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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
16336
World Ranking
9088
National Ranking
4037

Overview

Thomas L. Leto is affiliated with the National Institutes of Health in the United States. Their research spans multiple interconnected fields of study including Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine.

Their work delves into key subfields such as Immunology, Molecular Biology, Genetics, Physiology, and Epidemiology. These subfields contribute to a broad understanding of immune system mechanisms and molecular interactions relevant to health and disease.

The primary topics addressed in their research focus on areas including:

  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Immunodeficiency and Autoimmune Disorders
  • Blood disorders and treatments
  • Erythrocyte Function and Pathophysiology
  • Immune Response and Inflammation
  • Immune cells in cancer
  • Fungal Infections and Studies

Thomas L. Leto has contributed to a variety of recent scientific papers, reflecting diverse aspects of immunology and related fields. Selected publications include:

  • "Immunogenetics associated with severe coccidioidomycosis," 2022, published in JCI Insight
  • "BTK drives neutrophil activation for sterilizing antifungal immunity," 2024, published in Journal of Clinical Investigation
  • "Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury," 2023, published in Redox Biology
  • "Clinical and functional spectrum of RAC2-related immunodeficiency," 2024, published in Blood
  • "A Novel RAC2 Variant Presenting as Severe Combined Immunodeficiency," 2020, published in Journal of Clinical Immunology

The venues where Thomas L. Leto frequently publishes include:

  • Blood
  • Antioxidants
  • Journal of Clinical Immunology
  • UNC Libraries
  • Clinical Immunology

The scientist's collaborations demonstrate significant partnerships with other researchers, including frequent co-authors such as Steven M. Holland, Ágnes Donkó, Amy P. Hsu, Douglas B. Kuhns, and Emilia Liana Falcone.

Best Publications

  • Genetic, biochemical, and clinical features of chronic granulomatous disease

    Brahm H. Segal;Thomas L. Leto;John I. Gallin;Harry L. Malech

  • Identification of renox, an NAD(P)H oxidase in kidney.

    Miklós Geiszt;Jeffrey B. Kopp;Péter Várnai;Thomas L. Leto

  • Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

    Miklós Geiszt;Jassir Witta;Judit Baffi;Kristen Lekstrom

  • The Nox family of NAD(P)H oxidases: host defense and beyond.

    Miklós Geiszt;Thomas L. Leto

  • Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.

    Balázs Rada;Thomas L. Leto

  • Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase

    Daniel Rotrosen;Choh L. Yeung;Thomas L. Leto;Harry L. Malech

  • Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

    Thomas L. Leto;Karen J. Lomax;Bryan D. Volpp;Hiroyuki Nunoi

  • Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease

    Karen J. Lomax;Thomas L. Leto;Hiroyuki Nunoi;John I. Gallin

  • Assembly of the phagocyte NADPH oxidase : binding of src homology 3 domains to proline-rich targets

    T L Leto;A G Adams;I de Mendez

  • Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.

    Thomas L. Leto;Stanislas Morand;Darrell Hurt;Takehiko Ueyama

  • Proteins Homologous to p47phox and p67phox Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

    Miklós Geiszt;Miklós Geiszt;Kristen Lekstrom;Jassir Witta;Thomas L. Leto

  • Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

    D Rotrosen;T L Leto

  • Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections

    Balázs Rada;Thomas L. Leto

  • Role of Nox family NADPH oxidases in host defense.

    Thomas L. Leto;Miklos Geiszt

  • Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.

    Raya Dana;Thomas L. Leto;Harry L. Malech;Rachel Levy

  • The complete cDNA and polypeptide sequences of human erythroid alpha-spectrin.

    K E Sahr;P Laurila;L Kotula;A L Scarpa

  • Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity

    Joseph B. Domachowske;Kimberly D. Dyer;Anthony G. Adams;Thomas L. Leto

  • Involvement of Rac1 in Activation of Multicomponent Nox1- and Nox3-Based NADPH Oxidases

    Takehiko Ueyama;Miklós Geiszt;Thomas L. Leto

  • PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox

    Jishu Shi;Christopher R. Ross;Thomas L. Leto;Frank Blecha

  • NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91phox in the Regulated Production of Superoxide by Phagocytes

    Miklós Geiszt;Kristen Lekstrom;Sebastian Brenner;Stephen M. Hewitt

Frequent Co-Authors

Harry L. Malech
Harry L. Malech National Institutes of Health
John I. Gallin
John I. Gallin National Institutes of Health
Rachel Levy
Rachel Levy Ben-Gurion University of the Negev
James H. Doroshow
James H. Doroshow National Institutes of Health
Steven M. Holland
Steven M. Holland National Institute of Allergy and Infectious Diseases
Amy P. Hsu
Amy P. Hsu National Institutes of Health
Steven M. Holland
Steven M. Holland University of Georgia
Philip M. Murphy
Philip M. Murphy National Institutes of Health
Douglas B. Kuhns
Douglas B. Kuhns National Institutes of Health
Ji-Liang Gao
Ji-Liang Gao National Institute of Allergy and Infectious Diseases

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