His scientific interests lie mostly in Protein kinase B, PI3K/AKT/mTOR pathway, Cell biology, Cancer research and Signal transduction. His Protein kinase B research is multidisciplinary, relying on both Inhibitor of apoptosis, XIAP and Caspase 8. His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in Cancer stem cell and Targeted therapy.
While the research belongs to areas of Cell biology, Lucio Cocco spends his time largely on the problem of Biochemistry, intersecting his research to questions surrounding Cell culture. His Cancer research research includes themes of GSK-3, Immunology, PTEN and MAPK/ERK pathway. His studies deal with areas such as Leukemia and Cell growth as well as Signal transduction.
His primary areas of study are Cell biology, Cancer research, Signal transduction, Biochemistry and Phospholipase C. The concepts of his Cell biology study are interwoven with issues in Cellular differentiation and Cell growth. His Cancer research research is multidisciplinary, incorporating perspectives in Immunology, Protein kinase B, PI3K/AKT/mTOR pathway and Myelodysplastic syndromes.
His PI3K/AKT/mTOR pathway research is multidisciplinary, relying on both Cancer stem cell, Targeted therapy and MAPK/ERK pathway. His research integrates issues of Cell cycle, Gene expression and Cyclin D3 in his study of Signal transduction. Lucio Cocco has included themes like Phospholipase, Molecular biology, Isozyme and Gene isoform in his Phospholipase C study.
The scientist’s investigation covers issues in Cancer research, Cell biology, Signal transduction, Myelodysplastic syndromes and Internal medicine. His Cancer research study integrates concerns from other disciplines, such as Cancer, Pancreatic cancer, Protein kinase B, Immunology and PI3K/AKT/mTOR pathway. His Protein kinase B study deals with PTEN intersecting with Cancer stem cell.
His study in Cell biology is interdisciplinary in nature, drawing from both Cell cycle, Biochemistry and Cellular differentiation. His Signal transduction study combines topics in areas such as Regulation of gene expression and Targeted therapy. The various areas that Lucio Cocco examines in his Internal medicine study include Endocrinology, Transcription factor and Oncology.
His primary areas of investigation include Cell biology, Cancer research, Signal transduction, PI3K/AKT/mTOR pathway and Cellular differentiation. The Cell biology study combines topics in areas such as Cell cycle and Biochemistry, Cell growth. His studies in Cancer research integrate themes in fields like Cancer, Metastasis, Pancreatic cancer, Cannabinoid and Immunology.
Lucio Cocco does research in Signal transduction, focusing on Phospholipase C specifically. His research in PI3K/AKT/mTOR pathway intersects with topics in Protein kinase B and MAPK/ERK pathway. Lucio Cocco has researched Cellular differentiation in several fields, including Myocyte, Cell nucleus and C2C12.
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Linda S. Steelman;William H. Chappell;Stephen L. Abrams;C. Ruth Kempf.
Aging (Albany NY) (2011)
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf.
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
Pann-Ghill Suh;Jae-Il Park;Lucia Manzoli;Lucio Cocco.
Journal of Biochemistry and Molecular Biology (2008)
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
Alberto M. Martelli;R. Stewart Gilmour;Valeria Bertagnolo;Luca M. Neri.
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
A M Martelli;M Nyåkern;G Tabellini;R Bortul.
Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation
L Cocco;R S Gilmour;A Ognibene;A J Letcher.
Biochemical Journal (1987)
GSK-3 as potential target for therapeutic intervention in cancer.
James A. McCubrey;Linda S. Steelman;Fred E. Bertrand;Nicole Marie Davis.
NK cells and cancer.
Loris Zamai;Cristina Ponti;Prisco Mirandola;Giuliana Gobbi.
Journal of Immunology (2007)
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
James Andrew McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams.
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response
James A McCubrey;Linda S Steelman;William H Chappell;Stephen L Abrams.
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