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Anna A. DePaoli-Roach

Anna A. DePaoli-Roach

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
12917
World Ranking
7187
National Ranking
3297

Overview

Anna A. DePaoli-Roach is affiliated with Indiana University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in related subfields such as Rheumatology, Physiology, Organic Chemistry, Molecular Biology, and Biochemistry.

The scientist's work focuses on topics including Glycogen Storage Diseases and Myoclonus, Lysosomal Storage Disorders Research, Carbohydrate Chemistry and Synthesis, Amino Acid Enzymes and Metabolism, Pain Mechanisms and Treatments, Neuroscience and Neuropharmacology Research, and Genetics and Neurodevelopmental Disorders.

Recent publications by Anna A. DePaoli-Roach include:

  • Brain glycogen serves as a critical glucosamine cache required for protein glycosylation (2021), published in Cell Metabolism
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase (2020), published in Journal of Medicinal Chemistry
  • Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders (2024), published in Science Translational Medicine
  • Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain (2024), published in Nature Metabolism
  • The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex (2022), published in Cell Reports

The scientist frequently collaborates with co-authors from related research domains, including:

  • Peter J. Roach
  • Thomas D. Hurley
  • Dyann M. Segvich
  • K.K. Mahalingan
  • Buyun Tang

Anna A. DePaoli-Roach's work has been published in various journals, with multiple publications in the Journal of Biological Chemistry, as well as contributions to Cell Metabolism, Journal of Medicinal Chemistry, Science Translational Medicine, and Nature Metabolism.

Best Publications

  • PKC-alpha regulates cardiac contractility and propensity toward heart failure.

    Julian C Braz;Kimberly Gregory;Anand Pathak;Wen Zhao

  • Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

    Q M Wang;C J Fiol;A A DePaoli-Roach;P J Roach

  • CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.

    A M Healy;S Zolnierowicz;A E Stapleton;M Goebl

  • Type 1 Phosphatase, a Negative Regulator of Cardiac Function

    Andrew N. Carr;Albrecht G. Schmidt;Yoichi Suzuki;Federica Del Monte

  • Dephosphorylation of Sp1 by Protein Phosphatase 1 Is Involved in the Glucose-mediated Activation of the Acetyl-CoA Carboxylase Gene

    Samira Daniel;Shaoying Zhang;Anna A. DePaoli-Roach;Ki-Han Kim

  • Enhancement of Cardiac Function and Suppression of Heart Failure Progression By Inhibition of Protein Phosphatase 1

    Anand Pathak;Federica Del Monte;Wen Zhao;Jo El Schultz

  • The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity

    J A Pitcher;E S Payne;C Csortos;A A DePaoli-Roach

  • Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

    Vincent S. Tagliabracci;Julie Turnbull;Wei Wang;Wei Wang;Jean Marie Girard

  • Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2

    Thomas D. Hurley;Jie Yang;Lili Zhang;Kristie D. Goodwin

  • Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase.

    P M Tang;J A Bondor;K M Swiderek;A A DePaoli-Roach

  • Purification and characterization of a rabbit liver calmodulin-dependent protein kinase able to phosphorylate glycogen synthase.

    Z Ahmad;A A DePaoli-Roach;P J Roach

  • High complexity in the expression of the B′ subunit of protein phosphatase 2A0: Evidence for the existence of at least seven novel isoforms

    Csilla Csortos;Stanislaw Zolnierowicz;Eva Bakó;Stephen D. Durbin

  • Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.

    Yoichi Suzuki;Carita Lanner;Jong-Hwa Kim;Pier Giuseppe Vilardo

  • In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

    E M Dutil;L M Keranen;A A DePaoli-Roach;A C Newton

  • Serine/threonine protein phosphatases in the control of cell function

    Anna A. Depaoli-Roach;In Kyung Park;Vaclav Cerovsky;Csilla Csortos

  • Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways

    Iñaki Azpiazu;Alan R. Saltiel;Anna A. DePaoli-Roach;John C. Jr. Lawrence

  • Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.

    Vincent S. Tagliabracci;Jean Marie Girard;Dyann Segvich;Catalina Meyer

  • Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.

    P.R. Graves;D.W. Haas;C.H. Hagedorn;A.A. DePaoli-Roach

  • Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

    Nam Ho Jeoung;Pengfei Wu;Mandar A. Joshi;Jerzy Jaskiewicz

  • Yeast casein kinase I homologues: an essential gene pair.

    L C Robinson;E J Hubbard;P R Graves;A A DePaoli-Roach

Frequent Co-Authors

Peter J. Roach
Peter J. Roach Indiana University
Thomas D. Hurley
Thomas D. Hurley Indiana University
Evangelia G. Kranias
Evangelia G. Kranias University of Cincinnati Medical Center
Yoichi Suzuki
Yoichi Suzuki Chiba University
John C. Lawrence
John C. Lawrence University of Virginia
Pierre J. Magistretti
Pierre J. Magistretti École Polytechnique Fédérale de Lausanne
Fredrik Karpe
Fredrik Karpe University of Oxford
Antonio Vidal-Puig
Antonio Vidal-Puig University of Cambridge
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Berge A. Minassian
Berge A. Minassian The University of Texas Southwestern Medical Center

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