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Chemistry

D-Index
41
Citations
6499
World Ranking
17756
National Ranking
969

Overview

Kirsty J. McLean is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also to medicine and pharmacology, toxicology, and pharmaceutics.

Their scholarly output highlights a focus on molecular biology and pharmacology, with subfields including infectious diseases and computational theory and mathematics. Key topics addressed in their work comprise pharmacogenetics and drug metabolism, tuberculosis research and epidemiology, and computational drug discovery methods. Additional areas of interest include steroid chemistry and biochemistry, microbial metabolic engineering and bioproduction, microbial natural products and biosynthesis, and plant biochemistry and biosynthesis.

Frequent coauthors collaborating with Kirsty J. McLean include Andrew W. Munro, Richard B. Tunnicliffe, Madeline E. Kavanagh, Colin Levy, and Chris Abell.

Their publications appear across a variety of scientific journals, notably:

  • International Journal of Molecular Sciences
  • ACS Catalysis
  • Chemistry - A European Journal
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry

Among their recent papers are:

  • A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism (2021, International Journal of Molecular Sciences)
  • Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin (2022, ACS Catalysis)
  • Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis (2023, Chemistry - A European Journal)
  • A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) (2022, European Journal of Medicinal Chemistry)
  • Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism (2025, Journal of Medicinal Chemistry)

Best Publications

  • P450 BM3: the very model of a modern flavocytochrome.

    Andrew W Munro;David G Leys;Kirsty J McLean;Ker R Marshall

  • Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily.

    Andrew W. Munro;Hazel M. Girvan;Kirsty J. McLean

  • Cytochrome P450--redox partner fusion enzymes.

    Andrew W. Munro;Hazel M. Girvan;Kirsty J. McLean

  • What makes a P450 tick

    Andrew W. Munro;Hazel M. Girvan;Amy E. Mason;Adrian J. Dunford

  • Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes

    Kirsty J. McLean;Ker R. Marshall;Alison Richmond;Iain S. Hunter

  • Structure and function of the cytochrome P450 peroxygenase enzymes.

    Andrew W. Munro;Kirsty J. McLean;Job L. Grant;Thomas M. Makris

  • Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

    James Belcher;Kirsty J. McLean;Sarah Matthews;Laura S. Woodward

  • Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450

    David G Leys;Christopher G. Mowat;Kirsty J McLean;Alison Richmond

  • Biodiversity of cytochrome P450 redox systems.

    K.J. McLean;M. Sabri;K.R. Marshall;R.J. Lawson

  • P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

    Carlos G. Acevedo-Rocha;Carlos G. Acevedo-Rocha;Charles G. Gamble;Richard Lonsdale;Richard Lonsdale;Richard Lonsdale;Aitao Li;Aitao Li;Aitao Li

  • Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv

    Kirsty J. McLean;Paul Carroll;D. Geraint Lewis;Adrian J. Dunford

  • Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

    Kirsty J. McLean;Marcus Hans;Ben Meijrink;Wibo B. Van Scheppingen

  • Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

    Harriet E. Seward;Anna Roujeinikova;Kirsty J. McLean;Andrew W. Munro

  • The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

    T.C Terwilliger;M.S Park;G.S Waldo;J Berendzen

  • Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142 EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

    Max D. Driscoll;Kirsty J. McLean;Colin Levy;Natalia Mast

  • The Structure of Mycobacterium tuberculosis CYP125 MOLECULAR BASIS FOR CHOLESTEROL BINDING IN A P450 NEEDED FOR HOST INFECTION

    Kirsty J. McLean;Pierre Lafite;Colin Levy;Myles R. Cheesman

  • Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.

    Kirsty J McLean;Myles R Cheesman;Stuart L Rivers;Alison Richmond

  • Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.

    A.J. Warman;O. Roitel;R. Neeli;H.M. Girvan

  • Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.

    Kirsty J. McLean;Ashley J. Warman;Harriet E. Seward;Ker R. Marshall

  • The TB structural genomics consortium: providing a structural foundation for drug discovery.

    Celia W. Goulding;Marcin Apostol;Daniel H. Anderson;Harindarpal S. Gill

  • Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.

    Kirsty J. McLean;Adrian J. Dunford;Rajasekhar Neeli;Max D. Driscoll

Frequent Co-Authors

Andrew W. Munro
Andrew W. Munro University of Manchester
N. Gehrels
N. Gehrels Goddard Space Flight Center
T. Sakamoto
T. Sakamoto Aoyama Gakuin University
David Leys
David Leys University of Manchester
Stephen E. J. Rigby
Stephen E. J. Rigby University of Manchester
Nigel S. Scrutton
Nigel S. Scrutton University of Manchester
Chris Abell
Chris Abell University of Cambridge
Martin J. Warren
Martin J. Warren University of Kent
Myles R. Cheesman
Myles R. Cheesman University of East Anglia
Andy Lawrence
Andy Lawrence University of Edinburgh

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