World's Best Scientists 2026 revealed!

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Chemistry

D-Index
57
Citations
11006
World Ranking
11138
National Ranking
3043

Biology and Biochemistry

D-Index
58
Citations
11340
World Ranking
13245
National Ranking
5640

Overview

Thomas D. Hurley is affiliated with Indiana University in the United States. Their primary research fields encompass Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on Rheumatology, Cancer Research, Molecular Biology, Physiology, and Oncology.

Their research covers a range of topics including:

  • Glycogen Storage Diseases and Myoclonus
  • Lysosomal Storage Disorders Research
  • Cancer Cells and Metastasis
  • Cancer, Hypoxia, and Metabolism
  • Carbohydrate Chemistry and Synthesis
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation

Hurley has published multiple papers in diverse scientific venues, with repeated publications in journals such as Cancers and Cancer Research. Other notable publication venues include Cell Metabolism, Journal of Medicinal Chemistry, and Science Translational Medicine.

Recent papers by Hurley include:

  • Brain glycogen serves as a critical glucosamine cache required for protein glycosylation, 2021, Cell Metabolism
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase, 2020, Journal of Medicinal Chemistry
  • Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies, 2020, Cancers
  • Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders, 2024, Science Translational Medicine
  • The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic, 2020, Epilepsy & Behavior

Frequent co-authors collaborating with Hurley include:

  • Anna Depaoli-Roach
  • Peter J. Roach
  • Vaishnavi Muralikrishnan
  • Kenneth P. Nephew
  • Dyann M. Segvich

Their scientific work integrates studies on glycogen metabolism and related diseases, cancer biology including aspects of cancer stem cells and hypoxia, as well as molecular mechanisms linked to epigenetics and neurodevelopmental disorders. These interdisciplinary efforts contribute to ongoing research in understanding and addressing complex biological processes and disease mechanisms.

Best Publications

  • Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

    Che Hong Chen;Grant R. Budas;Eric N. Churchill;Marie Hélène Disatnik

  • Glycogen and its metabolism: some new developments and old themes.

    Peter J. Roach;Anna A. Depaoli-Roach;Thomas D. Hurley;Vincent S. Tagliabracci

  • Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application

    Vindhya Koppaka;David C. Thompson;Ying Chen;Manuel Ellermann

  • Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

    Junjie Li;Salvatore Condello;Jessica Thomes-Pepin;Xiaoxiao Ma

  • Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.

    Curtis G Steinmetz;Peiguang Xie;Henry Weiner;Thomas D Hurley

  • Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

    Samantha Perez-Miller;Hina Younus;Ram Vanam;Che Hong Chen

  • Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

    Zejin Sun;Daryl J. Murry;Sonal P. Sanghani;Wilhelmina I. Davis

  • Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

    Samantha J Perez-Miller;Thomas D Hurley

  • Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2

    Thomas D. Hurley;Jie Yang;Lili Zhang;Kristie D. Goodwin

  • β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.

    Salvatore Condello;Cynthia A. Morgan;Sarbajeet Nagdas;Liyun Cao

  • Hydrolysis of Capecitabine to 5′-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide

    Sara K Quinney;Sonal P Sanghani;Wilhelmina I Davis;Thomas D. Hurley

  • Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction.

    Zhong‐Ning ‐N Yang;Gerard J. Davis;Thomas D. Hurley;Carol L. Stone

  • The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum

    Brandy L. Akin;Thomas D. Hurley;Zhenhui Chen;Larry R. Jones

  • Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.

    Kenton L. Longenecker;Peter J. Roach;Thomas D. Hurley

  • Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

    Jonathan A. Doorn;Thomas D. Hurley;Dennis R. Petersen

  • Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.

    Brian J. Gibbons;Peter J. Roach;Thomas D. Hurley

  • Hominids adapted to metabolize ethanol long before human-directed fermentation

    Matthew A. Carrigan;Oleg Uryasev;Carole B. Frye;Blair L. Eckman

  • Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.

    Heather N. Larson;Henry Weiner;Thomas D. Hurley

  • Genes Encoding Enzymes Involved in Ethanol Metabolism

    Thomas D Hurley;Howard J Edenberg

  • N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

    Cynthia A. Morgan;Bibek Parajuli;Cameron D. Buchman;Karl Dria

  • Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

    Heather N. Larson;Jianzhong Zhou;Zhiqiang Chen;Jonathan S. Stamler

  • Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases

    Robert A. Harris;John W. Hawes;Kirill M. Popov;Yu Zhao

Frequent Co-Authors

William F. Bosron
William F. Bosron Indiana University
Peter J. Roach
Peter J. Roach Indiana University
Henry Weiner
Henry Weiner Purdue University West Lafayette
Howard J. Edenberg
Howard J. Edenberg Indiana University
Scott D. Larsen
Scott D. Larsen University of Michigan–Ann Arbor
Ting-Kai Li
Ting-Kai Li Duke University
Anna A. DePaoli-Roach
Anna A. DePaoli-Roach Indiana University
Daria Mochly-Rosen
Daria Mochly-Rosen Stanford University
Duxin Sun
Duxin Sun University of Michigan–Ann Arbor
Steven A. Benner
Steven A. Benner University of Florida

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