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Biology and Biochemistry

D-Index
52
Citations
11764
World Ranking
16556
National Ranking
163

Overview

Edgar Pick is affiliated with Tel Aviv University in Israel and has contributed to the fields of Immunology and Microbiology as well as Medicine. Their research spans subfields including Immunology, Neurology, Physiology, and Molecular Biology.

Their work addresses key themes in the study of immune function and cellular processes, focusing on topics such as:

  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Nitric Oxide and Endothelin Effects
  • Redox biology and oxidative stress
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Metabolomics and Mass Spectrometry Studies

Edgar Pick has coauthored publications with several researchers including Edna Bechor, Anat Zahavi, Yevgeny Berdichevsky, Maya Amichay, and Tanya Fradin.

Their recent scholarly articles appear primarily in the Journal of Leukocyte Biology, reflecting a focus on leukocyte-related biological mechanisms. Notable publications include:

  • p67phox binds to a newly identified site in Nox2 following the disengagement of an intramolecular bond-Canaan sighted?, 2020, Journal of Leukocyte Biology
  • The molecular basis of Rac-GTP action-promoting binding of p67phox to Nox2 by disengaging the β hairpin from downstream residues, 2021, Journal of Leukocyte Biology
  • p67phox-derived self-assembled peptides prevent Nox2 NADPH oxidase activation by an auto-inhibitory mechanism, 2020, Journal of Leukocyte Biology
  • In memoriam: Filippo Rossi (1926-2022), 2023, Journal of Leukocyte Biology

The scope of Edgar Pick's research contributions covers molecular interactions such as those involving the p67phox subunit and Nox2 enzyme complexes that are implicated in immune cell oxidative functions.

Best Publications

  • A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

    Edgar Pick;Yona Keisari

  • Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader

    Edgar Pick;Diane Mizel

  • Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.

    Arie Abo;Edgar Pick;Alan Hall;Nicholas Totty

  • Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages--induction by multiple nonphagocytic stimuli.

    Edgar Pick;Yona Keisari

  • Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

    Y Bromberg;E Pick

  • Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages.

    Yael Bromberg;Edgar Pick

  • Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader.

    Edgar Pick

  • Glucosylation and ADP Ribosylation of Rho Proteins: Effects on Nucleotide Binding, GTPase Activity, and Effector Coupling†

    Peter Sehr;Gili Joseph;Harald Genth;Ingo Just

  • Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds

    Valery Diatchuk;Ofra Lotan;Vasilij Koshkin;Peter Wikstroem

  • Biology of the Lymphokines

    Stanley Cohen;Edgar Pick;Joost J. Oppenheim

  • The biological activities of soluble lymphocyte products.

    E Pick;J L Turk

  • Unsaturated fatty acids as second messengers of superoxide generation by macrophages

    Yael Bromberg;Edgar Pick

  • The Cytosolic Component p47phox Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

    Vasilij Koshkin;Ofra Lotan;Edgar Pick

  • Targeting of Rac1 to the Phagocyte Membrane Is Sufficient for the Induction of NADPH Oxidase Assembly

    Yara Gorzalczany;Natalia Sigal;Michal Itan;Ofra Lotan

  • Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Absolute lipid dependence of the solubilized enzyme.

    S Shpungin;I Dotan;A Abo;E Pick

  • Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: A study based on mutagenesis of p67phox-Rac1 chimeras

    Rive Sarfstein;Yara Gorzalczany;Ariel Mizrahi;Yevgeny Berdichevsky

  • Interaction between 'sensitized lymphocytes' and antigen in vitro. I. The release of a skin reactive factor.

    E. Pick;J. Krejči;K. Čech;J. L. Turk

  • A rapid densitometric microassay for nitroblue tetrazolium reduction and application of the microassay to macrophages.

    Pick E;Charon J;Mizel D

  • The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559.

    S Knoller;S Shpungin;E Pick

  • Interaction between “sensitized lymphocytes” and antigen in vitro: II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors

    E. Pick;J. Brostoff;J. Krejci;J.L. Turk

Frequent Co-Authors

Anthony W. Segal
Anthony W. Segal University College London
Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
Dirk Roos
Dirk Roos University of Amsterdam
Mary C. Dinauer
Mary C. Dinauer Washington University in St. Louis
Nicholas F. Totty
Nicholas F. Totty Ludwig Cancer Research
Ingo Just
Ingo Just Hannover Medical School
Bryan Winchester
Bryan Winchester University College London
Alan Hall
Alan Hall Memorial Sloan Kettering Cancer Center
Howard R. Morris
Howard R. Morris Imperial College London
Anne Dell
Anne Dell Imperial College London

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