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Biology and Biochemistry

D-Index
85
Citations
20803
World Ranking
3209
National Ranking
1624

Overview

Thomas E. Eling is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on subfields including Rheumatology, Immunology, Cellular and Molecular Neuroscience, Physiology, and Molecular Biology.

Their work addresses a range of key topics such as GDF15 and related biomarkers, macrophage migration inhibitory factor, nuclear receptors and signaling, nutrition and health in aging, circular RNAs in diseases, protein hydrolysis and bioactive peptides, and inflammatory mediators and NSAID effects.

Thomas E. Eling has publications in various scientific journals, including:

  • Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation, 2022, Redox Biology
  • NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells, 2022, Life Sciences
  • The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice, 2021, Scientific Reports
  • NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets, 2022, Molecular and Cellular Endocrinology
  • NAG-1/GDF15 as a tumor suppressor in colorectal cancer: inhibition of β-catenin and NF-κB pathways via interaction with EpCAM, 2025, Cell Death and Disease

This research has been published across several venues, with repeated publications in UNC Libraries, and individual contributions in Redox Biology, Life Sciences, Scientific Reports, and Molecular and Cellular Endocrinology.

The list of frequent co-authors includes:

  • Seung Joon Baek
  • Chaojie Chen
  • Jiajun Chen
  • Tingting Sang
  • Peng He

Best Publications

  • The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates.

    P D Josephy;T Eling;R P Mason

  • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.

    Toshihiko Tanno;Natarajan V Bhanu;Patricia A Oneal;Sung-Ho Goh

  • Prostaglandin H synthase and xenobiotic oxidation.

    T E Eling;D C Thompson;G L Foureman;J F Curtis

  • Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia.

    Tongguang Wang;Liya Qin;Bin Liu;Yuxin Liu

  • Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES

    Hironori Matsuura;Morito Sakaue;Kotha Subbaramaiah;Hideki Kamitani

  • Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ A NOVEL MECHANISM FOR ITS ANTI-TUMORIGENIC ACTIVITY

    Seung Joon Baek;Leigh C. Wilson;Linda C. Hsi;Thomas E. Eling

  • NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

    Kali Chrysovergis;Xingya Wang;Justin Kosak;Seong-Ho Lee

  • Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53

    Seung Joon Baek;Leigh C. Wilson;Thomas E. Eling

  • Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein

    Seung Joon Baek;Jong-Sik Kim;Scott M Moore;Seong-Ho Lee

  • Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 Over Expression in Transgenic Mice Suppresses Intestinal Neoplasia

    Seung Joon Baek;Ryuji Okazaki;Seong-Ho Lee;Jeanelle Martinez

  • Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation

    Michael R. Gunther;Linda C. Hsi;John F. Curtis;James K. Gierse

  • Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells.

    Seung Joon Baek;Jong-Sik Kim;Felix R. Jackson;Thomas E. Eling

  • Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter BASAL TRANSCRIPTION IS MEDIATED BY Sp1 AND Sp3

    Seung Joon Baek;Jonathan M. Horowitz;Thomas E. Eling

  • Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene EGR-1

    Seung Joon Baek;Seung Joon Baek;Jong-Sik Kim;Jennifer B. Nixon;Richard P. DiAugustine

  • Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis

    Uddhav P. Kelavkar;Jennifer B. Nixon;Cynthia Cohen;Dirk Dillehay

  • Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene.

    Seung Joon Baek;Leigh C. Wilson;Chang-Ho Lee;Thomas E. Eling

  • The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer.

    Xingya Wang;Seung Joon Baek;Thomas E. Eling

  • Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.

    Seong-Ho Lee;Jong-Sik Kim;Kiyoshi Yamaguchi;Thomas E. Eling

  • Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.

    W.C. Glasgow;C.A. Afshari;J.C. Barrett;T.E. Eling

  • Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner

    Seong-Ho Lee;Kiyoshi Yamaguchi;Jong-Sik Kim;Thomas E. Eling

Frequent Co-Authors

Seung Joon Baek
Seung Joon Baek Seoul National University
Ronald P. Mason
Ronald P. Mason National Institutes of Health
Paul Nettesheim
Paul Nettesheim National Institutes of Health
Jeff Boyd
Jeff Boyd Fox Chase Cancer Center
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
Errol Zeiger
Errol Zeiger National Institutes of Health
Robert Langenbach
Robert Langenbach National Institutes of Health
Kenneth B. Tomer
Kenneth B. Tomer National Institutes of Health
Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Jack Odle
Jack Odle North Carolina State University

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