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Biology and Biochemistry

D-Index
70
Citations
14747
World Ranking
7136
National Ranking
233

Overview

Jacques Fantini is affiliated with Aix-Marseille University in France and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research focuses significantly on Infectious Diseases and Molecular Biology, with additional work in Cellular and Molecular Neuroscience, Neurology, and Ecology.

Their research topics emphasize SARS-CoV-2 and COVID-19, particularly in understanding viral mechanisms and clinical studies related to the pandemic. The main areas of investigation include:

  • SARS-CoV-2 and COVID-19 Research
  • Lipid Membrane Structure and Behavior
  • COVID-19 Clinical Research Studies
  • Bacteriophages and microbial interactions
  • Viral gastroenteritis research and epidemiology
  • Glycosylation and Glycoproteins Research
  • Vaccines and immunoinformatics approaches

Fantini's recent publications reflect a strong focus on viral infections and molecular dynamics. Notable papers include:

  • Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection, 2020, International Journal of Antimicrobial Agents
  • Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal, 2020, International Journal of Antimicrobial Agents
  • The puzzling mutational landscape of the SARS-2-variant Omicron, 2022, Journal of Medical Virology
  • Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks, 2021, Journal of Infection
  • Culture and identification of a "Deltamicron" SARS-CoV-2 in a three cases cluster in southern France, 2022, Journal of Medical Virology

Their collaborations include frequent coauthors such as Nouara Yahi, Henri Chahinian, Philippe Colson, Fodil Azzaz, and Bernard La Scola. These partnerships contribute to a multidisciplinary approach combining virology, molecular biology, and clinical perspectives.

Fantini has published primarily in several scientific journals, with a concentration in:

  • Journal of Medical Virology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Viruses
  • Journal of Infection

Best Publications

  • Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection.

    Jacques Fantini;Jacques Fantini;Coralie Di Scala;Henri Chahinian;Nouara Yahi

  • How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

    Jacques Fantini;Francisco José Barrantes

  • CH–π hydrogen bonds in biological macromolecules

    Motohiro Nishio;Yoji Umezawa;Jacques Fantini;Manfred S. Weiss

  • Infection of colonic epithelial cell lines by type 1 human immunodeficiency virus is associated with cell surface expression of galactosylceramide, a potential alternative gp120 receptor.

    Jacques Fantini;David G. Cook;Neal Nathanson;Steven L. Spitalnik

  • Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases.

    Jacques Fantini;Nicolas Garmy;Radhia Mahfoud;Nouara Yahi

  • Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells.

    N Yahi;S Baghdiguian;H Moreau;J Fantini

  • The Mycotoxin Patulin Alters the Barrier Function of the Intestinal Epithelium: Mechanism of Action of the Toxin and Protective Effects of Glutathione

    Radhia Mahfoud;Marc Maresca;Nicolas Garmy;Jacques Fantini

  • The Mycotoxin Deoxynivalenol Affects Nutrient Absorption in Human Intestinal Epithelial Cells

    Marc Maresca;Radhia Mahfoud;Nicolas Garmy;Jacques Fantini

  • Identification of a Common Sphingolipid-binding Domain in Alzheimer, Prion, and HIV-1 Proteins

    Radhia Mahfoud;Nicolas Garmy;Marc Maresca;Nouara Yahi

  • Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

    Carlos J. Baier;Jacques Fantini;Francisco José Barrantes

  • Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function.

    Jacques Fantini;Francisco J. Barrantes

  • Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria

    Marc Maresca;Nouara Yahi;Lama Younès-Sakr;Marilyn Boyron

  • Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases.

    Marc Maresca;Jacques Fantini

  • Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases.

    Jacques Fantini;Nouara Yahi

  • Human Erythrocyte Glycosphingolipids as Alternative Cofactors for Human Immunodeficiency Virus Type 1 (HIV-1) Entry: Evidence for CD4-Induced Interactions between HIV-1 gp120 and Reconstituted Membrane Microdomains of Glycosphingolipids (Gb3 and GM3)

    Djilali Hammache;Nouara Yahi;Marc Maresca;Gérard Piéroni

  • Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

    Coralie Di Scala;Nouara Yahi;Sonia Boutemeur;Alessandra Flores

  • The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain

    Jacques Fantini;Denis Carlus;Nouara Yahi

  • Specific Interaction of HIV-1 and HIV-2 Surface Envelope Glycoproteins with Monolayers of Galactosylceramide and Ganglioside GM3

    Djilali Hammache;Gérard Piéroni;Nouara Yahi;Olivier Delézay

  • Molecular basis for the glycosphingolipid-binding specificity of α-synuclein: key role of tyrosine 39 in membrane insertion

    Jacques Fantini;Nouara Yahi

  • Synthetic Soluble Analogs of Galactosylceramide (GalCer) Bind to the V3 Domain of HIV-1 gp120 and Inhibit HIV-1-induced Fusion and Entry

    Jacques Fantini;Djilali Hammache;Olivier Delézay;Nouara Yahi

Frequent Co-Authors

Nouara Yahi
Nouara Yahi Aix-Marseille University
Catherine Tamalet
Catherine Tamalet Aix-Marseille University
Francisco J. Barrantes
Francisco J. Barrantes National Scientific and Technical Research Council
Patrick J. Cozzone
Patrick J. Cozzone Aix-Marseille University
Jean-Marc Sabatier
Jean-Marc Sabatier Aix-Marseille University
Francisco Gonzalez-Scarano
Francisco Gonzalez-Scarano University of Pennsylvania
Steven L. Spitalnik
Steven L. Spitalnik Columbia University
Dieter Willbold
Dieter Willbold Forschungszentrum Jülich
Bruce Ganem
Bruce Ganem Cornell University
Kuan-Teh Jeang
Kuan-Teh Jeang National Institutes of Health

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