World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11340
World Ranking
13245
National Ranking
5640

Chemistry

D-Index
57
Citations
11006
World Ranking
11136
National Ranking
3042

Thomas D. Hurley publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Thomas D. Hurley sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 222 publications — 40th percentile

40% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Thomas D. Hurley D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Thomas D. Hurley sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 57 D-Index — 39th percentile

39% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Thomas D. Hurley is affiliated with Indiana University in the United States. Their primary research fields encompass Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on Rheumatology, Cancer Research, Molecular Biology, Physiology, and Oncology.

Their research covers a range of topics including:

  • Glycogen Storage Diseases and Myoclonus
  • Lysosomal Storage Disorders Research
  • Cancer Cells and Metastasis
  • Cancer, Hypoxia, and Metabolism
  • Carbohydrate Chemistry and Synthesis
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation

Hurley has published multiple papers in diverse scientific venues, with repeated publications in journals such as Cancers and Cancer Research. Other notable publication venues include Cell Metabolism, Journal of Medicinal Chemistry, and Science Translational Medicine.

Recent papers by Hurley include:

  • Brain glycogen serves as a critical glucosamine cache required for protein glycosylation, 2021, Cell Metabolism
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase, 2020, Journal of Medicinal Chemistry
  • Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies, 2020, Cancers
  • Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders, 2024, Science Translational Medicine
  • The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic, 2020, Epilepsy & Behavior

Frequent co-authors collaborating with Hurley include:

  • Anna Depaoli-Roach
  • Peter J. Roach
  • Vaishnavi Muralikrishnan
  • Kenneth P. Nephew
  • Dyann M. Segvich

Their scientific work integrates studies on glycogen metabolism and related diseases, cancer biology including aspects of cancer stem cells and hypoxia, as well as molecular mechanisms linked to epigenetics and neurodevelopmental disorders. These interdisciplinary efforts contribute to ongoing research in understanding and addressing complex biological processes and disease mechanisms.

Best Publications

  • Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

    Che Hong Chen;Grant R. Budas;Eric N. Churchill;Marie Hélène Disatnik

  • Glycogen and its metabolism: some new developments and old themes.

    Peter J. Roach;Anna A. Depaoli-Roach;Thomas D. Hurley;Vincent S. Tagliabracci

  • Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application

    Vindhya Koppaka;David C. Thompson;Ying Chen;Manuel Ellermann

  • Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

    Junjie Li;Salvatore Condello;Jessica Thomes-Pepin;Xiaoxiao Ma

  • Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.

    Curtis G Steinmetz;Peiguang Xie;Henry Weiner;Thomas D Hurley

  • Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

    Samantha Perez-Miller;Hina Younus;Ram Vanam;Che Hong Chen

  • Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

    Zejin Sun;Daryl J. Murry;Sonal P. Sanghani;Wilhelmina I. Davis

  • Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

    Samantha J Perez-Miller;Thomas D Hurley

  • Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2

    Thomas D. Hurley;Jie Yang;Lili Zhang;Kristie D. Goodwin

  • β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.

    Salvatore Condello;Cynthia A. Morgan;Sarbajeet Nagdas;Liyun Cao

  • Hydrolysis of Capecitabine to 5′-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide

    Sara K Quinney;Sonal P Sanghani;Wilhelmina I Davis;Thomas D. Hurley

  • Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction.

    Zhong‐Ning ‐N Yang;Gerard J. Davis;Thomas D. Hurley;Carol L. Stone

  • The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum

    Brandy L. Akin;Thomas D. Hurley;Zhenhui Chen;Larry R. Jones

  • Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.

    Kenton L. Longenecker;Peter J. Roach;Thomas D. Hurley

  • Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

    Jonathan A. Doorn;Thomas D. Hurley;Dennis R. Petersen

  • Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.

    Brian J. Gibbons;Peter J. Roach;Thomas D. Hurley

  • Hominids adapted to metabolize ethanol long before human-directed fermentation

    Matthew A. Carrigan;Oleg Uryasev;Carole B. Frye;Blair L. Eckman

  • Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.

    Heather N. Larson;Henry Weiner;Thomas D. Hurley

  • Genes Encoding Enzymes Involved in Ethanol Metabolism

    Thomas D Hurley;Howard J Edenberg

  • N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

    Cynthia A. Morgan;Bibek Parajuli;Cameron D. Buchman;Karl Dria

  • Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

    Heather N. Larson;Jianzhong Zhou;Zhiqiang Chen;Jonathan S. Stamler

  • Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases

    Robert A. Harris;John W. Hawes;Kirill M. Popov;Yu Zhao

Frequent Co-Authors

William F. Bosron
William F. Bosron Indiana University
Peter J. Roach
Peter J. Roach Indiana University
Henry Weiner
Henry Weiner Purdue University West Lafayette
Howard J. Edenberg
Howard J. Edenberg Indiana University
Scott D. Larsen
Scott D. Larsen University of Michigan–Ann Arbor
Ting-Kai Li
Ting-Kai Li Duke University
Anna A. DePaoli-Roach
Anna A. DePaoli-Roach Indiana University
Daria Mochly-Rosen
Daria Mochly-Rosen Stanford University
Duxin Sun
Duxin Sun University of Michigan–Ann Arbor
Steven A. Benner
Steven A. Benner University of Florida

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