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D-Index & Metrics

Medicine

D-Index
108
Citations
47561
World Ranking
5959
National Ranking
3187

Overview

James H. Doroshow is affiliated with the National Institutes of Health in the United States and has a substantial portfolio of research within biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields, particularly molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and immunology.

The scientist's research topics focus largely on cancer genomics and diagnostics, epigenetics and DNA methylation, cancer cells and metastasis, sarcoma diagnosis and treatment, computational drug discovery methods, radiomics and machine learning in medical imaging, and cancer research and treatments.

James H. Doroshow has authored numerous papers, contributing to the following recent publications:

  • TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository, 2021, Journal of Translational Medicine
  • Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts, 2021, Nature Genetics
  • The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment, 2021, Cell
  • Converting tabular data into images for deep learning with convolutional neural networks, 2021, Scientific Reports
  • The NCI-MATCH trial: lessons for precision oncology, 2023, Nature Medicine

Doroshow collaborates frequently with a core group of researchers, including:

  • Yvonne A. Evrard
  • Alice P. Chen
  • Melinda G. Hollingshead
  • Ralph E. Parchment
  • Chris Karlovich

Their publications are frequently found in specialized journals such as:

  • Cancer Research
  • Journal of Clinical Oncology
  • Molecular Cancer Therapeutics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research

James H. Doroshow has also contributed to scholarly books, including a notable publication with Elsevier BV: "Abeloff's Clinical Oncology," published in 2020.

Best Publications

  • Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

    Junko Murai;Shar Yin N. Huang;Benu Brata Das;Amelie Renaud

  • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate by the advanced colorectal cancer meta-analysis project

    P. Piedbois;M. Buyse;Y. Rustum;D. Machover

  • Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites: ALTERATIONS PRODUCED BY DOXORUBICIN

    James H. Doroshow;Gershon Y. Locker;C. E. Myers

  • CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set

    William C. Reinhold;Margot Sunshine;Margot Sunshine;Hongfang Liu;Sudhir Varma

  • Effect of Anthracycline Antibiotics on Oxygen Radical Formation in Rat Heart

    James H. Doroshow

  • Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

    Junko Murai;Shar-yin N. Huang;Amèlie Renaud;Yiping Zhang

  • Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-Gi

    Fong-Fong Chu;J. H. Doroshow;R. S. Esworthy

  • Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study.

    Alan F. List;Kenneth J. Kopecky;Cheryl L. Willman;David R. Head

  • Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors

    Janneke E. Jaspers;Ariena Kersbergen;Ute Boon;Wendy Sol

  • Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.

    C G Leichman;T R Fleming;F M Muggia;C M Tangen

  • Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines.

    K A Margolin;A A Rayner;M J Hawkins;M B Atkins

  • Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies

    Shivaani Kummar;Robert Kinders;Martin E. Gutierrez;Larry Rubinstein

  • Anthracycline Antibiotic-stimulated Superoxide, Hydrogen Peroxide, and Hydroxyl Radical Production by NADH Dehydrogenase

    James H. Doroshow

  • Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.

    R. Steven Esworthy;Richard Aranda;Martín G. Martín;James H. Doroshow

  • Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes.

    Fong Fong Chu;R. Steven Esworthy;Peiguo G. Chu;Jeffrey A. Longmate

  • Analysis of Food and Drug Administration–Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

    Susan L. Holbeck;Jerry M. Collins;James H. Doroshow

  • Abeloff's Clinical Oncology

    John E. Niederhuber;James O. Armitage;James H. Doroshow;Michael B. Kastan

  • Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies.

    K G Blume;S J Forman;M R O'Donnell;J H Doroshow

  • Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

    J H Doroshow;G Y Locker;I Ifrim;C E Myers

  • Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

    Christophe E Redon;Asako J Nakamura;Yong-Wei Zhang;Jiuping Jay Ji

Frequent Co-Authors

Kim Margolin
Kim Margolin City Of Hope National Medical Center
George Somlo
George Somlo City Of Hope National Medical Center
Yves Pommier
Yves Pommier National Institutes of Health
David R. Gandara
David R. Gandara University of California, Davis
Jerry M. Collins
Jerry M. Collins National Institutes of Health
Heinz-Josef Lenz
Heinz-Josef Lenz University of Southern California
William C. Reinhold
William C. Reinhold National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Primo N. Lara
Primo N. Lara University of California, Davis
Stephen J. Forman
Stephen J. Forman City Of Hope National Medical Center

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