D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 15,027 287 World Ranking 4252 National Ranking 70

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

His scientific interests lie mostly in Protein kinase B, PI3K/AKT/mTOR pathway, Cell biology, Cancer research and Signal transduction. His Protein kinase B research is multidisciplinary, relying on both Inhibitor of apoptosis, XIAP and Caspase 8. His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in Cancer stem cell and Targeted therapy.

While the research belongs to areas of Cell biology, Lucio Cocco spends his time largely on the problem of Biochemistry, intersecting his research to questions surrounding Cell culture. His Cancer research research includes themes of GSK-3, Immunology, PTEN and MAPK/ERK pathway. His studies deal with areas such as Leukemia and Cell growth as well as Signal transduction.

His most cited work include:

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health (423 citations)
  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging (416 citations)
  • Multiple roles of phosphoinositide-specific phospholipase C isozymes. (371 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Cancer research, Signal transduction, Biochemistry and Phospholipase C. The concepts of his Cell biology study are interwoven with issues in Cellular differentiation and Cell growth. His Cancer research research is multidisciplinary, incorporating perspectives in Immunology, Protein kinase B, PI3K/AKT/mTOR pathway and Myelodysplastic syndromes.

His PI3K/AKT/mTOR pathway research is multidisciplinary, relying on both Cancer stem cell, Targeted therapy and MAPK/ERK pathway. His research integrates issues of Cell cycle, Gene expression and Cyclin D3 in his study of Signal transduction. Lucio Cocco has included themes like Phospholipase, Molecular biology, Isozyme and Gene isoform in his Phospholipase C study.

He most often published in these fields:

  • Cell biology (35.68%)
  • Cancer research (24.76%)
  • Signal transduction (24.27%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cancer research (24.76%)
  • Cell biology (35.68%)
  • Signal transduction (24.27%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cancer research, Cell biology, Signal transduction, Myelodysplastic syndromes and Internal medicine. His Cancer research study integrates concerns from other disciplines, such as Cancer, Pancreatic cancer, Protein kinase B, Immunology and PI3K/AKT/mTOR pathway. His Protein kinase B study deals with PTEN intersecting with Cancer stem cell.

His study in Cell biology is interdisciplinary in nature, drawing from both Cell cycle, Biochemistry and Cellular differentiation. His Signal transduction study combines topics in areas such as Regulation of gene expression and Targeted therapy. The various areas that Lucio Cocco examines in his Internal medicine study include Endocrinology, Transcription factor and Oncology.

Between 2014 and 2021, his most popular works were:

  • Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. (86 citations)
  • Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer (85 citations)
  • PLC and PI3K/Akt/mTOR signalling in disease and cancer (85 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His primary areas of investigation include Cell biology, Cancer research, Signal transduction, PI3K/AKT/mTOR pathway and Cellular differentiation. The Cell biology study combines topics in areas such as Cell cycle and Biochemistry, Cell growth. His studies in Cancer research integrate themes in fields like Cancer, Metastasis, Pancreatic cancer, Cannabinoid and Immunology.

Lucio Cocco does research in Signal transduction, focusing on Phospholipase C specifically. His research in PI3K/AKT/mTOR pathway intersects with topics in Protein kinase B and MAPK/ERK pathway. Lucio Cocco has researched Cellular differentiation in several fields, including Myocyte, Cell nucleus and C2C12.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Linda S. Steelman;William H. Chappell;Stephen L. Abrams;C. Ruth Kempf.
Aging (Albany NY) (2011)

654 Citations

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf.
Oncotarget (2011)

564 Citations

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Pann-Ghill Suh;Jae-Il Park;Lucia Manzoli;Lucio Cocco.
Journal of Biochemistry and Molecular Biology (2008)

503 Citations

Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

Alberto M. Martelli;R. Stewart Gilmour;Valeria Bertagnolo;Luca M. Neri.
Nature (1992)

450 Citations

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

A M Martelli;M Nyåkern;G Tabellini;R Bortul.
Leukemia (2006)

424 Citations

Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

L Cocco;R S Gilmour;A Ognibene;A J Letcher.
Biochemical Journal (1987)

406 Citations

GSK-3 as potential target for therapeutic intervention in cancer.

James A. McCubrey;Linda S. Steelman;Fred E. Bertrand;Nicole Marie Davis.
Oncotarget (2014)

399 Citations

NK cells and cancer.

Loris Zamai;Cristina Ponti;Prisco Mirandola;Giuliana Gobbi.
Journal of Immunology (2007)

347 Citations

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

James Andrew McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams.
Oncotarget (2012)

310 Citations

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response

James A McCubrey;Linda S Steelman;William H Chappell;Stephen L Abrams.
Oncotarget (2012)

300 Citations

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