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Nobuhisa Iwata

Nobuhisa Iwata

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
19654
World Ranking
11136
National Ranking
764

Overview

Nobuhisa Iwata is affiliated with Nagasaki University in Japan and primarily conducts research in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Physiology, Neurology, Immunology, Cellular and Molecular Neuroscience, and Genetics.

The scientist's research encompasses a range of main topics such as:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Computational Drug Discovery Methods
  • Genetics and Neurodevelopmental Disorders
  • Galectins and Cancer Biology
  • Macrophage Migration Inhibitory Factor

Nobuhisa Iwata has contributed to several recent papers, including:

  • "Recent Advances in the Modeling of Alzheimer's Disease", 2022, Frontiers in Neuroscience
  • "Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein", 2020, Journal of Biological Chemistry
  • "The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain", 2024, Science Signaling
  • "Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice", 2020, npj Vaccines
  • "The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2", 2022, The Journal of Biochemistry

In their publishing record, the most frequent venues where work has appeared include:

  • The Journal of Biochemistry
  • Biological and Pharmaceutical Bulletin
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Neuroscience
  • Science Signaling

Nobuhisa Iwata collaborates regularly with several researchers, with the most frequent co-authors being:

  • Keiro Shirotani
  • Takaomi C. Saido
  • Kaori Watanabe
  • Naoto Watamura
  • Daisuke Hatta

Best Publications

  • Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

    Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  • Metabolic Regulation of Brain Aβ by Neprilysin

    Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki;Keiro Shirotani

  • Single App knock-in mouse models of Alzheimer's disease

    Takashi Saito;Yukio Matsuba;Naomi Mihira;Jiro Takano

  • Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.

    Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki;Kaori Watanabe

  • Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

    Takayuki Kondo;Masashi Asai;Masashi Asai;Kayoko Tsukita;Yumiko Kutoku

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

    Takashi Saito;Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki

  • 19F and 1H MRI detection of amyloid beta plaques in vivo.

    Makoto Higuchi;Nobuhisa Iwata;Yukio Matsuba;Kumi Sato

  • Aβ Secretion and Plaque Formation Depend on Autophagy

    Per Nilsson;Krishnapriya Loganathan;Misaki Sekiguchi;Yukio Matsuba

  • Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'

    Nobuhisa Iwata;Satoshi Tsubuki;Emi Hama;Yoshie Takaki

  • Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

    Jun Maeda;Bin Ji;Toshiaki Irie;Takami Tomiyama

  • Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.

    Keiro Shirotani;Satoshi Tsubuki;Nobuhisa Iwata;Yoshie Takaki

  • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain

    Nobuhisa Iwata;Hiroaki Mizukami;Keiro Shirotani;Yoshie Takaki

  • Potent amyloidogenicity and pathogenicity of Aβ43

    Takashi Saito;Takahiro Suemoto;Nathalie Brouwers;Kristel Sleegers

  • Metabolism of amyloid-β peptide and Alzheimer's disease

    Nobuhisa Iwata;Makoto Higuchi;Takaomi C. Saido

  • Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

    Chiho Hirata-Fukae;Hui Fang Li;Hyang Sook Hoe;Audrey J. Gray

  • The potential role of amyloid βin the pathogenesis of age-related macular degeneration

    Takeshi Yoshida;Kyoko Ohno-Matsui;Shizuko Ichinose;Tetsuji Sato

  • Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

    Nobuhisa Iwata;Yoshie Takaki;Shinjiro Fukami;Shinjiro Fukami;Satoshi Tsubuki

  • Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function *

    Shu Ming Huang;Akihiro Mouri;Hideko Kokubo;Hideko Kokubo;Ryuichi Nakajima

  • Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains EVIDENCE FROM CALPASTATIN MUTANT MICE

    Jiro Takano;Masanori Tomioka;Satoshi Tsubuki;Makoto Higuchi

Frequent Co-Authors

Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Takashi Saito
Takashi Saito Nagoya City University
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Toshiji Mukai
Toshiji Mukai Kobe University
Yukihiro Noda
Yukihiro Noda Meijo University
Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology
Shoichi Ishiura
Shoichi Ishiura University of Tokyo
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Shin-ichi Muramatsu
Shin-ichi Muramatsu Jichi Medical University

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