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D-Index & Metrics

Chemistry

D-Index
53
Citations
9980
World Ranking
13092
National Ranking
964

Biology and Biochemistry

D-Index
53
Citations
10041
World Ranking
16171
National Ranking
1134

Overview

Felix Rohdich is affiliated with the Technical University of Munich in Germany and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, oncology, hematology, cellular and molecular neuroscience, and genetics.

The main topics of their work include:

  • Peptidase Inhibition and Analysis
  • Multiple Myeloma Research and Treatments
  • Ubiquitin and proteasome pathways
  • Neuropeptides and Animal Physiology
  • PI3K/AKT/mTOR signaling in cancer
  • Protein Degradation and Inhibitors
  • Melanoma and MAPK Pathways

Felix Rohdich has collaborated frequently with several co-authors, including:

  • Manja Friese-Hamim (7 publications)
  • Djordje Müsil (5 publications)
  • Christina Esdar (4 publications)
  • Floriane Lignet (4 publications)
  • Claude Gimmi (4 publications)

Their research outputs have appeared in multiple publication venues, notably:

  • Journal of Medicinal Chemistry (3 publications)
  • Molecular Cancer Therapeutics (2 publications)
  • Cancer Research Communications (1 publication)
  • CPT Pharmacometrics & Systems Pharmacology (1 publication)
  • Journal of Pharmacology and Experimental Therapeutics (1 publication)

Selected recent papers authored or co-authored by Felix Rohdich include:

  • "M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models," 2021, Molecular Cancer Therapeutics
  • "Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)," 2021, Journal of Medicinal Chemistry
  • "Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers," 2021, Journal of Medicinal Chemistry
  • "Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models," 2021, Journal of Medicinal Chemistry
  • "A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors," 2023, Cancer Research Communications

Best Publications

  • Biosynthesis of isoprenoids via the non-mevalonate pathway

    W. Eisenreich;A. Bacher;D. Arigoni;F. Rohdich

  • Deoxyxylulose phosphate pathway to terpenoids.

    Wolfgang Eisenreich;Felix Rohdich;Adelbert Bacher

  • Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein

    Felix Rohdich;Stefan Hecht;Katrin Gärtner;Petra Adam

  • Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.

    Felix Rohdich;Juraithip Wungsintaweekul;Monika Fellermeier;Silvia Sagner

  • Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.

    Stefan Herz;Juraithip Wungsintaweekul;Christoph A. Schuhr;Stefan Hecht

  • Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

    Holger Lüttgen;Felix Rohdich;Stefan Herz;Juraithip Wungsintaweekul

  • Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein

    Stefan Hecht;Wolfgang Eisenreich;Petra Adam;Sabine Amslinger

  • The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

    Felix Rohdich;Ferdinand Zepeck;Petra Adam;Stefan Hecht

  • The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.

    Felix Rohdich;Klaus Kis;Adelbert Bacher;Wolfgang Eisenreich

  • Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC) - Implications for the catalytic mechanism and anti-malaria drug development

    Stefan Steinbacher;Johannes Kaiser;Wolfgang Eisenreich;Robert Huber

  • Biosynthesis of terpenes: Studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase

    Petra Adam;Stefan Hecht;Wolfgang Eisenreich;Johannes Kaiser

  • Quantitative assessment of crosstalk between the two isoprenoid biosynthesis pathways in plants by NMR spectroscopy

    Christoph A. Schuhr;Tanja Radykewicz;Silvia Sagner;Christoph Latzel

  • IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis.

    Tobias Gräwert;Johannes Kaiser;Ferdinand Zepeck;Ralf Laupitz

  • Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.

    Felix Rohdich;Juraithip Wungsintaweekul;Wolfgang Eisenreich;Gerald Richter

  • Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study.

    Nicholas Schramek;Huahong Wang;Werner Römisch-Margl;Birgit Keil

  • Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli.

    Wael Ismail;Magdy El-Said Mohamed;Barry L. Wanner;Kirill A. Datsenko

  • Isoprenoid biosynthetic pathways as anti-infective drug targets.

    F. Rohdich;A. Bacher;W. Eisenreich

  • Enoate reductases of Clostridia. Cloning, sequencing, and expression.

    Felix Rohdich;Anja Wiese;Richard Feicht;Helmut Simon

  • Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato.

    Felix Rohdich;Juraithip Wungsintaweekul;Holger Lüttgen;Markus Fischer

  • A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

    Trevor Dale;Paul A Clarke;Christina Esdar;Dennis Waalboer

Frequent Co-Authors

Wolfgang Eisenreich
Wolfgang Eisenreich Technical University of Munich
Adelbert Bacher
Adelbert Bacher Technical University of Munich
Stefan Hecht
Stefan Hecht Humboldt-Universität zu Berlin
Robert Huber
Robert Huber University of Duisburg-Essen
William N. Hunter
William N. Hunter University of Dundee
Michael Groll
Michael Groll Technical University of Munich
Meinhart H. Zenk
Meinhart H. Zenk Ludwig-Maximilians-Universität München
Markus Fischer
Markus Fischer Universität Hamburg
Charles S. Bond
Charles S. Bond University of Western Australia

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