World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
14413
World Ranking
18560
National Ranking
355

Overview

Sven Rottenberg is affiliated with the University of Bern in Switzerland and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with particular focus on medicine. Their research spans multiple specialized subfields including molecular biology, oncology, pulmonary and respiratory medicine, genetics, and cancer research.

The primary topics of their work cover:

  • PARP inhibition in cancer therapy
  • DNA repair mechanisms
  • CRISPR and genetic engineering
  • Veterinary oncology research
  • Single-cell and spatial transcriptomics
  • Cancer genomics and diagnostics
  • Virus-based gene therapy research

Rottenberg has published in various notable venues. The most frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Molecular Cell, Cell Reports, and Journal of Comparative Pathology.

Several recent papers include:

  • The rediscovery of platinum-based cancer therapy (2020, Nature Reviews. Cancer)
  • Truncated FGFR2 is a clinically actionable oncogene in multiple cancers (2022, Nature)
  • Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps (2021, Molecular Cell)
  • Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics (2024, npj Precision Oncology)
  • International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations (2024, The Lancet Oncology)

Frequent co-authors who have collaborated extensively with Sven Rottenberg are:

  • Jos Jonkers
  • Paola Francica
  • Ewa Gogola
  • Kerstin Hahn
  • Martina Dettwiler

Best Publications

  • A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

    Norman Sachs;Joep de Ligt;Oded Kopper;Ewa Gogola

  • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

    Sven Rottenberg;Janneke E. Jaspers;Ariena Kersbergen;Eline van der Burg

  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

  • The rediscovery of platinum-based cancer therapy

    Sven Rottenberg;Carmen Disler;Paola Perego

  • REV7 counteracts DNA double-strand break resection and affects PARP inhibition

    Guotai Xu;J. Ross Chapman;Inger Brandsma;Jingsong Yuan

  • The Shieldin complex mediates 53BP1-dependent DNA repair

    Sylvie M. Noordermeer;Sylvie M. Noordermeer;Salomé Adam;Dheva Setiaputra;Marco Barazas

  • Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors

    Janneke E. Jaspers;Ariena Kersbergen;Ute Boon;Wendy Sol

  • PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

    Constantia Pantelidou;Olmo Sonzogni;Mateus De Oliveria Taveira;Anita K. Mehta

  • Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

    Baoxu Pang;Xiaohang Qiao;Lennert Janssen;Arno Velds

  • Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

    Sven Rottenberg;Anders O. H. Nygren;Marina Pajic;Fijs W. B. van Leeuwen

  • 53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

    Hind Ghezraoui;Catarina Oliveira;Jordan R. Becker;Kirstin Bilham

  • Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

    Ewa Gogola;Alexandra A. Duarte;Julian R. de Ruiter;Wouter W. Wiegant

  • EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

    Beatrice Rondinelli;Ewa Gogola;Hatice Yücel;Alexandra A. Duarte

  • BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

    Rinske Drost;Peter Bouwman;Sven Rottenberg;Ute Boon

  • How do real tumors become resistant to cisplatin

    Piet Borst;Sven Rottenberg;Jos Jonkers

  • Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

    Rosa Planells-Cases;Darius Lutter;Charlotte Guyader;Nora Merete Gerhards

  • Inhibition of apoptosis by intracellular protozoan parasites

    Volker T. Heussler;Peter Küenzi;Sven Rottenberg

  • CopywriteR: DNA copy number detection from off-target sequence data

    Thomas Kuilman;Arno Velds;Kristel Kemper;Marco Ranzani

  • Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

    Volker T. Heussler;Sven Rottenberg;Rebekka Schwab;Peter Küenzi

  • BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

    Alexandra A Duarte;Ewa Gogola;Norman Sachs;Marco Barazas

Frequent Co-Authors

Jos Jonkers
Jos Jonkers Antoni van Leeuwenhoek Hospital
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Marina Pajic
Marina Pajic Garvan Institute of Medical Research
Lodewyk F. A. Wessels
Lodewyk F. A. Wessels Antoni van Leeuwenhoek Hospital
Jirina Bartkova
Jirina Bartkova Karolinska Institute
Jos H. Beijnen
Jos H. Beijnen Utrecht University
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Sander R. Piersma
Sander R. Piersma VU University Medical Center
Connie R. Jimenez
Connie R. Jimenez Vrije Universiteit Amsterdam
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute

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