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Chemistry

D-Index
69
Citations
12861
World Ranking
6377
National Ranking
367

Overview

David Leys is affiliated with the University of Manchester in the United Kingdom. Their research principally spans the field of Biochemistry, Genetics, and Molecular Biology, with 73 publications in this domain. Leys's work delves into specialized subfields including Molecular Biology, Biotechnology, Biochemistry, Organic Chemistry, and Biomedical Engineering.

The scientist's main research topics encompass biochemical and biochemical processes, microbial metabolic engineering and bioproduction, enzyme catalysis and immobilization, biochemical acid research studies, porphyrin metabolism and disorders, photosynthetic processes and mechanisms, as well as biofuel production and bioconversion.

Leys has published several recent papers across various reputable journals, such as:

  • Synthetic Enzyme-Catalyzed CO2 Fixation Reactions, 2021, ChemSusChem
  • A guide to time-resolved structural analysis of light-activated proteins, 2021, FEBS Journal
  • Enzymatic C-H activation of aromatic compounds through CO2 fixation, 2020, Nature Chemical Biology
  • A Vitamin B2-Photocatalysed Approach to Methionine Analogues, 2022, Angewandte Chemie International Edition
  • Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence, 2021, ACS Catalysis

Frequent coauthors collaborating with Leys include:

  • Karl Fisher
  • Sam Hay
  • K.A.P. Payne
  • Stephen Marshall
  • Colin Levy

Key publication venues for Leys comprise:

  • Nature Communications
  • FEBS Journal
  • Journal of Biological Chemistry
  • Nature Chemical Biology
  • Methods in enzymology on CD-ROM/Methods in enzymology

Best Publications

  • P450 BM3: the very model of a modern flavocytochrome.

    Andrew W Munro;David G Leys;Kirsty J McLean;Ker R Marshall

  • The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

    Dea Slade;Mark S. Dunstan;Eva Barkauskaite;Ria Weston

  • Atomic description of an enzyme reaction dominated by proton tunneling

    Laura Masgrau;Anna Roujeinikova;Linus O. Johannissen;Parvinder Hothi

  • Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases

    Laura A. Hug;Farai Maphosa;David Leys;Frank E. Löffler;Frank E. Löffler

  • Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation

    Karl A. P. Payne;Carolina P. Quezada;Karl Fisher;Mark S. Dunstan

  • New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition

    Karl A. P. Payne;Mark D. White;Karl Fisher;Basile Khara

  • UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

    Mark D. White;Karl A. P. Payne;Karl Fisher;Stephen A. Marshall

  • Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1.

    David Leys;Alexandre S. Tsapin;Kenneth H. Nealson;Terrance E. Meyer

  • Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

    James Belcher;Kirsty J. McLean;Sarah Matthews;Laura S. Woodward

  • Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450

    David G Leys;Christopher G. Mowat;Kirsty J McLean;Alison Richmond

  • Reengineering orthogonally selective riboswitches

    Neil Dixon;John N. Duncan;Torsten Geerlings;Mark S. Dunstan

  • Research article: The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms

    Laura R. Kemp;Mark S. Dunstan;Karl Fisher;Jim Warwicker

  • The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase

    Rajasekhar Neeli;Hazel M. Girvan;Andrew Lawrence;Martin J. Warren

  • Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo - and endo -glycohydrolase activities

    Eva Barkauskaite;Amy Brassington;Edwin S. Tan;Jim Warwicker

  • P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

    Carlos G. Acevedo-Rocha;Carlos G. Acevedo-Rocha;Charles G. Gamble;Richard Lonsdale;Richard Lonsdale;Richard Lonsdale;Aitao Li;Aitao Li;Aitao Li

  • Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv

    Kirsty J. McLean;Paul Carroll;D. Geraint Lewis;Adrian J. Dunford

  • Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

    Kirsty J. McLean;Marcus Hans;Ben Meijrink;Wibo B. Van Scheppingen

  • Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

    Shaowei Zhang;Derren J. Heyes;Lingling Feng;Wenli Sun

  • Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

    Harriet E. Seward;Anna Roujeinikova;Kirsty J. McLean;Andrew W. Munro

  • Structural basis of kynurenine 3-monooxygenase inhibition

    Marta Amaral;Colin Levy;Derren J. Heyes;Pierre Lafite

  • Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme.

    Björn V. Adalbjörnsson;Helen S. Toogood;Anna Fryszkowska;Christopher R. Pudney

  • The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

    T.C Terwilliger;M.S Park;G.S Waldo;J Berendzen

  • Extensive Conformational Sampling in a Ternary Electron Transfer Complex.

    David Leys;Jaswir Basran;François Talfournier;Michael J. Sutcliffe

Frequent Co-Authors

Nigel S. Scrutton
Nigel S. Scrutton University of Manchester
Andrew W. Munro
Andrew W. Munro University of Manchester
Kirsty J. McLean
Kirsty J. McLean University of Manchester
Stephen E. J. Rigby
Stephen E. J. Rigby University of Manchester
Terrance E. Meyer
Terrance E. Meyer University of Arizona
Michael J. Sutcliffe
Michael J. Sutcliffe University of Manchester
Michael A. Cusanovich
Michael A. Cusanovich University of Arizona
Myles R. Cheesman
Myles R. Cheesman University of East Anglia
Jason Micklefield
Jason Micklefield University of Manchester
Stephen K Chapman
Stephen K Chapman University of Edinburgh

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