World's Best Scientists 2026 revealed!
Catherine L. Drennan

Catherine L. Drennan

D-Index & Metrics

Chemistry

D-Index
65
Citations
14132
World Ranking
7722
National Ranking
2258

Biology and Biochemistry

D-Index
66
Citations
14204
World Ranking
8743
National Ranking
3916

Research.com Recognitions

  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Fellow of Alfred P. Sloan Foundation

Overview

Catherine L. Drennan is affiliated with MIT in the United States and focuses their research primarily within the fields of biochemistry, genetics, and molecular biology. Their academic work includes a strong emphasis on molecular biology, renewable energy, sustainability and the environment, inorganic chemistry, materials chemistry, and oncology.

Their main areas of investigation cover several key topics, including:

  • Metal-Catalyzed Oxygenation Mechanisms
  • Metalloenzymes and iron-sulfur proteins
  • Photosynthetic Processes and Mechanisms
  • Metal complexes synthesis and properties
  • Enzyme Structure and Function
  • Porphyrin Metabolism and Disorders
  • CO2 Reduction Techniques and Catalysts

They have collaborated frequently with a number of coauthors, among whom are:

  • Mary C. Andorfer
  • Talya S. Levitz
  • Lindsey R. F. Backman
  • Gyunghoon Kang
  • Edward J. Brignole

Their publications have appeared prominently in several scientific venues, including:

  • The FASEB Journal
  • Journal of Biological Chemistry
  • Structural Dynamics
  • Journal of the American Chemical Society
  • Acta Crystallographica Section A Foundations and Advances

Notable recent papers authored or coauthored by Catherine L. Drennan include:

  • Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets, 2020, Annual Review of Biochemistry
  • Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex, 2020, Science
  • A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria, 2022, Nature Microbiology
  • Structural basis for non-radical catalysis by TsrM, a radical SAM methylase, 2021, Nature Chemical Biology
  • Cobalamin-Dependent Radical S-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions, 2022, ACS Bio & Med Chem Au

Awards received by Catherine L. Drennan include:

  • Fellow of the American Academy of Arts and Sciences, 2020
  • Fellow of Alfred P. Sloan Foundation, 2003

Best Publications

  • How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase

    Catherine Luschinsky Drennan;Sha Huang;James T. Drummond;Rowena G. Matthews

  • A Ni-Fe-Cu Center in a Bifunctional Carbon Monoxide Dehydrogenase/ Acetyl-CoA Synthase

    Tzanko I. Doukov;Tina M. Iverson;Javier Seravalli;Stephen W. Ragsdale

  • Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.

    Frederick Berkovitch;Yvain Nicolet;Jason T. Wan;Joseph T. Jarrett

  • Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis.

    Leah C. Blasiak;Frédéric H. Vaillancourt;Frédéric H. Vaillancourt;Christopher T. Walsh;Catherine L. Drennan

  • Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.

    Catherine L. Drennan;Jongyun Heo;Michael D. Sintchak;Eric Schreiter

  • Changing the Culture of Science Education at Research Universities

    W. A. Anderson;U. Banerjee;C. L. Drennan;S. C. R. Elgin

  • Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases.

    Ellen Yeh;Leah C. Blasiak;Alexander Koglin;Catherine L. Drennan

  • Structural insights into radical generation by the radical SAM superfamily.

    Jessica L. Vey;Catherine L. Drennan

  • THE CRYSTAL STRUCTURE OF CLASS II RIBONUCLEOTIDE REDUCTASE REVEALS HOW AN ALLOSTERICALLY REGULATED MONOMER MIMICS A DIMER

    Michael D. Sintchak;Gitrada Arjara;Brenda A. Kellogg;JoAnne Stubbe

  • Structural perspective on enzymatic halogenation.

    Leah C. Blasiak;Catherine L. Drennan

  • AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo

    James C Delaney;Lisa Smeester;Cintyu Wong;Lauren E Frick

  • Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme.

    Jessica L. Vey;Jian Yang;Meng Li;William E. Broderick

  • Crystal structure of the nickel-responsive transcription factor NikR.

    Eric R Schreiter;Michael D Sintchak;Yayi Guo;Peter T Chivers;Peter T Chivers

  • Ribbon–helix–helix transcription factors: variations on a theme

    Eric R Schreiter;Catherine L Drennan

  • Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.

    Brandon L Greene;Gyunghoon Kang;Chang Cui;Chang Cui;Marina Bennati;Marina Bennati

  • SPASM and Twitch Domains in S-Adenosylmethionine (SAM) Radical Enzymes

    Tsehai A. J. Grell;Peter J. Goldman;Catherine L. Drennan

  • Structural basis for gene regulation by a B12-dependent photoreceptor.

    Marco Jost;Jésus Fernández-Zapata;María Carmen Polanco;Juan Manuel Ortiz-Guerrero

  • Structure of human Fe–S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP–ISD11 interactions

    Seth A. Cory;Jonathan G. Van Vranken;Edward J. Brignole;Shachin Patra

  • NikR-operator complex structure and the mechanism of repressor activation by metal ions.

    Eric R. Schreiter;Sheila C. Wang;Deborah B. Zamble;Catherine L. Drennan

  • The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures

    Catherine L. Drennan;Tzanko I. Doukov;Stephen W. Ragsdale

  • Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.

    Danny Yun;Mishtu Dey;Luke J. Higgins;Luke J. Higgins;Feng Yan

Frequent Co-Authors

Stephen W. Ragsdale
Stephen W. Ragsdale University of Michigan–Ann Arbor
Christopher T. Walsh
Christopher T. Walsh Stanford University
Martha L. Ludwig
Martha L. Ludwig University of Michigan–Ann Arbor
Squire J. Booker
Squire J. Booker Pennsylvania State University
Rowena G. Matthews
Rowena G. Matthews University of Michigan–Ann Arbor
Hung-wen Liu
Hung-wen Liu The University of Texas at Austin
R. David Britt
R. David Britt University of California, Davis

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