His scientific interests lie mostly in Homocysteine, Biochemistry, Internal medicine, Methionine and Endocrinology. His Homocysteine research is multidisciplinary, relying on both Amino acid, Thioester and High-performance liquid chromatography, Chromatography, Ultrafiltration. Hieronim Jakubowski interconnects Aminoacyl tRNA synthetase, Transfer RNA, Amino Acyl-tRNA Synthetases and Toxicity in the investigation of issues within Amino acid.
He has researched Chromatography in several fields, including Metabolite and Escherichia coli. His Biochemistry research focuses on subjects like Thiolactone, which are linked to Biosynthesis. His Endocrinology study combines topics in areas such as Cystathionine beta synthase and Methylenetetrahydrofolate reductase.
The scientist’s investigation covers issues in Biochemistry, Homocysteine, Internal medicine, Endocrinology and Methionine. His research related to Amino acid, Transfer RNA, Enzyme, Aminoacyl tRNA synthetase and Lysine might be considered part of Biochemistry. His Homocysteine research includes elements of Thioester, Cystathionine beta synthase, Chromatography and Paraoxonase.
While the research belongs to areas of Internal medicine, he spends his time largely on the problem of PON1, intersecting his research to questions surrounding Lipoprotein and Cholesterol. His Endocrinology research is multidisciplinary, incorporating perspectives in Thiol, Vascular disease and Methylenetetrahydrofolate reductase. His Methionine research is multidisciplinary, incorporating elements of Epitope, Antigen, Methyltransferase and Metabolism.
Hieronim Jakubowski mainly focuses on Homocysteine, Internal medicine, Endocrinology, Biochemistry and Hyperhomocysteinemia. The concepts of his Homocysteine study are interwoven with issues in Vitamin B12, Toxicity, Genotype and Cystathionine beta synthase, Methionine. His Methionine study integrates concerns from other disciplines, such as Metabolism and Bacteria.
In his research on the topic of Internal medicine, Paraoxonase is strongly related with PON1. His research in Hyperhomocysteinemia intersects with topics in Metabolite, Molecular biology, Gene expression and Neurotoxicity. His work is dedicated to discovering how Amino acid, TRNA aminoacylation are connected with Genetic code and other disciplines.
His primary areas of investigation include Homocysteine, Internal medicine, Endocrinology, Hyperhomocysteinemia and Biochemistry. The study incorporates disciplines such as Genetic disorder, Human disease, Connective tissue, Protein structure function and Metabolism in addition to Homocysteine. As a part of the same scientific study, he usually deals with the Internal medicine, concentrating on Gastroenterology and frequently concerns with Plasminogen activator inhibitor-1, Cholesterol, Arterial stiffness and Obesity.
His studies in Endocrinology integrate themes in fields like Composition, Betaine and Trimethylglycine. Hieronim Jakubowski combines subjects such as Metabolite, Neurotoxicity, Gene expression and Neurodegeneration with his study of Hyperhomocysteinemia. Biochemistry and Chromatography are frequently intertwined in his study.
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Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.
Hieronim Jakubowski.
Journal of Biological Chemistry (2000)
Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels
Hieronim Jakubowski.
The FASEB Journal (1999)
Editing of errors in selection of amino acids for protein synthesis.
Hieronim Jakubowski;Emanuel Goldman.
Microbiological Research (1992)
Homocysteine Thiolactone and Protein Homocysteinylation in Human Endothelial Cells: Implications for Atherosclerosis
Hieronim Jakubowski;Li Zhang;Arlene Bardeguez;Abram Aviv.
Circulation Research (2000)
Metabolism of Homocysteine Thiolactone in Human Cell Cultures POSSIBLE MECHANISM FOR PATHOLOGICAL CONSEQUENCES OF ELEVATED HOMOCYSTEINE LEVELS
Hieronim Jakubowski.
Journal of Biological Chemistry (1997)
Molecular basis of homocysteine toxicity in humans.
Hieronim Jakubowski.
Cellular and Molecular Life Sciences (2004)
Mechanisms of homocysteine toxicity in humans
J. Perła-Kaján;T. Twardowski;Hieronim Jakubowski;Hieronim Jakubowski.
Amino Acids (2007)
Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans
Hieronim Jakubowski.
Journal of Nutrition (2000)
Pathophysiological Consequences of Homocysteine Excess
Hieronim Jakubowski.
Journal of Nutrition (2006)
Alternative pathways for editing non-cognate amino acids by aminoacyl-tRNA synthetases
Hieronim Jakubowski;Alan R.Fersht.
Nucleic Acids Research (1981)
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