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Chemistry

D-Index
46
Citations
7868
World Ranking
16031
National Ranking
887

Biology and Biochemistry

D-Index
43
Citations
7448
World Ranking
19393
National Ranking
1501

Research.com Recognitions

  • 2019 - Bader Award, Royal Society of Chemistry (UK)

Overview

Jason Micklefield is affiliated with the University of Manchester in the United Kingdom. Their research spans primarily the fields of biochemistry, genetics, molecular biology, and chemistry, highlighting contributions across 34 publications in biochemistry, genetics and molecular biology, and 13 publications in chemistry.

The subfields of study most associated with Jason Micklefield include molecular biology, organic chemistry, biomedical engineering, pharmacology, and computational theory and mathematics. Their research topics cover enzyme catalysis and immobilization, chemical synthesis and analysis, microbial metabolic engineering and bioproduction, plant biochemistry and biosynthesis, catalytic C-H functionalization methods, carbohydrate chemistry and synthesis, and CRISPR and genetic engineering.

Some of the frequent publication venues where Jason Micklefield's work appears are:

  • Chemical Biology & Drug Design
  • Nature Communications
  • Current Opinion in Chemical Biology
  • Angewandte Chemie International Edition
  • Angewandte Chemie

Their notable recent papers include:

  • Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol (2020, Synthetic Biology)
  • Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers (2020, Metabolic Engineering)
  • Discovery, characterization and engineering of ligases for amide synthesis (2021, Nature)
  • Merging enzymes with chemocatalysis for amide bond synthesis (2022, Nature Communications)
  • New reaction pathways by integrating chemo- and biocatalysis (2022, Trends in Chemistry)

Jason Micklefield has collaborated frequently with fellow researchers such as Luis Bering, Sarah A. Shepherd, Mathangi Ramesh, Michela I. Simone, and Joseph Audie, evidencing productive partnerships in their fields of study.

In 2019, Jason Micklefield received the Bader Award from the Royal Society of Chemistry (UK), reflecting recognition within the scientific community.

Best Publications

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • Selective covalent protein immobilization: strategies and applications.

    Lu Shin Wong;Farid Khan;Jason Micklefield

  • S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

    Anna‐Winona Struck;Mark L. Thompson;Lu Shin Wong;Jason Micklefield

  • Development of Halogenase Enzymes for Use in Synthesis

    Jonathan Latham;Eileen Brandenburger;Sarah A. Shepherd;Binuraj R. K. Menon

  • Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

    Zohreh Hojati;Claire Milne;Barbara Harvey;Lyndsey Gordon

  • Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.

    Jason Micklefield

  • Mining and engineering natural-product biosynthetic pathways

    Barrie Wilkinson;Jason Micklefield

  • Recent advances in engineering nonribosomal peptide assembly lines

    Michael Winn;Joanna Fyans;Ying Zhuo;J Micklefield

  • An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Pablo Carbonell;Adrian J. Jervis;Christopher J. Robinson;Cunyu Yan

  • Reengineering orthogonally selective riboswitches

    Neil Dixon;John N. Duncan;Torsten Geerlings;Mark S. Dunstan

  • Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation

    Jonathan Latham;Jean-Marc Henry;Humera H. Sharif;Binuraj R. K. Menon

  • Direct Site-Selective Covalent Protein Immobilization Catalyzed by a Phosphopantetheinyl Transferase

    Lu Shin Wong;Jenny Thirlway;Jason Micklefield

  • Chemical modification of oligonucleotides for therapeutic, bioanalytical and other applications.

    Neil M. Bell;Jason Micklefield

  • NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin

    Lee Jon Ball;Catherine M. Goult;James A. Donarski;Jason Micklefield

  • Recent advances in methyltransferase biocatalysis.

    Matthew R Bennett;Sarah A Shepherd;Victoria A Cronin;Jason Micklefield

  • Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

    Sarah A. Shepherd;Chinnan Karthikeyan;Jonathan Latham;Anna-Winona Struck

  • Introduction of a Non‐Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

    Jenny Thirlway;Richard Lewis;Laura Nunns;Majid Al Nakeeb

  • Stereospecific Enzymatic Transformation of α-Ketoglutarate to (2S,3R)-3-Methyl Glutamate during Acidic Lipopeptide Biosynthesis

    Christoph Mahlert;Florian Kopp;Jenny Thirlway;Jason Micklefield

  • Biosynthesis of the (2S,3R)-3-Methyl Glutamate Residue of Nonribosomal Lipopeptides

    Claire Milne;Amanda Powell;John Jim;Majid Al Nakeeb

  • Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species.

    Christopher J Robinson;Helen A Vincent;Ming-Cheng Wu;Phillip T Lowe

  • Parallel Scanning Near-Field Photolithography: The Snomipede.

    Ehtsham Ul Haq;Zhuming Liu;Yuan Zhang;Shahrul A Alang Ahmad

Frequent Co-Authors

David Leys
David Leys University of Manchester
Barrie Wilkinson
Barrie Wilkinson John Innes Centre
Eriko Takano
Eriko Takano University of Manchester
Nicholas J. Turner
Nicholas J. Turner University of Manchester
Graham J. Leggett
Graham J. Leggett University of Sheffield
Rainer Breitling
Rainer Breitling University of Manchester
Royston Goodacre
Royston Goodacre University of Liverpool
Jean-Loup Faulon
Jean-Loup Faulon University of Paris-Saclay
Neil Swainston
Neil Swainston Epoch BioDesign
Nigel S. Scrutton
Nigel S. Scrutton University of Manchester

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