World's Best Scientists 2026 revealed!
JoAnne Stubbe

JoAnne Stubbe

D-Index & Metrics

Chemistry

D-Index
98
Citations
31935
World Ranking
1408
National Ranking
544

Biology and Biochemistry

D-Index
98
Citations
32413
World Ranking
1679
National Ranking
935

Research.com Recognitions

  • 2020 - Fellow of the American Chemical Society
  • 2020 - Priestley Medal, American Chemical Society (ACS)
  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2010 - Murray Goodman Memorial Prize, American Chemical Society (ACS)
  • 2010 - Welch Award in Chemistry, Robert A. Welch Foundation Harvard Medical School
  • 2009 - Nakanishi Prize, Chemical Society of Japan and the American Chemical Society.
  • 2008 - US President's National Medal of Science "For her ground-breaking experiments establishing the mechanisms of ribonucleotide reductases, polyester synthases, and natural product DNA cleavers  compelling demonstrations of the power of chemical investigations to solve problems in biology.", Presented by President Barack H. Obama in the East Room of the White House on October 7, 2009.
  • 2008 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For landmark work on the mechanisms and regulation of ribonucleotide reductases, a compelling demonstration of the power of chemical investigations to solve problems in biology.
  • 1998 - F.A. Cotton Medal for Excellence in Chemical Research, American Chemical Society (ACS)
  • 1992 - Member of the National Academy of Sciences
  • 1991 - Fellow of the American Academy of Arts and Sciences

Overview

JoAnne Stubbe is affiliated with MIT in the United States and has contributed extensively to the fields of Chemistry and Biochemistry, Genetics and Molecular Biology. Their research spans several subfields including Inorganic Chemistry, Molecular Biology, Oncology, Biophysics, and Materials Chemistry.

The scientist's work focuses on topics such as Metal-Catalyzed Oxygenation Mechanisms, Photosynthetic Processes and Mechanisms, Metal complexes synthesis and properties, Electron Spin Resonance Studies, Porphyrin and Phthalocyanine Chemistry, Metalloenzymes and iron-sulfur proteins, and Lanthanide and Transition Metal Complexes.

Frequent collaborators of JoAnne Stubbe include:

  • Daniel G. Nocera
  • Catherine L. Drennan
  • Gyunghoon Kang
  • Chang Cui
  • Marina Bennati

Publications by JoAnne Stubbe have appeared mainly in the following venues:

  • Journal of the American Chemical Society
  • Proceedings of the National Academy of Sciences
  • Biochemistry
  • Science
  • Chemical Science

Selected recent papers include:

  • Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex, 2020, Science
  • Radicals in Biology: Your Life Is in Their Hands, 2021, Journal of the American Chemical Society
  • 19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of E. coli Ribonucleotide Reductase, 2022, Journal of the American Chemical Society
  • Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase, 2020, Journal of the American Chemical Society
  • Detection of Water Molecules on the Radical Transfer Pathway of Ribonucleotide Reductase by 17O Electron-Nuclear Double Resonance Spectroscopy, 2021, Journal of the American Chemical Society

JoAnne Stubbe has received a number of awards and recognitions including:

  • Priestley Medal, American Chemical Society (ACS), 2020
  • Fellow of the American Chemical Society, 2020
  • Fellow of the American Association for the Advancement of Science (AAAS), 2014
  • Welch Award in Chemistry, Robert A. Welch Foundation, 2010
  • Murray Goodman Memorial Prize, American Chemical Society (ACS), 2010
  • Nakanishi Prize, Chemical Society of Japan and the American Chemical Society, 2009
  • US President's National Medal of Science, 2008
  • NAS Award in Chemical Sciences, National Academy of Sciences (US), 2008
  • F.A. Cotton Medal for Excellence in Chemical Research, American Chemical Society (ACS), 1998
  • Member of the National Academy of Sciences, 1992
  • Fellow of the American Academy of Arts and Sciences, 1991

Best Publications

  • Protein Radicals in Enzyme Catalysis.

    Jo Anne Stubbe;Wilfred Adrianus van der Donk

  • Mechanisms of bleomycin-induced DNA degradation

    JoAnne. Stubbe;John W. Kozarich

  • Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?

    JoAnne Stubbe;Daniel G Nocera;Cyril S Yee;Michelle C Y Chang

  • Bleomycins: towards better therapeutics

    Jingyang Chen;JoAnne Stubbe

  • Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism

    Luke Richard Thompson;Qinglu Zeng;Libusha Kelly;Katherine H. Huang

  • Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase.

    J. M. Bollinger;D. E. Edmondson;B. H. Huynh;J. Filley

  • Thiyl Radicals in Ribonucleotide Reductases

    Stuart Licht;Gary J. Gerfen;JoAnne Stubbe

  • Ribonucleotide reductases: amazing and confusing.

    J Stubbe

  • 2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase.

    C. H. Baker;J. Banzon;J. M. Bollinger;J. Stubbe

  • Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology

    Steven Y Reece;Justin M Hodgkiss;JoAnne Stubbe;Daniel G Nocera

  • Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase.

    Ellen C. Minnihan;Daniel G. Nocera;JoAnne Stubbe

  • Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster

    Ulrich Mühlenhoff;Sabine Molik;José R. Godoy;Marta A. Uzarska

  • Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity.

    T. U. Gerngross;K. D. Snell;O. P. Peoples;A. J. Sinskey

  • Binuclear Manganese(III) Complexes of Potential Biological Significance

    John E. Sheats;Roman S. Czernuszewicz;G. Charles Dismukes;Stephen J. Lippard

  • Reconsideration of X, the Diiron Intermediate Formed during Cofactor Assembly in E. coli Ribonucleotide Reductase

    Bradley E. Sturgeon;Doug Burdi;Shuxian Chen;Boi Hanh Huynh

  • BLEOMYCINS : A STRUCTURAL MODEL FOR SPECIFICITY, BINDING, AND DOUBLE STRAND CLEAVAGE

    JoAnne Stubbe;John W. Kozarich;Wei Wu;Dana E. Vanderwall

  • Protein radical involvement in biological catalysis

    Jo Anne Stubbe

  • A Model for the Role of Multiple Cysteine Residues Involved in Ribonucleotide Reduction: Amazing and Still Confusing

    S. S. Mao;T. P. Holler;G. X. Yu;J. M. Bollinger

  • PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo

    Sang Jun Sim;Kristi D. Snell;Scott A. Hogan;Jo Anne Stubbe

  • Ribonucleotide reductases: radical enzymes with suicidal tendencies

    Jo Anne Stubbe;Wilfred Adrianus van der Donk

Frequent Co-Authors

Daniel G. Nocera
Daniel G. Nocera Harvard University
John W. Kozarich
John W. Kozarich The University of Texas at Austin
Mohammad R. Seyedsayamdost
Mohammad R. Seyedsayamdost Princeton University
Marina Bennati
Marina Bennati Max Planck Society
Steven E. Ealick
Steven E. Ealick Cornell University
Dale E. Edmondson
Dale E. Edmondson Emory University
Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign

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