Julian F.B. Mercer spends much of his time researching Menkes disease, Biochemistry, ATP7A, Copper-transporting ATPases and Copper deficiency. His Menkes disease research incorporates elements of P-type ATPase, ATPase, Phenotype, Neurodegeneration and Efflux. His ATP7A research is multidisciplinary, relying on both Transport protein and Cell biology.
His Copper-transporting ATPases research integrates issues from ATP7A Gene and Secretory pathway. His work carried out in the field of Copper deficiency brings together such families of science as Genetics, Occipital horn syndrome, Homeostasis and Menkes Kinky Hair Syndrome. His Bioinformatics study incorporates themes from Internal medicine, Disease, Endocrinology and Amyloid precursor protein.
His primary scientific interests are in Biochemistry, ATP7A, Menkes disease, Cell biology and ATPase. Biochemistry is represented through his Copper-transporting ATPases, P-type ATPase, Wilson disease protein, Copper homeostasis and P-type ATPases research. His research on ATP7A also deals with topics like
His Menkes disease research is multidisciplinary, incorporating perspectives in Molecular biology, Copper deficiency, Internal medicine and Endocrinology. His research in Cell biology intersects with topics in Cell, Exocytosis and Central nervous system. The various areas that Julian F.B. Mercer examines in his ATPase study include Cell culture, Chaperone and Yeast.
His primary areas of investigation include Biochemistry, ATP7A, Cell biology, Menkes disease and Copper deficiency. His work in ATP7A addresses issues such as P-type ATPase, which are connected to fields such as Oxidoreductase and Cysteine. His study in Cell biology is interdisciplinary in nature, drawing from both Neurotoxicity, Central nervous system and Dorsal root ganglion.
Particularly relevant to Occipital horn syndrome is his body of work in Menkes disease. His work deals with themes such as Menkes Kinky Hair Syndrome, Reactive oxygen species, Neurodegeneration and Neuroscience, which intersect with Copper deficiency. His Copper-transporting ATPases research incorporates themes from Wilson disease protein and Protein degradation.
Julian F.B. Mercer mainly focuses on Menkes disease, Biochemistry, Copper deficiency, ATP7A and Human brain. His studies deal with areas such as Genetics and Missense mutation as well as Menkes disease. The study incorporates disciplines such as Neuroglia and Astrocyte in addition to Biochemistry.
His Copper deficiency study combines topics from a wide range of disciplines, such as Neurodegeneration, Occipital horn syndrome, X chromosome, Genetic heterogeneity and Neuroscience. His research in ATP7A is mostly concerned with Copper-transporting ATPases. Julian F.B. Mercer interconnects Parkinson's disease and Alpha-synuclein in the investigation of issues within Human brain.
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Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases.
Daniel Strausak;Julian F.B Mercer;Hermann H Dieter;Wolfgang Stremmel.
Brain Research Bulletin (2001)
The molecular basis of copper-transport diseases.
Julian F.B Mercer.
Trends in Molecular Medicine (2001)
Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis
Sharon La Fontaine;Julian F.B. Mercer.
Archives of Biochemistry and Biophysics (2007)
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
Anthony R White;Rosario Reyes;Rosario Reyes;Julian F.B Mercer;Julian F.B Mercer;James Camakaris.
Brain Research (1999)
Molecular mechanisms of copper homeostasis.
J. Camakaris;I. Voskoboinik;J.F. Mercer.
Biochemical and Biophysical Research Communications (1999)
Metabolism and functions of copper in brain.
Ivo F. Scheiber;Julian F.B. Mercer;Ralf Dringen.
Progress in Neurobiology (2014)
The Menkes Copper Transporter Is Required for the Activation of Tyrosinase
Michael J. Petris;Daniel Strausak;Julian F.B. Mercer.
Human Molecular Genetics (2000)
Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux
James Camakaris;Michael J. Petris;Leanne Bailey;Peiyan Shen.
Human Molecular Genetics (1995)
The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal.
Michael J. Petris;Julian F.B. Mercer.
Human Molecular Genetics (1999)
The Role of GMXCXXC Metal Binding Sites in the Copper-induced Redistribution of the Menkes Protein
Daniel Strausak;Sharon La Fontaine;Joanne Hill;Stephen D. Firth.
Journal of Biological Chemistry (1999)
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