Michael J. Sutcliffe mostly deals with Stereochemistry, Protein structure, Crystallography, Kinetic isotope effect and Cytochrome P450. His work carried out in the field of Stereochemistry brings together such families of science as Chemical physics, Residue, Enzyme, Alanine and Binding site. His Protein structure research incorporates elements of hERG, Potassium channel, Transmembrane domain, KcsA potassium channel and Computational biology.
Michael J. Sutcliffe combines subjects such as Dihedral angle, Coupling constant, Protein secondary structure and Cluster with his study of Crystallography. His Kinetic isotope effect research is multidisciplinary, incorporating elements of Reaction rate, Bond cleavage and Flavin group. His research in Cytochrome P450 intersects with topics in Hydroxylation, Drug detoxification and Heme.
Michael J. Sutcliffe spends much of his time researching Stereochemistry, Biochemistry, Kinetic isotope effect, Active site and Crystallography. His Stereochemistry research focuses on Potassium channel and how it connects with Gating. His study in Cytochrome P450, Homology modeling and Alanine are all subfields of Biochemistry.
His Kinetic isotope effect research is multidisciplinary, incorporating perspectives in Chemical physics, Hydrogen, Quantum tunnelling and Photochemistry. The study incorporates disciplines such as Flavoprotein, Catalysis and Substrate in addition to Photochemistry. His studies in Crystallography integrate themes in fields like Dihedral angle, Protein secondary structure, Molecular dynamics, Nuclear magnetic resonance spectroscopy and Protein structure.
Michael J. Sutcliffe mainly focuses on Stereochemistry, Quantum tunnelling, Kinetic isotope effect, Chemical physics and Morphinone reductase. The concepts of his Stereochemistry study are interwoven with issues in hERG, Crystal structure, Active site, Flavin mononucleotide and Protein structure. Michael J. Sutcliffe interconnects Molecular model and Binding site in the investigation of issues within Protein structure.
His Binding site study which covers Pharmacology that intersects with Biochemistry. As a member of one scientific family, Michael J. Sutcliffe mostly works in the field of Quantum tunnelling, focusing on Enzyme and, on occasion, Saccharomyces cerevisiae and Interactome. His studies deal with areas such as Hydrogen, Molecular dynamics, Methylamine dehydrogenase, Physical chemistry and Photochemistry as well as Kinetic isotope effect.
His scientific interests lie mostly in Stereochemistry, Quantum tunnelling, Morphinone reductase, Kinetic isotope effect and Cytochrome P450. His Stereochemistry study incorporates themes from hERG, Biophysics, Potassium channel, KcsA potassium channel and Kinetics. His Quantum tunnelling study combines topics from a wide range of disciplines, such as Chemical physics, Substrate and Oxidative deamination.
His Kinetic isotope effect study combines topics in areas such as Hydrogen and Methylamine dehydrogenase. His Cytochrome P450 research entails a greater understanding of Enzyme. Michael J. Sutcliffe has researched Catalysis in several fields, including Photochemistry and Proton.
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Knowledge based modelling of homologous proteins, part I: three-dimensional frameworks derived from the simultaneous superposition of multiple structures
M.J. Sutcliffe;I. Haneef;D. Carney;T.L. Blundell.
Protein Engineering (1987)
An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies
Lawrence A. Kelley;Stephen P. Gardner;Michael J. Sutcliffe.
Protein Engineering (1996)
Crystal structure of a PDZ domain
João H. Morais Cabral;Carlo Petosa;Michael J. Sutcliffe;Sami Raza.
Atomic description of an enzyme reaction dominated by proton tunneling
Laura Masgrau;Anna Roujeinikova;Linus O. Johannissen;Parvinder Hothi.
18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design
Tom Blundell;Devon Carney;Stephen Gardner;Fiona Hayes.
FEBS Journal (1988)
Knowledge based modelling of homologous proteins, part II: Rules for the conformations of substituted sidechains
M.J. Sutcliffe;F.R.F. Hayes;T.L. Blundell.
Protein Engineering (1987)
Enzymatic H-Transfer Requires Vibration-Driven Extreme Tunneling†
Jaswir Basran;Michael J. Sutcliffe;Nigel S. Scrutton.
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.
Bradley J. Stevenson;Jaclyn Bibby;Patricia Pignatelli;Sant Muangnoicharoen.
Insect Biochemistry and Molecular Biology (2011)
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
P R Stanfield;N W Davies;P A Shelton;M J Sutcliffe.
The Journal of Physiology (1994)
Ligand Binding to Integrin αIIbβ3 Is Dependent on a MIDAS-like Domain in the β3 Subunit
Eileen Collins Tozer;Robert C. Liddington;Michael J. Sutcliffe;Allister H. Smeeton.
Journal of Biological Chemistry (1996)
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