D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 57 Citations 13,486 116 World Ranking 9279 National Ranking 4123

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

His primary scientific interests are in Biochemistry, NADPH oxidase, Oxidase test, Superoxide and Molecular biology. In general Biochemistry, his work in NOX1, Enzyme activator and NAD+ kinase is often linked to NOx linking many areas of study. His study on NADPH oxidase is covered under Cell biology.

His Oxidase test research incorporates elements of Cytochrome, Flavoprotein and Cytosol. Thomas L. Leto combines subjects such as Chronic granulomatous disease, Nicotinamide adenine dinucleotide phosphate, Phagocyte, Sequence motif and SH3 domain with his study of Superoxide. His research in Molecular biology intersects with topics in Infectivity, Virus, RNase P and Ribonuclease.

His most cited work include:

  • Genetic, biochemical, and clinical features of chronic granulomatous disease (733 citations)
  • Identification of renox, an NAD(P)H oxidase in kidney. (702 citations)
  • Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense (404 citations)

What are the main themes of his work throughout his whole career to date?

Thomas L. Leto mainly investigates NADPH oxidase, Biochemistry, Molecular biology, Oxidase test and Cell biology. His studies in NADPH oxidase integrate themes in fields like Phagocyte, Superoxide and Chronic granulomatous disease. His NOX1 study in the realm of Superoxide connects with subjects such as Pseudomonas aeruginosa.

His Molecular biology research also works with subjects such as

  • Gene together with Apoptosis,
  • Locus that intertwine with fields like GPX1. His studies deal with areas such as Protein subunit, Transfection, Respiratory burst, SH3 domain and Cytochrome as well as Oxidase test. His Cell biology research includes elements of Cell and Cell migration.

He most often published in these fields:

  • NADPH oxidase (49.55%)
  • Biochemistry (37.84%)
  • Molecular biology (32.43%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cell biology (30.63%)
  • Molecular biology (32.43%)
  • NADPH oxidase (49.55%)

In recent papers he was focusing on the following fields of study:

Thomas L. Leto mostly deals with Cell biology, Molecular biology, NADPH oxidase, Cell migration and NOX4. His work deals with themes such as Cell and Missense mutation, which intersect with Cell biology. His work focuses on many connections between Molecular biology and other disciplines, such as Gene, that overlap with his field of interest in Isozyme.

His NADPH oxidase study results in a more complete grasp of Biochemistry. The Cell migration study combines topics in areas such as Wild type and NOX1. His biological study spans a wide range of topics, including TGF beta signaling pathway, Histone and Differential regulation.

Between 2013 and 2021, his most popular works were:

  • Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells (58 citations)
  • Release of Cystic Fibrosis Airway Inflammatory Markers from Pseudomonas aeruginosa–Stimulated Human Neutrophils Involves NADPH Oxidase-Dependent Extracellular DNA Trap Formation (52 citations)
  • NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases (31 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Thomas L. Leto mainly focuses on Superoxide, NADPH oxidase, Biochemistry, Cell biology and Molecular biology. His Superoxide study incorporates themes from Inflammation, Myeloperoxidase, Neutrophil extracellular traps and Kinase. Many of his research projects under NADPH oxidase are closely connected to Pseudomonas aeruginosa with Pseudomonas aeruginosa, tying the diverse disciplines of science together.

His study in NOX1, Reactive oxygen species and Macrophage are all subfields of Biochemistry. His Cell biology study integrates concerns from other disciplines, such as Wild type and Cell migration. The various areas that Thomas L. Leto examines in his Molecular biology study include RAC1, GTPase and GTP', Guanosine triphosphate.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Genetic, biochemical, and clinical features of chronic granulomatous disease

Brahm H. Segal;Thomas L. Leto;John I. Gallin;Harry L. Malech.
Medicine (2000)

1021 Citations

Identification of renox, an NAD(P)H oxidase in kidney.

Miklós Geiszt;Jeffrey B. Kopp;Péter Várnai;Thomas L. Leto.
Proceedings of the National Academy of Sciences of the United States of America (2000)

978 Citations

Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase

D Rotrosen;CL Yeung;TL Leto;HL Malech.
Science (1992)

528 Citations

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

Miklós Geiszt;Jassir Witta;Judit Baffi;Kristen Lekstrom.
The FASEB Journal (2003)

520 Citations

The Nox family of NAD(P)H oxidases: host defense and beyond.

Miklós Geiszt;Thomas L. Leto.
Journal of Biological Chemistry (2004)

503 Citations

Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

Thomas L. Leto;Karen J. Lomax;Bryan D. Volpp;Hiroyuki Nunoi.
Science (1990)

466 Citations

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.

Balázs Rada;Thomas L. Leto.
Contributions to microbiology (2008)

458 Citations

Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease

Karen J. Lomax;Thomas L. Leto;Hiroyuki Nunoi;John I. Gallin.
Science (1989)

440 Citations

Assembly of the phagocyte NADPH oxidase : binding of src homology 3 domains to proline-rich targets

T L Leto;A G Adams;I de Mendez.
Proceedings of the National Academy of Sciences of the United States of America (1994)

366 Citations

Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.

Thomas L. Leto;Stanislas Morand;Darrell Hurt;Takehiko Ueyama.
Antioxidants & Redox Signaling (2009)

336 Citations

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