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Biology and Biochemistry

D-Index
55
Citations
8335
World Ranking
15287
National Ranking
1202

Overview

Lu-Yun Lian is affiliated with the University of Liverpool in the United Kingdom and has contributed to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Computational Mechanics, Genetics, Pulmonary and Respiratory Medicine, and Cardiology and Cardiovascular Medicine.

They have published extensively on topics related to Lattice Boltzmann Simulation Studies, Monoclonal and Polyclonal Antibodies Research, Chronic Lymphocytic Leukemia Research, HER2/EGFR in Cancer Research, Signaling Pathways in Disease, Parkinson's Disease Mechanisms and Treatments, and Alzheimer's disease research and treatments.

Lu-Yun Lian's recent papers include:

  • Identification of β-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation, 2021, Chemical Science
  • Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics, 2020, Scientific Reports
  • BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification, 2023, Molecular Cancer Research
  • CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms, 2021, Journal of Cell Science
  • Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis, 2022, Vaccines

Their work has been published in venues such as arXiv (Cornell University), Chemical Science, Scientific Reports, Molecular Cancer Research, and Journal of Cell Science.

Frequent collaborators in Lu-Yun Lian's research include Oluwatobi Samuel Adegbite, David N. Criddle, Marie Held, S.V. Antonyuk, and Mengru Yang.

Best Publications

  • A simple method for improving protein solubility and long-term stability.

    Alexander P. Golovanov;Guillaume M. Hautbergue;Stuart A. Wilson;Lu Yun Lian

  • Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.

    Bradley J. Stevenson;Jaclyn Bibby;Patricia Pignatelli;Sant Muangnoicharoen

  • A Model for Human Cytochrome P450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding

    S. Modi;M. J. Paine;M. J. Sutcliffe;L. Y. Lian

  • Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP

    Guillaume M. Hautbergue;Ming Lung Hung;Alexander P. Golovanov;Lu Yun Lian

  • A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation

    Catherine F. Oliver;Sandeep Modi;Michael J. Sutcliffe;William U. Primrose

  • Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.

    Yann Hargous;Guillaume M. Hautbergue;Aura M. Tintaru;Aura M. Tintaru;Lenka Skrisovska

  • The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction

    Sandeep Modi;Michael J. Sutcliffe;William U. Primrose;Lu-Yun Lian

  • A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.

    Nicholas H. Keep;Maria Barnes;Igor Barsukov;Ramin Badii

  • The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

    Christian Damblon;Xavier Raquet;Lu-Yun Lian;Josette Lamotte-Brasseur

  • Labelling approaches for protein structural studies by solution-state and solid-state NMR

    Lu-Yun Lian;David A Middleton

  • NMR STUDIES OF SUBSTRATE BINDING TO CYTOCHROME P450 BM3 : COMPARISONS TO CYTOCHROME P450 CAM

    Sandeep Modi;William U. Primrose;James M. B. Boyle;Catherine F. Gibson

  • Isolation and characterisation of two degradation products derived from the peptide antibiotic nisin

    Weng C. Chan;Barrie W. Bycroft;Lu-Yun Lian;Gordon C.K. Roberts

  • Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin

    W.C. Chan;M. Leyland;J. Clark;H.M. Dodd

  • Protein-ligand interactions: exchange processes and determination of ligand conformation and protein-ligand contacts.

    L.Y Lian;I.L Barsukov;M.J Sutcliffe;K.H Sze

  • Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.

    Qiang Zhao;S. Modi;G. Smith;M. Paine

  • Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5.

    W. C. Chan;H. M. Dodd;N. Horn;K. Maclean

  • A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

    David J. Judah;John D. Hayes;Ji-Chun Yang;Lu-Yun Lian

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: Allosteric effects of NADPH-cytochrome P450 reductase

    S. Modi;D.E. Gilham;M.J. Sutcliffe;L.-Y. Lian

  • Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds

    Catherine F. Oliver;Sandeep Modi;William U. Primrose;Lu Yun Lian

  • Model for the complex between protein G and an antibody Fc fragment in solution

    Koichi Kato;Lu Yun Lian;Igor L. Barsukov;Jeremy P. Derrick

Frequent Co-Authors

Gordon C. K. Roberts
Gordon C. K. Roberts University of Leicester
Robert D. Burgoyne
Robert D. Burgoyne University of Liverpool
Michael J. Sutcliffe
Michael J. Sutcliffe University of Manchester
Barrie W. Bycroft
Barrie W. Bycroft University of Nottingham
Mark J. I. Paine
Mark J. I. Paine Liverpool School of Tropical Medicine
Geoffrey R. Moore
Geoffrey R. Moore University of East Anglia
B. Kevin Park
B. Kevin Park University of Liverpool
Nigel S. Scrutton
Nigel S. Scrutton University of Manchester
Colin Kleanthous
Colin Kleanthous University of Oxford
Robert J. Beynon
Robert J. Beynon University of Liverpool

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