Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.

    Hieronim Jakubowski

  • Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels

    Hieronim Jakubowski

  • Editing of errors in selection of amino acids for protein synthesis.

    Hieronim Jakubowski;Emanuel Goldman

  • Homocysteine Thiolactone and Protein Homocysteinylation in Human Endothelial Cells: Implications for Atherosclerosis

    Hieronim Jakubowski;Li Zhang;Arlene Bardeguez;Abram Aviv

  • Metabolism of Homocysteine Thiolactone in Human Cell Cultures POSSIBLE MECHANISM FOR PATHOLOGICAL CONSEQUENCES OF ELEVATED HOMOCYSTEINE LEVELS

    Hieronim Jakubowski

  • Mechanisms of homocysteine toxicity in humans

    J. Perła-Kaján;T. Twardowski;Hieronim Jakubowski;Hieronim Jakubowski

  • Molecular basis of homocysteine toxicity in humans.

    Hieronim Jakubowski

  • Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans

    Hieronim Jakubowski

  • Pathophysiological Consequences of Homocysteine Excess

    Hieronim Jakubowski

  • Homocysteine Modification in Protein Structure/Function and Human Disease.

    Hieronim Jakubowski

  • Alternative pathways for editing non-cognate amino acids by aminoacyl-tRNA synthetases

    Hieronim Jakubowski;Alan R.Fersht

  • Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.

    Hieronim Jakubowski

  • The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.

    Hieronim Jakubowski

  • Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis.

    Anetta Undas;Joanna Perła;Joanna Perła;Mariusz Łacinski;Wiesław Trzeciak

  • Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells

    Hieronim Jakubowski;Emanuel Goldman

  • Plasma Homocysteine Affects Fibrin Clot Permeability and Resistance to Lysis in Human Subjects

    Anetta Undas;Jan Brożek;Miłosz Jankowski;Zbigniew Siudak

  • Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation

    Rafał Głowacki;Hieronim Jakubowski;Hieronim Jakubowski

  • Genetic determinants of homocysteine thiolactonase activity in humans: Implications for atherosclerosis

    Hieronim Jakubowski;Walter T Ambrosius;J.Howard Pratt;J.Howard Pratt

  • The determination of homocysteine-thiolactone in human plasma

    Grazyna Chwatko;Hieronim Jakubowski;Hieronim Jakubowski

  • Mutations in methylenetetrahydrofolate reductase or cystathionine β-syntase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice

    Grazyna Chwatko;Godfried H. J. Boers;Kevin A. Strauss;Diana M. Shih

Frequent Co-Authors

Barry S. Cooperman
Barry S. Cooperman University of Pennsylvania
Grethe S. Tell
Grethe S. Tell University of Bergen
Andrew I. Schafer
Andrew I. Schafer Cornell University
Andrzej Szczeklik
Andrzej Szczeklik Jagiellonian University
Thomas Haertlé
Thomas Haertlé INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
William Durante
William Durante University of Missouri
Jean-Marc Chobert
Jean-Marc Chobert INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
Alan D. Irvine
Alan D. Irvine Trinity College Dublin
Helga Refsum
Helga Refsum University of Oslo
Aldons J. Lusis
Aldons J. Lusis University of California, Los Angeles

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