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Chemistry

D-Index
61
Citations
20027
World Ranking
9102
National Ranking
2570

Biology and Biochemistry

D-Index
61
Citations
20141
World Ranking
11129
National Ranking
4818

Overview

Elizabeth J. Goldsmith is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant portion of work dedicated to molecular biology as a subfield. Medicine is another main field of study represented in their publications.

Their research addresses several key topics, including:

  • Ion Transport and Channel Regulation
  • Metabolism, Diabetes, and Cancer
  • Protein Kinase Regulation and GTPase Signaling
  • Magnesium in Health and Disease
  • Melanoma and MAPK Pathways
  • Phagocytosis and Immune Regulation
  • Pancreatic function and diabetes

Elizabeth J. Goldsmith has contributed to various publication venues, often collaborating on papers appearing in:

  • Proceedings of the National Academy of Sciences
  • eLife
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Molecular Cancer Therapeutics

Recent publications include the following papers:

  • "WNK1 Enhances Migration and Invasion in Breast Cancer Models," 2021, Molecular Cancer Therapeutics
  • "WNKs are potassium-sensitive kinases," 2021, American Journal of Physiology-Cell Physiology
  • "Intracellular Ion Control of WNK Signaling," 2022, Annual Review of Physiology
  • "WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis," 2022, Proceedings of the National Academy of Sciences
  • "Limited inhibition of multiple nodes in a driver network blocks metastasis," 2021, eLife

Frequent collaborators in their work include:

  • Radha Akella
  • Haixia He
  • John M. Humphreys
  • Melanie H. Cobb
  • Ashari Rashmi Kannangara

Best Publications

  • How MAP kinases are regulated.

    Melanie H. Cobb;Elizabeth J. Goldsmith

  • Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

    Masato Kato;Tina W. Han;Shanhai Xie;Kevin Shi

  • Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

    Bertram J. Canagarajah;Andrei Khokhlatchev;Melanie H. Cobb;Elizabeth J. Goldsmith

  • Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.

    Andrei V. Khokhlatchev;Bertram Canagarajah;Julie Wilsbacher;Megan Robinson

  • Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.

    Faming Zhang;Arne Strand;David Robbins;Melanie H. Cobb

  • Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

    Sohini Mukherjee;Gladys Keitany;Yan Li;Yong Wang

  • Structural basis of latency in plasminogen activator inhibitor-1.

    James Mottonen;Arne Strand;Jindrich Symersky;Robert M. Sweet

  • WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

    Bing E. Xu;Jessie M. English;Jessie M. English;Julie L. Wilsbacher;Julie L. Wilsbacher;Steve Stippec

  • Structural basis of inhibitor selectivity in MAP kinases.

    Zhulun Wang;Bertram J Canagarajah;Jeffrey C Boehm;Skouki Kassisà

  • Modeling of the spatial structure of eukaryotic ornithine decarboxylases

    N. V. Grishin;M. A. Phillips;E. J. Goldsmith

  • Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

    Alexander T. Piala;Thomas M. Moon;Radha Akella;Haixia He

  • Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.

    Chung I. Chang;Bing E. Xu;Radha Akella;Melanie H. Cobb

  • Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

    Jose M. Coteron;María Marco;Jorge Esquivias;Xiaoyi Deng

  • A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

    Megan J. Robinson;Stephen A. Stippec;Elizabeth Goldsmith;Michael A. White

  • Structural changes in glycogen phosphorylase induced by phosphorylation.

    S. R. Sprang;K. R. Acharya;Elizabeth J Goldsmith;D. I. Stuart

  • The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

    Zhulun Wang;Paul C. Harkins;Richard J. Ulevitch;Jiahuai Han

  • Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

    Thomas Lee;Andrew N Hoofnagle;Yukihito Kabuyama;James Stroud

  • Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

    Rebecca J. Gum;Megan M. McLaughlin;Sanjay Kumar;Zhulun Wang

  • Serpin-resistant mutants of human tissue-type plasminogen activator.

    Edwin L. Madison;Elizabeth J. Goldsmith;Robert D. Gerard;Mary Jane H Gething

  • Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

    Xiaoshan Min;Byung Hoon Lee;Melanie H. Cobb;Elizabeth J. Goldsmith

Frequent Co-Authors

Melanie H. Cobb
Melanie H. Cobb The University of Texas Southwestern Medical Center
Stephen R. Sprang
Stephen R. Sprang University of Montana
Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Robert D. Gerard
Robert D. Gerard The University of Texas Southwestern Medical Center
Nick V. Grishin
Nick V. Grishin The University of Texas Southwestern Medical Center
Joseph Sambrook
Joseph Sambrook The University of Texas Southwestern Medical Center
Margaret A. Phillips
Margaret A. Phillips The University of Texas Southwestern Medical Center
Jiahuai Han
Jiahuai Han Xiamen University
Marsha Rich Rosner
Marsha Rich Rosner University of Chicago
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill

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