His primary scientific interests are in Biochemistry, NADPH oxidase, Oxidase test, Superoxide and Molecular biology. In general Biochemistry, his work in NOX1, Enzyme activator and NAD+ kinase is often linked to NOx linking many areas of study. His study on NADPH oxidase is covered under Cell biology.
His Oxidase test research incorporates elements of Cytochrome, Flavoprotein and Cytosol. Thomas L. Leto combines subjects such as Chronic granulomatous disease, Nicotinamide adenine dinucleotide phosphate, Phagocyte, Sequence motif and SH3 domain with his study of Superoxide. His research in Molecular biology intersects with topics in Infectivity, Virus, RNase P and Ribonuclease.
Thomas L. Leto mainly investigates NADPH oxidase, Biochemistry, Molecular biology, Oxidase test and Cell biology. His studies in NADPH oxidase integrate themes in fields like Phagocyte, Superoxide and Chronic granulomatous disease. His NOX1 study in the realm of Superoxide connects with subjects such as Pseudomonas aeruginosa.
His Molecular biology research also works with subjects such as
Thomas L. Leto mostly deals with Cell biology, Molecular biology, NADPH oxidase, Cell migration and NOX4. His work deals with themes such as Cell and Missense mutation, which intersect with Cell biology. His work focuses on many connections between Molecular biology and other disciplines, such as Gene, that overlap with his field of interest in Isozyme.
His NADPH oxidase study results in a more complete grasp of Biochemistry. The Cell migration study combines topics in areas such as Wild type and NOX1. His biological study spans a wide range of topics, including TGF beta signaling pathway, Histone and Differential regulation.
Thomas L. Leto mainly focuses on Superoxide, NADPH oxidase, Biochemistry, Cell biology and Molecular biology. His Superoxide study incorporates themes from Inflammation, Myeloperoxidase, Neutrophil extracellular traps and Kinase. Many of his research projects under NADPH oxidase are closely connected to Pseudomonas aeruginosa with Pseudomonas aeruginosa, tying the diverse disciplines of science together.
His study in NOX1, Reactive oxygen species and Macrophage are all subfields of Biochemistry. His Cell biology study integrates concerns from other disciplines, such as Wild type and Cell migration. The various areas that Thomas L. Leto examines in his Molecular biology study include RAC1, GTPase and GTP', Guanosine triphosphate.
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Genetic, biochemical, and clinical features of chronic granulomatous disease
Brahm H. Segal;Thomas L. Leto;John I. Gallin;Harry L. Malech.
Identification of renox, an NAD(P)H oxidase in kidney.
Miklós Geiszt;Jeffrey B. Kopp;Péter Várnai;Thomas L. Leto.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase
D Rotrosen;CL Yeung;TL Leto;HL Malech.
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense
Miklós Geiszt;Jassir Witta;Judit Baffi;Kristen Lekstrom.
The FASEB Journal (2003)
The Nox family of NAD(P)H oxidases: host defense and beyond.
Miklós Geiszt;Thomas L. Leto.
Journal of Biological Chemistry (2004)
Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.
Thomas L. Leto;Karen J. Lomax;Bryan D. Volpp;Hiroyuki Nunoi.
Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.
Balázs Rada;Thomas L. Leto.
Contributions to microbiology (2008)
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease
Karen J. Lomax;Thomas L. Leto;Hiroyuki Nunoi;John I. Gallin.
Assembly of the phagocyte NADPH oxidase : binding of src homology 3 domains to proline-rich targets
T L Leto;A G Adams;I de Mendez.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.
Thomas L. Leto;Stanislas Morand;Darrell Hurt;Takehiko Ueyama.
Antioxidants & Redox Signaling (2009)
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