World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
8892
World Ranking
17217
National Ranking
7084

Overview

Margaret A. Phillips is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research contributions span multiple fields with a primary focus on biochemistry, genetics, and molecular biology, as well as medicine. Their work also encompasses several specialized subfields including molecular biology, biochemistry, public health, environmental and occupational health, organic chemistry, and infectious diseases.

The main topics covered in their research include:

  • Polyamine Metabolism and Applications
  • Biochemical and Molecular Research
  • Amino Acid Enzymes and Metabolism
  • Malaria Research and Control
  • HIV/AIDS Drug Development and Treatment
  • Enzyme Structure and Function
  • Computational Drug Discovery Methods

Phillips has published extensively in a range of scientific journals. The most frequent venues for their publications are:

  • Journal of Biological Chemistry (7 publications)
  • Journal of Medicinal Chemistry (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Proceedings of the National Academy of Sciences (2 publications)
  • ACS Infectious Diseases (2 publications)

The scientist often collaborates with several researchers across their projects. Frequent coauthors include:

  • Benoît Laleu (9 coauthored works)
  • Susan A. Charman (9 coauthored works)
  • Bin Li (9 coauthored works)
  • Anthony J. Michael (9 coauthored works)
  • Xiaoyi Deng (8 coauthored works)

Among their recent research papers are the following notable publications:

  • Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series, 2021, Journal of Medicinal Chemistry
  • Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria, 2020, Journal of Medicinal Chemistry
  • Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity, 2021, Chemical Science
  • Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis, 2021, Journal of Biological Chemistry
  • Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum, 2021, Journal of Medicinal Chemistry

Best Publications

  • Chemical genetics of Plasmodium falciparum.

    W. Armand Guiguemde;Anang A. Shelat;David Bouck;Sandra Duffy

  • Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

    Jose M. Coteron;María Marco;Jorge Esquivias;Xiaoyi Deng

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    Margaret A. Phillips;Julie Lotharius;Kennan Marsh;John White

  • Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

    Ramesh Gujjar;Alka Marwaha;Farah El Mazouni;John White

  • Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.

    Margaret A. Phillips;Pradipsinh K. Rathod

  • High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

    Jeffrey Baldwin;Carolyn H. Michnoff;Nicholas A. Malmquist;John White

  • Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum

    Margaret A. Phillips;Ramesh Gujjar;Nicholas A. Malmquist;John White

  • Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

    Ramesh Gujjar;Farah El Mazouni;Karen L. White;John White

  • An Alternative Polyamine Biosynthetic Pathway Is Widespread in Bacteria and Essential for Biofilm Formation in Vibrio cholerae

    Jeongmi Lee;Vanessa Sperandio;Douglas E. Frantz;Jamie Longgood

  • X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.

    Nick V. Grishin;Andrei L. Osterman;Harold B. Brooks;Harold B. Brooks;Margaret A. Phillips

  • Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.

    Jeffrey J Almrud;Marcos A Oliveira;Andrew D Kern;Nick V Grishin

  • State of the art in African trypanosome drug discovery.

    Robert T. Jacobs;Bakela Nare;Margaret A. Phillips

  • Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

    Michael L. Booker;Cecilia M. Bastos;Martin L. Kramer;Robert H. Barker

  • Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.

    Alejandro Llanos-Cuentas;Martin Casapia;Raúl Chuquiyauri;Juan Carlos Hinojosa

  • Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.

    Xiaoyi Deng;Ramesh Gujjar;Farah El Mazouni;Werner Kaminsky

  • Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

    James S McCarthy;Julie Lotharius;Thomas Rückle;Stephan Chalon

  • Alternative Spermidine Biosynthetic Route Is Critical for Growth of Campylobacter jejuni and Is the Dominant Polyamine Pathway in Human Gut Microbiota

    Colin C. Hanfrey;Bruce M. Pearson;Stuart Hazeldine;Jeongmi Lee

  • Acidic residues important for substrate binding and cofactor reactivity in eukaryotic ornithine decarboxylase identified by alanine scanning mutagenesis.

    Andrei L. Osterman;Lisa N. Kinch;Nick V. Grishin;Margaret A. Phillips

  • Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors

    Xiaoyi Deng;Sreekanth Kokkonda;Farah El Mazouni;John White

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    M. A. Phillips;J. Lotharius;K. Marsh;J. White

Frequent Co-Authors

Susan A. Charman
Susan A. Charman Monash University
John H. White
John H. White McGill University
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Anthony J. Michael
Anthony J. Michael The University of Texas Southwestern Medical Center
Lisa N. Kinch
Lisa N. Kinch The University of Texas Southwestern Medical Center
David A. Fidock
David A. Fidock Columbia University
Elizabeth J. Goldsmith
Elizabeth J. Goldsmith The University of Texas Southwestern Medical Center
Jef K. De Brabander
Jef K. De Brabander The University of Texas Southwestern Medical Center
R. Kiplin Guy
R. Kiplin Guy University of Kentucky

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry opens the door to a wide range of career opportunities, both in traditional lab settings and in rapidly-growing health information fields. Today, students can find flexible pathways through online programs that blend science with real-world application and career advancement.

If you’re interested in the business side of healthcare, consider exploring is medical billing and coding worth it to understand the pros and cons of this in-demand profession. Another option for those who enjoy organizing and analyzing health data is pursuing a health information management degree online, which can lead to roles managing patient records and healthcare systems.

For students passionate about wellness and nutrition, there are numerous online degrees in nutrition that focus on dietary science and public health. Additionally, those drawn to healthcare technology can look into ultrasound tech school online programs, which prepare graduates for critical diagnostic roles in the medical field.

Together, these online pathways offer flexibility, affordability, and practical skill-building, making them ideal complements or alternatives for students with a background or interest in Biology and Biochemistry.

Best Scientists Citing Margaret A. Phillips

Trending Scientists

Recently Published Articles