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Microbiology

D-Index
91
Citations
27424
World Ranking
659
National Ranking
307

Overview

Alison D. O'Brien is affiliated with the Uniformed Services University of the Health Sciences in the United States. Their research spans multiple areas within medicine, particularly focusing on infectious diseases, clinical psychology, endocrinology, ecology, and health. The scientist has contributed to various fields through studies related to Escherichia coli, viral gastroenteritis, bacteriophages and microbial interactions, health disparities and outcomes, computational drug discovery methods, SARS-CoV-2 and COVID-19 research, as well as vaccines and immunoinformatics approaches.

Their recent published papers include:

  • The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool, 2020, Frontiers in Cellular and Infection Microbiology
  • Exploring Social Determinants of Health in Healthy Aging Among Older Adults: A Qualitative Study, 2023, Progress in Community Health Partnerships
  • A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • O017 Dupuytren's disease (DD): WNT4 knockdown in normal skin fibroblasts leads to 'DD-like' changes in the transcriptome, 2023, British Journal of Surgery
  • PROTOCOL: Bereavement Interventions for Children and Adolescents: An Evidence and Gap Map of Primary Studies and Systematic Reviews, 2025, Campbell Systematic Reviews

Frequent coauthors include:

  • Jocelyn R. Hauser
  • Rama R. Atitkar
  • Courtney D. Petro
  • Rebecca L. Lindsey
  • Nancy Strockbine

The most frequent publication venues for their work are:

  • Frontiers in Cellular and Infection Microbiology
  • Progress in Community Health Partnerships
  • bioRxiv (Cold Spring Harbor Laboratory)
  • British Journal of Surgery
  • Campbell Systematic Reviews

Best Publications

  • Shiga and Shiga-like toxins.

    Alison D. O'Brien;Randall K. Holmes

  • Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

    Flemming Scheutz;Louise D. Teel;Lothar Beutin;Denis Piérard

  • Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea

    AD O'Brien;JW Newland;SF Miller;RK Holmes

  • Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities.

    N A Strockbine;L R Marques;J W Newland;H W Smith

  • The Diarrheal Response of Humans to Some Classic Serotypes of Enteropathogenic Escherichia coli is Dependent on a Plasmid Encoding an Enteroadhesiveness Factor

    Myron M. Levine;James P. Nataro;Helge Karch;Mary M. Baldini

  • Production of Shigella dysenteriae Type 1-Like Cytotoxin by Escherichia coli

    Alison D. O'Brien;Gerald D. LaVeck;Michael R. Thompson;Samuel B. Formal

  • Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis.

    A. D. O'Brien;V. L. Tesh;A. Donohue-Rolfe;M. P. Jackson

  • Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages from Escherichia coli 933

    Matthew P. Jackson;Roger J. Neill;Alison D. O'Brien;Randall K. Holmes

  • Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

    Andrew T. Gewirtz;Peter O. Simon;Clare K. Schmitt;Laura J. Taylor

  • Genetic control of susceptibility to salmonella typhimurium in mice: role of the lps gene.

    A D O'Brien;D L Rosenstreich;I Scher;G H Campbell

  • The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model.

    M S Donnenberg;S Tzipori;M L McKee;A D O'Brien

  • Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice.

    V L Tesh;J A Burris;J W Owens;V M Gordon

  • Structure of shiga toxin type 2 (Stx2) from escherichia coli O157:H7

    Marie E. Fraser;Masao Fujinaga;Maia M. Cherney;Angela R. Melton-Celsa

  • Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1.

    Nancy A. Strockbine;Matthew Jackson;Lawrence Sung;Randall Holmes

  • Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine.

    D L Weinstein;M P Jackson;J E Samuel;R K Holmes

  • Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro.

    C R Lissner;R N Swanson;A D O'Brien

  • Two copies of Shiga-like toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157:H- strain E32511.

    Clare K. Schmitt;Marian L. McKee;Alison D. O'Brien

  • Escherichia coli O157:H7 Requires Intimin for Enteropathogenicity in Calves

    Evelyn A. Dean-Nystrom;Brad T. Bosworth;Harley W. Moon;Alison D. O’Brien

  • Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

    Clare K. Schmitt;Jack S. Ikeda;Stephen C. Darnell;Patricia R. Watson

  • Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli.

    Alison D. O'Brien;Gerald D. LaVeck

  • Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7.

    E A Wadolkowski;J A Burris;A D O'Brien

Frequent Co-Authors

Randall K. Holmes
Randall K. Holmes University of Colorado Denver
James E. Samuel
James E. Samuel Texas A&M University
Irwin Scher
Irwin Scher OperTechBio
James P. Nataro
James P. Nataro University of Virginia
James B. Kaper
James B. Kaper University of Maryland, Baltimore
Andrew B. Onderdonk
Andrew B. Onderdonk Brigham and Women's Hospital
Lynn W. Enquist
Lynn W. Enquist Princeton University
Eckard Wimmer
Eckard Wimmer Stony Brook University
C. Neal Stewart
C. Neal Stewart University of Tennessee at Knoxville

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