World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
122
Citations
68191
World Ranking
575
National Ranking
365

Research.com Recognitions

  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2002 - Member of the National Academy of Medicine (NAM)
  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1990 - Fellow of the Royal Society, United Kingdom
  • 1987 - Member of the National Academy of Sciences
  • 1970 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

George R. Stark is affiliated with the Cleveland Clinic in the United States. Their research spans several interconnected areas within medicine and molecular biology, focusing substantially on cancer and immunology. The body of work includes extensive investigation into cytokine signaling pathways, interferon and immune responses, and molecular mechanisms relevant to cancer development.

The scientist's main fields of study are Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to the subfields of Molecular Biology, Oncology, Immunology, Epidemiology, and Cancer Research. Their research covers these key topics:

  • Cytokine Signaling Pathways and Interactions
  • Interferon and immune responses
  • Immune Cell Function and Interaction
  • Nonmelanoma Skin Cancer Studies
  • Skin Protection and Aging
  • RNA regulation and disease
  • Cancer-related molecular mechanisms research

Recent publications by George R. Stark include:

  • The JAK-STAT pathway at 30: Much learned, much more to do, 2022, Cell
  • Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis, 2020, Nature Communications
  • How cancer cells make and respond to interferon-I, 2022, Trends in cancer
  • Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma, 2020, Nature Communications
  • Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells, 2021, Nature Cancer

The scientist has frequently published in venues such as the Proceedings of the National Academy of Sciences, Journal of Investigative Dermatology, Nature Communications, The EMBO Journal, and Cell.

Frequent collaborators in their work include:

  • Yuxin Wang
  • Elise Holvey-Bates
  • K. Mahen
  • Christine McDonald
  • HyeonJoo Cheon

George R. Stark's career has been recognized with multiple prestigious awards, including membership in the National Academy of Sciences since 1987 and the National Academy of Medicine since 2002. Other distinctions include Fellowship in the Royal Society of the United Kingdom, the American Academy of Arts and Sciences, the American Association for the Advancement of Science, and the John Simon Guggenheim Memorial Foundation.

Best Publications

  • How cells respond to interferons

    George R. Stark;Ian M. Kerr;Bryan R. G. Williams;Robert H. Silverman

  • Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

    Geoffrey M. Wahl;Michael Stern;George R. Stark

  • Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes

    James C. Alwine;David J. Kemp;George R. Stark

  • Regulation of the G2/M transition by p53.

    William R Taylor;George R Stark

  • The JAK-STAT pathway at twenty.

    George R. Stark;James E. Darnell

  • Interferons at age 50: past, current and future impact on biomedicine.

    Ernest C Borden;Ganes Sen;Gilles Uze;Robert H Silverman

  • p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

    Munna L. Agarwal;Archana Agarwal;William R. Taylor;George R. Stark

  • Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure

    Jaime Renart;Jakob Reiser;George R. Stark

  • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

    Ke Shuai;George R. Stark;Ian M. Kerr;James E. Darnell

  • Use of Dimethyl Suberimidate, a Cross-Linking Reagent, in Studying the Subunit Structure of Oligomeric Proteins

    Gregg E. Davies;George R. Stark

  • The p53 Network

    Munna L. Agarwal;William R. Taylor;Michail V. Chernov;Olga B. Chernova

  • Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

    Nywana Sizemore;Stewart Leung;George R. Stark

  • The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

    Mathias Müller;James Briscoe;Carl Laxton;Dmitry Guschin

  • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.

    David N Wald;Jinzhong Qin;Zhendong Zhao;Youcun Qian

  • Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

    Richard L. Friedman;Susan P. Manly;Martin McMahon;Ian M. Kerr

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

    Barbara A. Parker;George R. Stark

  • [15] Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper

    James C. Alwine;David J. Kemp;Barbara A. Parker;Jakob Reiser

  • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB

    Jinbo Yang;Xudong Liao;Mukesh K. Agarwal;Laura Barnes

  • IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

    Holger Wesche;Xiong Gao;Xiaoxia Li;Carsten J. Kirschning

Frequent Co-Authors

Ian M. Kerr
Ian M. Kerr The Honourable Society of Lincoln's Inn
Xiaoxia Li
Xiaoxia Li Cleveland Clinic Lerner College of Medicine
Geoffrey M. Wahl
Geoffrey M. Wahl Salk Institute for Biological Studies
Andrei V. Gudkov
Andrei V. Gudkov Roswell Park Cancer Institute
Robert H. Silverman
Robert H. Silverman Kent State University
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Mark R. Chance
Mark R. Chance Case Western Reserve University
Ganes C. Sen
Ganes C. Sen Case Western Reserve University
James Briscoe
James Briscoe The Francis Crick Institute
Belinda Willard
Belinda Willard Cleveland Clinic

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing George R. Stark

Trending Scientists

Recently Published Articles