World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
9041
World Ranking
15764
National Ranking
1235

Overview

Mark J. I. Paine is affiliated with the Liverpool School of Tropical Medicine in the United Kingdom. Their research primarily spans the fields of Medicine and Agricultural and Biological Sciences, with a particular focus on Public Health, Environmental and Occupational Health, Plant Science, Molecular Biology, Insect Science, and Epidemiology.

Their work addresses key topics within malaria research and control, mosquito-borne diseases and control, insect pest control strategies, insect resistance and genetics, trypanosoma species research and implications, insect symbiosis and bacterial influences, and pharmacogenetics and drug metabolism.

Recent published papers include the following:

  • Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for antimalarial intervention deployment, 2022, Molecular Ecology
  • Assessing cross-resistance within the pyrethroids in terms of their interactions with key cytochrome P450 enzymes and resistance in vector populations, 2021, Parasites & Vectors
  • High pyrethroid/DDT resistance in major malaria vector Anopheles coluzzii from Niger-Delta of Nigeria is probably driven by metabolic resistance mechanisms, 2021, PLoS ONE
  • Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes, 2021, Insects
  • New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids, 2020, Scientific Reports

Frequent co-authors collaborating with Mark J. I. Paine include:

  • Hanafy M. Ismail
  • David Weetman
  • Folasade Oladepo
  • Kyle J. Walker
  • Martin J. Donnelly

The scientist's work is often published in venues such as:

  • Scientific Reports
  • Parasites & Vectors
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • Malaria Journal

Mark J. I. Paine's research contributions cover extensive studies on insecticide resistance mechanisms, especially in malaria vectors such as Anopheles species. Their investigations have explored metabolic resistance, cross-resistance among pyrethroids, and the implications of insecticide interaction with key enzymes. Such studies support efforts in antimalarial intervention deployment and pest control strategies.

Best Publications

  • Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family

    M. J. I. Paine;H. P. Desmond;R. D. G. Theakston;J. M. Crampton

  • Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

    Jean-Philippe David;Hanafy Mahmoud Ismail;Alexia Chandor-Proust;Mark John Ingraham Paine

  • Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids.

    Pie Müller;Emma Warr;Bradley J. Stevenson;Patricia M. Pignatelli

  • CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae.

    Constant V. Edi;Luc Djogbénou;Adam M. Jenkins;Kimberly Regna

  • Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.

    Bradley J. Stevenson;Jaclyn Bibby;Patricia Pignatelli;Sant Muangnoicharoen

  • Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana

    Sara N. Mitchell;Bradley J. Stevenson;Pie Müller;Craig S. Wilding

  • Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus

    Jacob M. Riveron;Helen Irving;Miranda Ndula;Kayla G. Barnes

  • A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.

    Evangelia Morou;Andrew J. Dowd;Shavanthi Rajatileka;Andrew Steven

  • Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance.

    Iris Karunker;Evangelia Morou;Evangelia Morou;Dimitra Nikou;Dimitra Nikou;Ralf Nauen

  • A Model for Human Cytochrome P450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding

    S. Modi;M. J. Paine;M. J. Sutcliffe;L. Y. Lian

  • Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae

    M. Riga;D. Tsakireli;A. Ilias;E. Morou

  • Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: a hypothesis explaining local tissue damage following snake bite.

    Ana Maria Moura-da-Silva;Gavin David Laing;Mark John Ingraham Paine;Jeremy Michael Thomas Jonathan Dennison

  • Pinpointing P450s Associated with Pyrethroid Metabolism in the Dengue Vector, Aedes aegypti: Developing New Tools to Combat Insecticide Resistance

    Bradley J. Stevenson;Patricia Pignatelli;Dimitra Nikou;Mark J. I. Paine

  • Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

    Andrew P. Garner;Mark J. I. Paine;Ignacio Rodriguez-Crespo;Edwin C. Chinje

  • Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

    Mark J.I. Paine;Lesley A. McLaughlin;Jack U. Flanagan;Carol A. Kemp

  • Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae.

    Sara N. Mitchell;Daniel J. Rigden;Andrew J. Dowd;Fang Lu

  • Antimalarial activity of primaquine operates via a two-step biochemical relay.

    Grazia Camarda;Piyaporn Jirawatcharadech;Richard S. Priestley;Richard S. Priestley;Ahmed Saif;Ahmed Saif

  • Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

    D. E. Gilham;W. Cairns;M. J. I. Paine;S. Modi

  • Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

    Gareth Lycett;L. A. McLaughlin;Hilary Ranson;Janet Hemingway

  • Engineering of a functional human NADH-dependent cytochrome P450 system.

    Olaf Döhr;Mark J. I. Paine;Thomas Friedberg;Gordon C. K. Roberts

Frequent Co-Authors

C. Roland Wolf
C. Roland Wolf University of Dundee
Janet Hemingway
Janet Hemingway Liverpool School of Tropical Medicine
Gordon C. K. Roberts
Gordon C. K. Roberts University of Leicester
John Vontas
John Vontas Foundation for Research and Technology Hellas
Michael J. Sutcliffe
Michael J. Sutcliffe University of Manchester
Hilary Ranson
Hilary Ranson Liverpool School of Tropical Medicine
Ana M. Moura-da-Silva
Ana M. Moura-da-Silva Instituto Butantan
Lu-Yun Lian
Lu-Yun Lian University of Liverpool
R.D.G. Theakston
R.D.G. Theakston Liverpool School of Tropical Medicine
Martin J. Donnelly
Martin J. Donnelly Liverpool School of Tropical Medicine

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry opens doors to a range of rewarding online degrees and career pathways. Students looking for flexible options can consider an online biology degree, which offers a fast-track route to understanding essential life sciences from anywhere.

For those interested in healthcare roles, registered nurse online programs make it possible to prepare for the NCLEX-RN licensure exam and pursue nursing without sacrificing job or family commitments.

A background in Biology also complements careers in wellness and nutrition. Consider pursuing an online nutritionist degree to become a registered dietitian or wellness coach, with hands-on components you can complete locally.

For those seeking leadership, the top cahme accredited mha programs can advance your skills in healthcare management. These accredited programs prepare students to oversee hospitals, clinics, and research organizations.

Each pathway offers online study flexibility while preparing graduates for high-demand roles in science, healthcare, and management.

Best Scientists Citing Mark J. I. Paine

Trending Scientists

Recently Published Articles