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Neuroscience

D-Index
49
Citations
15731
World Ranking
5858
National Ranking
2572

Overview

Gareth R. Howell is affiliated with The Jackson Laboratory in the United States. Their research spans multiple fields including Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. These domains broadly cover neurological and molecular biological aspects of disease and physiology.

Their work primarily focuses on topics related to Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, as well as bioinformatics and genomic networks. Additional areas of interest include neurological disease mechanisms and treatments, nuclear receptors and signaling, tryptophan and brain disorders, and retinal diseases and treatments.

Howell's recent published papers include:

  • Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models, 2020, Cell Reports
  • Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study, 2021, Frontiers in Aging Neuroscience
  • Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank, 2020, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD, 2020, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease, 2021, Cell Reports

Collaborations have been established with several frequent coauthors, including Michael Sasner, Gregory W. Carter, Kevin P. Kotredes, Bruce T. Lamb, and Adrian L. Oblak.

The scientist has published extensively in prominent venues such as Alzheimer s & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Aging Neuroscience, Alzheimer s & Dementia Translational Research & Clinical Interventions, and Cell Reports.

Subfields of Howell's research include neurology, physiology, molecular biology, ophthalmology, and rheumatology, indicating a broad interdisciplinary approach that integrates neurological and biological specialties across various systems.

Best Publications

  • The classical complement cascade mediates CNS synapse elimination.

    Beth Stevens;Nicola J. Allen;Luis E. Vazquez;Gareth R. Howell

  • TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

    Taylor R. Jay;Crystal M Miller;Paul J Cheng;Leah C Graham

  • Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

    Gareth R. Howell;Richard T. Libby;Tatjana C. Jakobs;Richard S. Smith

  • Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

    Gareth R. Howell;Danilo G. Macalinao;Gregory L. Sousa;Michael Walden

  • A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation

    A. Carrie;L. Jun;T. Bienvenu;M.C. Vinet

  • Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

    Chad A. Tagge;Andrew M. Fisher;Olga V. Minaeva;Amanda Gaudreau-Balderrama

  • Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

    Robert W. Nickells;Gareth R. Howell;Ileana Soto;Simon W.M. John

  • Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.

    Ying-Wooi Wan;Ying-Wooi Wan;Rami Al-Ouran;Rami Al-Ouran;Carl G. Mangleburg;Carl G. Mangleburg;Thanneer M. Perumal

  • Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.

    Adrian L. Oblak;Peter B. Lin;Kevin P. Kotredes;Ravi S. Pandey

  • Genome-wide association analysis identifies TXNRD2 , ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

    Jessica N.Cooke Bailey;Stephanie J. Loomis;Jae H. Kang;R. Rand Allingham

  • Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

    Gareth R. Howell;Ileana Soto;Xianjun Zhu;Margaret Ryan

  • The Complex Role of Neuroinflammation in Glaucoma

    Ileana Soto;Gareth R. Howell

  • Neuroinflammation in glaucoma: A new opportunity.

    Pete A Williams;Nick Marsh-Armstrong;Gareth R Howell;Lasker

  • Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma

    Salil A. Lachke;Fowzan S. Alkuraya;Stephen C. Kneeland;Takbum Ohn

  • Toward more predictive genetic mouse models of Alzheimer's disease.

    Kristen D. Onos;Stacey J. Sukoff Rizzo;Gareth R. Howell;Michael Sasner

  • Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

    Pete A. Williams;James R. Tribble;Keating W. Pepper;Stephen D. Cross

  • APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

    Ileana Soto;Leah C. Graham;Hannah J. Richter;Stephen N. Simeone

  • Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

    Gareth R Howell;Richard T Libby;Jeffrey K Marchant;Lawriston A Wilson

  • Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

    Pete A. Williams;Gareth R. Howell;Jessica M. Barbay;Catherine E. Braine

  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

    Tin Aung;Tin Aung;Tin Aung;Mineo Ozaki;Takanori Mizoguchi;R. Rand Allingham

  • Intrinsic axonal degeneration pathways are critical for glaucomatous damage

    Gareth R. Howell;Ileana Soto;Richard T. Libby;Simon W.M. John;Simon W.M. John

  • Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

    K Saidas Nair;Mounira Hmani-Aifa;Zain Ali;Alison L Kearney

Frequent Co-Authors

Bruce T. Lamb
Bruce T. Lamb Indiana University
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Chiea Chuen Khor
Chiea Chuen Khor Agency for Science, Technology and Research
Julie Williams
Julie Williams Cardiff University
Ann C. McKee
Ann C. McKee Boston University
Jie Jin Wang
Jie Jin Wang University of Sydney
Kathryn P. Burdon
Kathryn P. Burdon University of Tasmania
Janey L. Wiggs
Janey L. Wiggs Massachusetts Eye and Ear Infirmary
Alon Friedman
Alon Friedman Dalhousie University

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