World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
29681
World Ranking
2693
National Ranking
191

Research.com Recognitions

  • 2019 - Fellow of the Royal Society, United Kingdom

Overview

James Briscoe is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Molecular Biology, Cell Biology, Immunology, Developmental Neuroscience, and Public Health, Environmental and Occupational Health.

Their work encompasses several key topics, including:

  • Pluripotent Stem Cells Research
  • Developmental Biology and Gene Regulation
  • Single-cell and spatial transcriptomics
  • Congenital heart defects research
  • Gene Regulatory Network Analysis
  • Neurogenesis and neuroplasticity mechanisms
  • Zebrafish Biomedical Research Applications

James Briscoe has published extensively in scientific journals, with frequent publications in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Development
  • Developmental Cell
  • PLoS Biology
  • Science

Recent notable papers include:

  • "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" (2021, Nature Biotechnology)
  • "Species-specific pace of development is associated with differences in protein stability" (2020, Science)
  • "Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions" (2021, Cell Systems)
  • "Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features" (2021, Development)
  • "Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak" (2021, PLoS Biology)

Frequent co-authors collaborating with James Briscoe include:

  • Katherine Brown
  • M. Joaquina Delàs
  • Jake Cornwall-Scoones
  • Giulia L. M. Boezio
  • Manuela Melchionda

Among the recognitions received, James Briscoe was awarded the title of Fellow of the Royal Society, United Kingdom, in 2019.

Best Publications

  • The mechanisms of Hedgehog signalling and its roles in development and disease.

    James Briscoe;Pascal P. Thérond;Pascal P. Thérond

  • A homeodomain protein code specifying progenitor cell identity and neuronal fate in the ventral neural tube

    Thomas M. Jessell;James Briscoe;Johan Ericson;Johan Ericson

  • Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

    J Ericson;P Rashbass;A Schedl;S Brenner-Morton

  • The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

    Mathias Müller;James Briscoe;Carl Laxton;Dmitry Guschin

  • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

    J. Briscoe;L. Sussel;P. Serup;D. Hartigan-O'Connor

  • Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network.

    Eric Dessaud;Andrew P. McMahon;James Briscoe

  • Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

    Eric Dessaud;Lin Lin Yang;Lin Lin Yang;Katy Hill;Barny Cox

  • Specification of neuronal fates in the ventral neural tube.

    James Briscoe;Johan Ericson

  • The interpretation of morphogen gradients.

    Hilary L. Ashe;James Briscoe

  • A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

    D Guschin;N Rogers;J Briscoe;B Witthuhn

  • Neural crest development is regulated by the transcription factor Sox9.

    Martin Cheung;James Briscoe

  • Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.

    Nikolaos Balaskas;Ana Ribeiro;Jasmina Panovska;Eric Dessaud

  • The transcriptional control of trunk neural crest induction, survival, and delamination

    Martin Cheung;Marie Christine Chaboissier;Anita Mynett;Elizabeth Hirst

  • Complementation of a mutant cell line : central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

    Mathias Müller;Carl Laxton;James Briscoe;Chris Schindler

  • Morphogen rules: design principles of gradient-mediated embryo patterning.

    James Briscoe;Stephen Small

  • A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

    James Briscoe;Yu Chen;Yu Chen;Thomas M. Jessell;Gary Struhl

  • Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.

    J Ericson;J Briscoe;P Rashbass;V van Heyningen

  • In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

    Mina Gouti;Anestis Tsakiridis;Filip J. Wymeersch;Yali Huang

  • SOX9 induces and maintains neural stem cells

    Charlotte E Scott;Sarah L Wynn;Sarah L Wynn;Abdul Sesay;Catarina Cruz

  • Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

    Madelen Persson;Despina Stamataki;Pascal te Welscher;Elisabet Andersson

Frequent Co-Authors

Johan Ericson
Johan Ericson Karolinska Institute
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute
Bennett G. Novitch
Bennett G. Novitch University of California, Los Angeles
Peter Sollich
Peter Sollich University of Göttingen
Robin Lovell-Badge
Robin Lovell-Badge The Francis Crick Institute
David G. Wilkinson
David G. Wilkinson The Francis Crick Institute
Andreas Schedl
Andreas Schedl Grenoble Alpes University
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Kathryn S. E. Cheah
Kathryn S. E. Cheah University of Hong Kong
Ian M. Kerr
Ian M. Kerr The Honourable Society of Lincoln's Inn

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