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Biology and Biochemistry

D-Index
49
Citations
8228
World Ranking
18056
National Ranking
3

Overview

Alexandra Rucavado is affiliated with the University of Costa Rica in Costa Rica. Their research primarily focuses on venomous animal envenomation and related studies within the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. This work intersects multiple specialized subfields such as Genetics, Virology, and Molecular Biology.

The scientist has contributed extensively to the understanding of venom actions and therapeutic responses, as reflected in publications appearing predominantly in the journal Toxicon, where they have published 13 papers. Other frequent publication venues include Toxins, Scientific Reports, Molecular Biology and Evolution, and TH Open.

Some of the recent papers by Alexandra Rucavado include:

  • "The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming" (2021, Toxins)
  • "A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor" (2020, Scientific Reports)
  • "Resistance of South American opossums to vWF-binding venom C-type lectins" (2020, Toxicon)
  • "Analysis of wound exudates reveals differences in the patterns of tissue damage and inflammation induced by the venoms of Daboia russelii and Bothrops asper in mice" (2020, Toxicon)
  • "Changes in basement membrane components in an experimental model of skeletal muscle degeneration and regeneration induced by snake venom and myotoxic phospholipase A2" (2021, Toxicon)

The main topics of their research include venomous animal envenomation and studies. Additional research topics involve rabies epidemiology and control, marine invertebrate physiology and ecology, amphibian and reptile biology, ion channel regulation and function, biochemical and structural characterization, and protease and inhibitor mechanisms.

  • Venomous Animal Envenomation and Studies
  • Rabies Epidemiology and Control
  • Marine Invertebrate Physiology and Ecology
  • Amphibian and Reptile Biology
  • Ion Channel Regulation and Function
  • Biochemical and Structural Characterization
  • Protease and Inhibitor Mechanisms

Alexandra Rucavado frequently collaborates with several coauthors in their research. Notable coauthors include José María Gutiérrez, Teresa Escalante, E. Camacho, Jay W. Fox, and Ivette Argüello.

  • José María Gutiérrez
  • Teresa Escalante
  • E. Camacho
  • Jay W. Fox
  • Ivette Argüello

The body of work by Alexandra Rucavado reflects consistent contributions to biochemical and molecular aspects of venom toxicology, including studies on tissue damage, inflammatory pathways, and potential inhibitors to improve therapeutic interventions for snakebite envenoming.

Best Publications

  • Snake venom metalloproteinases:Their role in the pathogenesis of local tissue damage

    José María Gutiérrez;Alexandra Rucavado

  • Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.

    José María Gutiérrez;Alexandra Rucavado;Teresa Escalante;Cecilia Díaz

  • Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection.

    Elías Barquero-Calvo;Esteban Chaves-Olarte;David S. Weiss;Caterina Guzmán-Verri

  • Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases

    Teresa Escalante;Alexandra Rucavado;Jay W. Fox;José María Gutiérrez

  • Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom

    José María Gutiérrez;Guillermo León;Gustavo Rojas;Bruno Lomonte

  • Experimental pathology of local tissue damage induced by Bothrops asper snake venom

    José María Gutiérrez;Alexandra Rucavado;Fernando Chaves;Cecilia Díaz

  • Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding

    José María Gutiérrez;Teresa Escalante;Alexandra Rucavado;Cristina Herrera

  • Trends in snakebite envenomation therapy: scientific, technological and public health considerations.

    Jose Maria Gutierrez;Bruno Lomonte;Guillermo Leon;Alexandra Rucavado

  • Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae).

    M.H Borges;A.M Soares;V.M Rodrigues;F Oliveira

  • Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.

    José María Gutiérrez;Teresa Escalante;Alexandra Rucavado

  • Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.

    José María Gutiérrez;Libia Sanz;José Escolano;Julián Fernández

  • Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.

    Alexandra Rucavado;Teresa Escalante;Aida Franceschi;Fernando Chaves

  • Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom

    Alexandra Rucavado;Bruno Lomonte;Michael Ovadia;Josée Marı́a Gutiérrez

  • Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.

    Leandra Watanabe;John D. Shannon;Richard H. Valente;Richard H. Valente;Alexandra Rucavado

  • Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.

    Alexandra Rucavado;Teresa Escalante;Catarina de Fátima Teixeira;Cristina Maria Fernandes

  • Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.

    Teresa Escalante;Aida Franceschi;Alexandra Rucavado;José Marı́a Gutiérrez

  • Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper

    Alexandra Rucavado;Javier Núñez;José María Gutiérrez

  • A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming.

    José María Gutiérrez;Teresa Escalante;Alexandra Rucavado;Cristina Herrera

  • Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.

    Gilbert D Lorı́a;Alexandra Rucavado;Aura S Kamiguti;R.David G Theakston

  • Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.

    Cristina Herrera;Teresa Escalante;Mathieu Benoit Voisin;Alexandra Rucavado

Frequent Co-Authors

José María Gutiérrez
José María Gutiérrez University of Costa Rica
Bruno Lomonte
Bruno Lomonte University of Costa Rica
Jay W. Fox
Jay W. Fox University of Virginia
Juan J. Calvete
Juan J. Calvete Spanish National Research Council
Yamileth Angulo
Yamileth Angulo University of Costa Rica
Libia Sanz
Libia Sanz Spanish National Research Council
Andreimar M. Soares
Andreimar M. Soares Oswaldo Cruz Foundation
Sussan Nourshargh
Sussan Nourshargh Queen Mary University of London
José R. Giglio
José R. Giglio Universidade de São Paulo
Edgardo Moreno
Edgardo Moreno National University of Costa Rica

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