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Biology and Biochemistry

D-Index
56
Citations
12090
World Ranking
14371
National Ranking
430

Overview

Melchiorre Cervello is a researcher affiliated with the National Research Council (CNR) in Italy. Their scientific contributions span fields including Medicine and Biochemistry, Genetics and Molecular Biology, with particular focus on subfields such as Molecular Biology, Oncology, Epidemiology, Hepatology, and Cell Biology.

Their research extensively covers topics related to cancer and liver diseases, focusing on molecular pathways and signaling mechanisms. Key areas of study include:

  • Cancer-related Molecular Pathways
  • Liver Disease Diagnosis and Treatment
  • Wnt/β-catenin signaling in development and cancer
  • PI3K/AKT/mTOR signaling in cancer
  • Cholesterol and Lipid Metabolism
  • Epigenetics and DNA Methylation
  • COVID-19 Clinical Research Studies

Notable recent publications featuring Melchiorre Cervello as author or coauthor include:

  • New landscapes and horizons in hepatocellular carcinoma therapy, 2020, Aging
  • Targeting GSK3 and Associated Signaling Pathways Involved in Cancer, 2020, Cells
  • The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment, 2020, Cells
  • Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies, 2021, International Journal of Molecular Sciences
  • Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression, 2022, Cells

Frequent collaborators in their research include:

  • Giuseppa Augello
  • Giuseppe Montalto
  • James A. McCubrey
  • Lydia Giannitrapani
  • Maurizio Soresi

Melchiorre Cervello has published in several scientific venues, with a concentration of works appearing in:

  • Advances in Biological Regulation
  • Cells
  • International Journal of Molecular Sciences
  • Aging
  • Journal of Hepatology

Best Publications

  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

    Linda S. Steelman;William H. Chappell;Stephen L. Abrams;C. Ruth Kempf

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

    William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf

  • GSK-3 as potential target for therapeutic intervention in cancer.

    James A. McCubrey;Linda S. Steelman;Fred E. Bertrand;Nicole Marie Davis

  • Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

    Monica Notarbartolo;Paola Poma;Daniela Perri;Luisa Dusonchet

  • Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response

    James A McCubrey;Linda S Steelman;William H Chappell;Stephen L Abrams

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

    James Andrew McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams

  • Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

    Nicole Marie Davis;Melissa Sokolosky;Kristin Stadelman;Stephen L. Abrams

  • Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

    James A. McCubrey;L. S. Steelman;Fred E. Bertrand;Nicole Marie Davis

  • Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

    Negin Misaghian;Giovanni Ligresti;L. S. Steelman;Fred E. Bertrand

  • The tumor microenvironment in hepatocellular carcinoma (review).

    Giulia Costanza Leonardi;Saverio Candido;Melchiorre Cervello;Daria Nicolosi

  • Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

    James A. McCubrey;Kvin Lertpiriyapong;Linda S. Steelman;Steve L. Abrams

  • Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

    Przemysław Duda;Shaw M. Akula;Stephen L. Abrams;Linda S. Steelman

  • Targeted therapy for hepatocellular carcinoma: novel agents on the horizon

    Melchiorre Cervello;James A McCubrey;Antonella Cusimano;Nadia Lampiasi

  • Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

    James A. McCubrey;Linda S. Steelman;C. Ruth Kempf;William H. Chappell

  • Molecular mechanisms of sorafenib action in liver cancer cells

    Melchiorre Cervello;Dimcho Bachvarov;Nadia Lampiasi;Antonella Cusimano

  • Akt as a therapeutic target in cancer.

    Linda S Steelman;Kristin M Stadelman;William H Chappell;Stefan Horn

  • Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways.

    Cecilia Scisciani;Stefania Vossio;Francesca Guerrieri;Valeria Schinzari

  • Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer

    James A. McCubrey;Dariusz Rakus;Agnieszka Gizak;Linda S. Steelman

  • Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

    Timothy L. Fitzgerald;Kvin Lertpiriyapong;Lucio Cocco;Alberto M. Martelli

  • Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis.

    James A. McCubrey;Stephen L. Abrams;Timothy L. Fitzgerald;Lucio Cocco

Frequent Co-Authors

Giuseppe Montalto
Giuseppe Montalto University of Palermo
James A. McCubrey
James A. McCubrey East Carolina University
Massimo Libra
Massimo Libra University of Catania
Alberto M. Martelli
Alberto M. Martelli University of Bologna
Lucio Cocco
Lucio Cocco University of Bologna
Gaetano Giammona
Gaetano Giammona University of Palermo
Pedro Luiz Rosalen
Pedro Luiz Rosalen State University of Campinas
Kazuo Umezawa
Kazuo Umezawa Aichi Medical University
Michele Milella
Michele Milella University of Verona
Richard A. Franklin
Richard A. Franklin East Carolina University

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