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Scot A. Marsters

Scot A. Marsters

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
23267
World Ranking
14747
National Ranking
6164

Overview

Scot A. Marsters is affiliated with Genentech in the United States and conducts research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields including molecular biology, cell biology, immunology, epidemiology, and hepatology.

The research topics explored by Marsters focus mainly on endoplasmic reticulum stress and disease, with significant contributions to RNA regulation and disease, autophagy in disease and therapy, immunotherapy and immune responses, ubiquitin and proteasome pathways, RNA research and splicing, and immune cell function and interaction.

Marsters has contributed to multiple scientific publications, with research appearing in frequently visited venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, PLoS Biology, eLife, and Cancer Research.

Notable recent papers include:

  • Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress, 2020, eLife
  • IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment, 2020, Cancer Research
  • Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α, 2021, Nature Communications
  • Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation, 2022, The Journal of Cell Biology
  • A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis, 2022, Cell Metabolism

Marsters collaborates frequently with several coauthors, including Avi Ashkenazi, Zora Modrušan, David A. Lawrence, Adrien Le Thomas, and Joachim Rudolph.

Best Publications

  • Safety and antitumor activity of recombinant soluble Apo2 ligand

    Avi Ashkenazi;Roger C. Pai;Sharon Fong;Susan Leung

  • Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family *

    Robert M. Pitti;Scot A. Marsters;Siegfried Ruppert;Christopher J. Donahue

  • Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

    James P. Sheridan;Scot A. Marsters;Robert M. Pitti;Austin Gurney

  • Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

    Robert M. Pitti;Scot A. Marsters;David A. Lawrence;Margaret Roy

  • Designing CD4 immunoadhesins for AIDS therapy

    Daniel J. Capon;Steven M. Chamow;Joyce Mordenti;Scot A. Marsters

  • Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

    David Lawrence;Zahra Shahrokh;Scot Marsters;Kirsten Achilles

  • A novel receptor for Apo2L/TRAIL contains a truncated death domain

    S.A. Marsters;J.P. Sheridan;R.M. Pitti;A. Huang

  • Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

    Steven Shak;Daniel J. Capon;Renate Hellmiss;Scot A. Marsters

  • Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

    Douglas H. Smith;Randal A. Byrn;Scot A. Marsters;Timothy Gregory

  • Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.

    Min Lu;David A. Lawrence;Scot Marsters;Diego Acosta-Alvear

  • Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

    Clara Montagut;Alba Dalmases;Beatriz Bellosillo;Marta Crespo

  • Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

    A Ashkenazi;S A Marsters;D J Capon;S M Chamow

  • Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI.

    Scot A Marsters;Minhong Yan;Robert M Pitti;Philip E Haas

  • Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.

    S A Marsters;T M Ayres;M Skubatch;C L Gray

  • Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

    Scot A. Marsters;James P. Sheridan;Christopher J. Donahue;Robert M. Pitti

  • A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors.

    Donna Oksenberg;Scot A. Marsters;Brian F. O'Dowd;Hui Jin

  • An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

    Nicholas S. Wilson;Becky Yang;Annie Yang;Stefanie Loeser

  • Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.

    Avi Ashkenazi;L. G. Presta;S. A. Marsters;T. R. Camerato

  • Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity.

    Minhong Yan;Scot A. Marsters;Iqbal S. Grewal;Hua Wang

  • Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

    Jing Qing;Xiangnan Du;Yongmei Chen;Pamela Chan

Frequent Co-Authors

Audrey Goddard
Audrey Goddard Gilead Sciences
Iqbal S. Grewal
Iqbal S. Grewal Johnson & Johnson
Daniel J. Capon
Daniel J. Capon LabCorp (United States)
Peter Walter
Peter Walter University of California, San Francisco
Florian M. Wurm
Florian M. Wurm École Polytechnique Fédérale de Lausanne
Germaine Fuh
Germaine Fuh Genentech

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