World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
65
Citations
17715
World Ranking
3095
National Ranking
1442

Biology and Biochemistry

D-Index
65
Citations
17812
World Ranking
9043
National Ranking
4021

Overview

Bruce T. Lamb is affiliated with Indiana University in the United States. Their research primarily focuses on fields including Medicine and Neuroscience, with a significant number of publications spanning these domains.

The researcher's work extends into specialized subfields such as Physiology, Neurology, Molecular Biology, Immunology, and Computational Theory and Mathematics. This range reflects a multidisciplinary approach to scientific inquiry.

Main topics in Bruce T. Lamb's research include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Bioinformatics and Genomic Networks
  • Computational Drug Discovery Methods
  • Tryptophan and brain disorders
  • Medicinal Plants and Neuroprotection
  • Cholinesterase and Neurodegenerative Diseases

Several recent papers highlight contributions to the understanding and modeling of Alzheimer's disease. These include:

  • Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study, 2021, Frontiers in Aging Neuroscience
  • Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank, 2020, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD, 2020, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia, 2021, Neurobiology of Disease
  • Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice, 2020, Molecular Neurodegeneration

Frequent co-authors in their publications include:

  • Adrian L. Oblak
  • Gregory W. Carter
  • Gareth R. Howell
  • Michael Sasner
  • Ravi S. Pandey

Bruce T. Lamb has published extensively in key venues related to aging and neurodegenerative diseases, such as:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Frontiers in Aging Neuroscience
  • Research Square (Research Square)

Best Publications

  • Inflammation as a central mechanism in Alzheimer's disease

    Jefferson W. Kinney;Shane M. Bemiller;Andrew S. Murtishaw;Amanda M. Leisgang

  • ApoE Promotes the Proteolytic Degradation of Aβ

    Qingguang Jiang;C.Y. Daniel Lee;Shweta Mandrekar;Brandy Wilkinson

  • TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

    Taylor R. Jay;Crystal M Miller;Paul J Cheng;Leah C Graham

  • Regulation of tau pathology by the microglial fractalkine receptor

    Kiran Bhaskar;Megan Konerth;Olga N. Kokiko-Cochran;Astrid Cardona

  • Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

    Heather M. Snyder;Roderick A. Corriveau;Suzanne Craft;James E. Faber

  • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

    Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  • Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

    Nicole Maphis;Guixiang Xu;Olga N. Kokiko-Cochran;Shanya Jiang

  • CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

    Sungho Lee;Nicholas H. Varvel;Nicholas H. Varvel;Megan E. Konerth;Guixiang Xu

  • Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

    Taylor R. Jay;Anna M. Hirsch;Margaret L. Broihier;Crystal M. Miller

  • Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

    Bruce T. Lamb;Sangram S. Sisodia;Ann M. Lawler;Hilda H. Slunt

  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

    Kirsten K. Youngren;Douglas Coveney;Xiaoning Peng;Chitralekha Bhattacharya

  • Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

    Chad A. Tagge;Andrew M. Fisher;Olga V. Minaeva;Amanda Gaudreau-Balderrama

  • Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease ☆

    W. H. Yu;A. Kumar;C. Peterhoff;L. Shapiro Kulnane

  • Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.

    Georgia Gunner;Lucas Cheadle;Kasey M Johnson;Pinar Ayata

  • TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

    Shane M. Bemiller;Shane M. Bemiller;Shane M. Bemiller;Tyler J. McCray;Kevin Allan;Shane V. Formica

  • Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

    Kaushik Ghosal;Daniel L. Vogt;Man Liang;Yong Shen

  • Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.

    Adrian L. Oblak;Peter B. Lin;Kevin P. Kotredes;Ravi S. Pandey

  • The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease

    Paul J. Cheng-Hathaway;Paul J. Cheng-Hathaway;Erin G. Reed-Geaghan;Taylor R. Jay;Brad T. Casali;Brad T. Casali

  • The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer's Disease

    Gjumrakch Aliev;Mark A. Smith;Dilara Seyidova;Maxwell Lewis Neal

  • Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.

    Yan Yang;Nicholas H. Varvel;Nicholas H. Varvel;Bruce T. Lamb;Karl Herrup

  • The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

    Kiran Bhaskar;Megan Miller;Alexandra Chludzinski;Karl Herrup

Frequent Co-Authors

Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Gareth R. Howell
Gareth R. Howell The Jackson Laboratory
Gary E. Landreth
Gary E. Landreth Indiana University
James B. Leverenz
James B. Leverenz Cleveland Clinic
Karl Herrup
Karl Herrup Hong Kong University of Science and Technology
John D. Gearhart
John D. Gearhart University of Pennsylvania
Ann C. McKee
Ann C. McKee Boston University
Stephen M. Rao
Stephen M. Rao Cleveland Clinic
Donald L. Price
Donald L. Price Johns Hopkins University
Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research

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