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Chemistry

D-Index
73
Citations
14714
World Ranking
5127
National Ranking
298

Overview

Andrew W. Munro is affiliated with the University of Manchester in the United Kingdom. Their research spans several domains within biochemistry, genetics, molecular biology, pharmacology, toxicology, and pharmaceutics. Munro's work frequently addresses topics related to pharmacogenetics, drug metabolism, tuberculosis research and epidemiology, computational drug discovery methods, steroid chemistry and biochemistry, biochemical and molecular research, metal-catalyzed oxygenation mechanisms, and hemoglobin structure and function.

Their publication record includes contributions to multiple well-regarded scientific journals. Frequent publication venues include:

  • Journal of Medicinal Chemistry (2 publications)
  • Journal of Biological Chemistry (2 publications)
  • Journal of the American Chemical Society (1 publication)
  • International Journal of Molecular Sciences (1 publication)
  • ACS Catalysis (1 publication)

Recent papers authored include:

  • "Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate," 2020, Journal of the American Chemical Society
  • "Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5," 2020, Journal of Medicinal Chemistry
  • "A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism," 2021, International Journal of Molecular Sciences
  • "Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin," 2022, ACS Catalysis
  • "Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches," 2020, Journal of Biological Chemistry

Frequent collaborators of Munro include:

  • Kirsty J. McLean
  • Richard B. Tunnicliffe
  • David Leys
  • Hazel M. Girvan
  • M. Snee

Munro's academic focus is predominantly in biochemistry, genetics, and molecular biology, with a strong secondary emphasis on pharmacology, toxicology, and pharmaceutics. Their subfield engagements are primarily in pharmacology and molecular biology, with additional involvement in infectious diseases, computational theory and mathematics, and spectroscopy.

The main topics covered in Munro's research publications reflect a concentration on pharmacogenetics and drug metabolism, as well as tuberculosis research and epidemiology. Computational methods are also a notable element in their work, particularly in drug discovery, complemented by research on steroid chemistry and biochemical and molecular biological processes.

Best Publications

  • P450 BM3: the very model of a modern flavocytochrome.

    Andrew W Munro;David G Leys;Kirsty J McLean;Ker R Marshall

  • Unusual Cytochrome P450 Enzymes and Reactions

    F. Peter Guengerich;Andrew W. Munro

  • Roles of key active-site residues in flavocytochrome P450 BM3

    Michael A. Noble;Caroline S. Miles;Stephen K. Chapman;Dominikus A. Lysek

  • Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily.

    Andrew W. Munro;Hazel M. Girvan;Kirsty J. McLean

  • Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis

    John W Pickering;Martin P Than;Louise Cullen;Sally Aldous

  • Redox Control of the Catalytic Cycle of Flavocytochrome P-450 BM3†

    S N Daff;Stephen K Chapman;K L Turner;R A Holt

  • Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology

    Hazel M Girvan;Andrew W Munro

  • Cytochrome P450--redox partner fusion enzymes.

    Andrew W. Munro;Hazel M. Girvan;Kirsty J. McLean

  • What makes a P450 tick

    Andrew W. Munro;Hazel M. Girvan;Amy E. Mason;Adrian J. Dunford

  • Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes

    Kirsty J. McLean;Ker R. Marshall;Alison Richmond;Iain S. Hunter

  • Structure and function of the cytochrome P450 peroxygenase enzymes.

    Andrew W. Munro;Kirsty J. McLean;Job L. Grant;Thomas M. Makris

  • Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

    James Belcher;Kirsty J. McLean;Sarah Matthews;Laura S. Woodward

  • Bacterial cytochromes P-450.

    Andrew W. Munro;J. Gordon Lindsay

  • Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450

    David G Leys;Christopher G. Mowat;Kirsty J McLean;Alison Richmond

  • Determination of the redox properties of human NADPH-cytochrome P450 reductase.

    Andrew W. Munro;Michael A. Noble;Laura Robledo;Simon N. Daff

  • Rational re-design of the substrate binding site of flavocytochrome P450 BM3

    Tobias W B Ost;Caroline S. Miles;Jane Murdoch;York Fong Cheung

  • Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization.

    J S Miles;A W Munro;B N Rospendowski;W E Smith

  • Probing electron transfer in flavocytochrome P-450 BM3 and its component domains.

    Andrew W Munro;Simon N Daff;John R Coggins;J Gordon Lindsay

  • Expression, Purification, and Characterization of Bacillus subtilis Cytochromes P450 CYP102A2 and CYP102A3: Flavocytochrome Homologues of P450 BM3 from Bacillus megaterium

    Mattias C U Gustafsson;Olivier Roitel;Ker R Marshall;Michael A Noble

  • Biochemical and structural insights into bacterial organelle form and biogenesis.

    Joshua B. Parsons;Sriramulu D. Dinesh;Evelyne Deery;Helen K. Leech

  • Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection

    John W. Pickering;Martin P. Than;Louise Cullen;Sally Aldous

Frequent Co-Authors

Kirsty J. McLean
Kirsty J. McLean University of Manchester
David Leys
David Leys University of Manchester
Nigel S. Scrutton
Nigel S. Scrutton University of Manchester
Stephen K Chapman
Stephen K Chapman University of Edinburgh
Stephen E. J. Rigby
Stephen E. J. Rigby University of Manchester
Myles R. Cheesman
Myles R. Cheesman University of East Anglia
Chris Abell
Chris Abell University of Cambridge
John R. Coggins
John R. Coggins University of Glasgow
Martin J. Warren
Martin J. Warren University of Kent
Michael J. Sutcliffe
Michael J. Sutcliffe University of Manchester

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