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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
124
Citations
53087
World Ranking
461
National Ranking
268

Biology and Biochemistry

D-Index
127
Citations
54623
World Ranking
476
National Ranking
305

Medicine

D-Index
125
Citations
54098
World Ranking
3114
National Ranking
1720

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2017 - Fellow of Alfred P. Sloan Foundation
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Amy S. Lee is affiliated with the University of Southern California in the United States. Their research mainly focuses on medicine and biochemistry, genetics, and molecular biology, with significant contributions across several subfields including cell biology, infectious diseases, molecular biology, epidemiology, and genetics.

Their work explores several important topics such as endoplasmic reticulum stress and disease, SARS-CoV-2 and COVID-19 research, autophagy in disease and therapy, vaccine coverage and hesitancy, heat shock proteins research, viral gastroenteritis research and epidemiology, and cellular transport and secretion.

Frequent publication venues for Amy S. Lee include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Journal of Biological Chemistry
  • Journal of Medical Economics
  • Neoplasia

Notable recent papers authored include:

  • The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection, 2021, Journal of Biological Chemistry
  • The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer, 2021, Cancer Research
  • ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator, 2023, Proceedings of the National Academy of Sciences
  • The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection, 2020, Journal of Infection
  • The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein, 2022, Nature Communications

Frequent co-authors collaborating with Amy S. Lee include:

  • Dat P. Ha
  • Michele Kohli
  • Michael Maschio
  • Nicolas Van de Velde
  • Bonnie Cole

Amy S. Lee has been recognized as a fellow by prominent organizations including the Alfred P. Sloan Foundation in 2017 and the American Association for the Advancement of Science (AAAS) in 2006.

Best Publications

  • The glucose-regulated proteins: stress induction and clinical applications.

    Amy S Lee

  • The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.

    Amy S. Lee

  • GRP78 Induction in Cancer: Therapeutic and Prognostic Implications

    Amy S. Lee

  • ER chaperones in mammalian development and human diseases

    Min Ni;Amy S. Lee

  • Peroxisomes are signaling platforms for antiviral innate immunity

    Evelyn Dixit;Steeve Boulant;Yijing Zhang;Amy S.Y. Lee

  • Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.

    Ramachandra K. Reddy;Changhui Mao;Peter Baumeister;Richard C. Austin

  • Stress Induction of GRP78/BiP and Its Role in Cancer

    Jianze Li;Amy S Lee

  • Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

    Amy S. Lee

  • Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.

    Jianze Li;Brenda Lee;Amy S. Lee

  • The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

    Biquan Luo;Amy S. Lee

  • Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

    Min Ni;Yi Zhang;Amy S. Lee

  • Mammalian stress response: induction of the glucose-regulated protein family

    Amy S Lee

  • Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

    Miao Wang;Shiuan Wey;Yi Zhang;Risheng Ye

  • Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells

    Amy S. Lee

  • Ca2+/calmodulin binds to and modulates P/Q-type calcium channels.

    Amy Lee;Scott T. Wong;Daniel Gallagher;Bin Li

  • The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas

    Peter Pyrko;Axel H. Schönthal;Florence M. Hofman;Thomas C. Chen

  • GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.

    Shengzhan Luo;Changhui Mao;Brenda Lee;Amy S. Lee

  • The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

    Edward Little;Meera Ramakrishnan;Binayak Roy;Gadi Gazit

  • The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

    J Li;M Ni;M Ni;B Lee;E Barron

  • Endoplasmic reticulum stress.

    Gábor Bánhegyi;Peter Baumeister;Angelo Benedetti;Dezheng Dong

Frequent Co-Authors

Robert E. W. Hancock
Robert E. W. Hancock University of British Columbia
Joseph D. Tucker
Joseph D. Tucker University of North Carolina at Chapel Hill
Richard G. Ellenbogen
Richard G. Ellenbogen University of Washington
David S. Guttman
David S. Guttman University of Toronto
Evette J. Ludman
Evette J. Ludman Kaiser Permanente
John J. Mekalanos
John J. Mekalanos Harvard Medical School
Darrell Desveaux
Darrell Desveaux University of Toronto
Jeffrey G. Ojemann
Jeffrey G. Ojemann University of Washington
Susan Groshen
Susan Groshen University of Southern California
Emily C. Williams
Emily C. Williams University of Washington

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