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Biology and Biochemistry

D-Index
82
Citations
29704
World Ranking
3642
National Ranking
1816

Overview

Peter J. Roach is affiliated with Indiana University in the United States. Their academic work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Rheumatology, Physiology, Molecular Biology, Organic Chemistry, and Genetics.

Their research topics include Glycogen Storage Diseases and Myoclonus, Lysosomal Storage Disorders Research, Carbohydrate Chemistry and Synthesis, Genetics and Neurodevelopmental Disorders, Amino Acid Enzymes and Metabolism, Neurological Disorders and Treatments, and Pancreatic Function and Diabetes.

Peter J. Roach has authored several recent papers, including:

  • Brain glycogen serves as a critical glucosamine cache required for protein glycosylation, 2021, Cell Metabolism
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase, 2020, Journal of Medicinal Chemistry
  • Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders, 2024, Science Translational Medicine
  • The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex, 2022, Cell Reports
  • GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease, 2020, Annals of Clinical and Translational Neurology

Frequent publication venues for their work include:

  • Cell Metabolism
  • Journal of Medicinal Chemistry
  • Science Translational Medicine
  • Cell Reports
  • Journal of Biological Chemistry

Peter J. Roach has collaborated frequently with several co-authors, notably:

  • Anna Depaoli-Roach
  • Thomas D. Hurley
  • Dyann M. Segvich
  • K.K. Mahalingan
  • Buyun Tang

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Glycogen and its metabolism: some new developments and old themes.

    Peter J. Roach;Anna A. Depaoli-Roach;Thomas D. Hurley;Vincent S. Tagliabracci

  • Glycogen and its Metabolism

    Peter J Roach

  • Multisite and hierarchal protein phosphorylation

    Peter Roach

  • Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

    C. J. Fiol;A. M. Mahrenholz;Y. Wang;R. W. Roeske

  • Phosphate groups as substrate determinants for casein kinase I action.

    Horst Flotow;Paul R. Graves;Aiqun Wang;Carol J. Fiol

  • Regulation of glycogen metabolism in yeast and bacteria.

    Wayne A. Wilson;Peter J. Roach;Manuel Montero;Edurne Baroja-Fernández

  • Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

    Q M Wang;C J Fiol;A A DePaoli-Roach;P J Roach

  • Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

    Simone Weyand;Tatsuro Shimamura;Tatsuro Shimamura;Shunsuke Yajima;Shun'ichi Suzuki

  • A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

    C J Fiol;J S Williams;C H Chou;Q M Wang

  • New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

    John C Lawrence;Peter J Roach

  • Control of glycogen synthase by hierarchal protein phosphorylation.

    Peter J. Roach

  • Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p

    Zhong Wang;Wayne A. Wilson;Marie A. Fujino;Peter J. Roach

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Role of COOH-terminal Phosphorylation in the Regulation of Casein Kinase Iδ (∗)

    Paul R. Graves;Peter J. Roach

  • Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

    Vincent S. Tagliabracci;Julie Turnbull;Wei Wang;Wei Wang;Jean Marie Girard

  • Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates.

    C. J. Fiol;Aiqun Wang;R. W. Roeske;P. J. Roach

  • Purification and characterization of a rabbit liver calmodulin-dependent protein kinase able to phosphorylate glycogen synthase.

    Z Ahmad;A A DePaoli-Roach;P J Roach

  • Role of acidic residues as substrate determinants for casein kinase I.

    Horst Flotow;Peter Roach

Frequent Co-Authors

Anna A. DePaoli-Roach
Anna A. DePaoli-Roach Indiana University
Thomas D. Hurley
Thomas D. Hurley Indiana University
Berge A. Minassian
Berge A. Minassian The University of Texas Southwestern Medical Center
Alan D. Cherrington
Alan D. Cherrington Vanderbilt University
John C. Lawrence
John C. Lawrence University of Virginia
Evelina Gatti
Evelina Gatti Aix-Marseille University
Nina Raben
Nina Raben National Institutes of Health
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Yee-Joo Tan
Yee-Joo Tan National University of Singapore
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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