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Clifford A. Lingwood

Clifford A. Lingwood

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12083
World Ranking
7590
National Ranking
262

Overview

Clifford A. Lingwood is affiliated with the University of Toronto in Canada and has made contributions primarily in the fields of biochemistry, genetics, and molecular biology. Their research spans an array of subfields, including molecular biology, endocrinology, cell biology, genetics, and infectious diseases.

The scientist's main research topics include:

  • Escherichia coli research studies
  • Glycosylation and Glycoproteins Research
  • Endoplasmic Reticulum Stress and Disease
  • Bacterial Genetics and Biotechnology
  • Clostridium difficile and Clostridium perfringens research
  • Sphingolipid Metabolism and Signaling
  • Cellular transport and secretion

Lingwood's recent publications reflect a focus on cellular and molecular mechanisms related to bacterial toxins, lipid metabolism, and neurological disorders. Notable papers include:

  • "Verotoxin Receptor-Based Pathology and Therapies," 2020, Frontiers in Cellular and Infection Microbiology
  • "Therapeutic Uses of Bacterial Subunit Toxins," 2021, Toxins
  • "ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species," 2021, Journal of Lipid Research
  • "Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?," 2024, Lipids in Health and Disease

Frequent collaborators include Monique Budani and Christiane Auray-Blais, indicating interdisciplinary work that likely integrates molecular biology and biochemical approaches.

Lingwood has published in various scientific journals, with multiple works featured in:

  • Frontiers in Cellular and Infection Microbiology
  • Toxins
  • Journal of Lipid Research
  • Lipids in Health and Disease

Best Publications

  • Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro.

    C. A. Lingwood;H. Law;S. Richardson;M. Petric

  • Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane

    Mathias J. Gerl;Julio L. Sampaio;Severino Urban;Lucie Kalvodova

  • Globotetraosylceramide Is Recognized by the Pig Edema Disease Toxin

    S DeGrandis;H Law;J Brunton;C Gyles

  • Cholesterol modulates glycolipid conformation and receptor activity

    Daniel Lingwood;Beth Binnington;Tomasz Róg;Ilpo Vattulainen;Ilpo Vattulainen;Ilpo Vattulainen

  • Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.

    M Huesca;S Borgia;P Hoffman;C A Lingwood

  • The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine.

    C A Lingwood;M Huesca;A Kuksis

  • Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic.

    Sara Arab;Clifford A. Lingwood

  • Differential tissue targeting and pathogenesis of verotoxins 1 and 2 in the mouse animal model

    Niels W.P. Rutjes;Beth A. Binnington;Charles R. Smith;Mark D. Maloney

  • Comparison of Helicobacter pylori and attaching-effacing Escherichia coli adhesion to eukaryotic cells.

    M Dytoc;B Gold;M Louie;M Huesca

  • Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis.

    Prateek Lala;Shinya Ito;Clifford A. Lingwood

  • Globotriaosyl ceramide receptor function – Where membrane structure and pathology intersect

    C.A. Lingwood;B. Binnington;A. Manis;D.R. Branch;D.R. Branch

  • CD19 has a potential CD77 (globotriaosyl ceramide)-binding site with sequence similarity to verotoxin B-subunits: implications of molecular mimicry for B cell adhesion and enterohemorrhagic Escherichia coli pathogenesis.

    Mark D. Maloney;Clifford A. Lingwood

  • Role of Multiple Drug Resistance Protein 1 in Neutral but Not Acidic Glycosphingolipid Biosynthesis

    Maria Fabiana De Rosa;Daniel Sillence;Cameron Ackerley;Clifford A. Lingwood

  • Capping and receptor‐mediated endocytosis of cell‐bound verotoxin (shiga‐like toxin) 1: Chemical identification of an amino acid in the B subunit necessary for efficient receptor glycolipid binding and cellular internalization

    A. A. Khine;C. A. Lingwood

  • Expression of glycolipid receptors to Shiga-like toxin on human B lymphocytes: a mechanism for the failure of long-lived antibody response to dysenteric disease.

    Amos Cohen;Vicente Madrid-marina;Zeev Estrov;Melvin H. Freedman

  • Glycolipid receptors for verotoxin and Helicobacter pylori: role in pathology

    Clifford A Lingwood

  • Two distinct binding sites for globotriaosyl ceramide on verotoxins: identification by molecular modelling and confirmation using deoxy analogues and a new glycolipid receptor for all verotoxins

    Per-Georg Nyholm;Go¨ran Magnusson;Zhiyuan Zheng;Raquel Norel

  • Alteration of the glycolipid binding specificity of the pig edema toxin from globotetraosyl to globotriaosyl ceramide alters in vivo tissue targetting and results in a verotoxin 1-like disease in pigs.

    B Boyd;G Tyrrell;M Maloney;C Gyles

  • Lipid modulation of glycolipid receptor function

    Beth Boyd;Göran Magnusson;Zhang Zhiuyan;Clifford A. Lingwood

  • Helicobacter mustelae and Helicobacter pylori bind to common lipid receptors in vitro.

    B D Gold;M Huesca;P M Sherman;C A Lingwood

Frequent Co-Authors

Philip M. Sherman
Philip M. Sherman University of Toronto
Jeffrey A. Medin
Jeffrey A. Medin Medical College of Wisconsin
Martin L. Olsson
Martin L. Olsson Lund University
Paul S. Hoffman
Paul S. Hoffman University of Virginia
Dana J. Philpott
Dana J. Philpott University of Toronto
Mohamed A. Karmali
Mohamed A. Karmali Public Health Agency of Canada
Jacques Fantini
Jacques Fantini Aix-Marseille University
Jeffrey L. Brodsky
Jeffrey L. Brodsky University of Pittsburgh
James T. Rutka
James T. Rutka University of Toronto
Cameron Ackerley
Cameron Ackerley University of Toronto

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