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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
26945
World Ranking
1944
National Ranking
37

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Jannie Borst is affiliated with Leiden University Medical Center in the Netherlands and conducts research primarily in the fields of immunology and microbiology, with a significant focus on medicine. Their work spans subfields such as immunology, oncology, molecular biology, cell biology, and pulmonary and respiratory medicine.

The research topics covered by Borst include:

  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Immune Response and Inflammation
  • Sphingolipid Metabolism and Signaling

Borst has authored papers published in a range of scientific journals, including multiple contributions to high-impact venues. Frequently published journals include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Reproductive Immunology
  • Cell Reports
  • Frontiers in Immunology
  • The Journal of Immunology

Some of the recent papers by Borst include:

  • Trial watch: Dendritic cell (DC)-based immunotherapy for cancer (2022, OncoImmunology)
  • Changes in Bcl-2 members after ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL (2020, Blood)
  • Opportunities for Small Molecules in Cancer Immunotherapy (2020, Trends in Immunology)
  • Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells (2021, Cell Reports)
  • Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses (2020, Cell Reports)

Collaborations have been a notable aspect of Borst's research, with frequent co-authors including Sander de Kivit, Ellen Schrama, Yanling Xiao, Mark Mensink, and Julia Busselaar. These co-authors have contributed to multiple joint publications, indicating consistent research partnerships.

Best Publications

  • CD4 + T cell help in cancer immunology and immunotherapy

    Jannie Borst;Tomasz Ahrends;Nikolina Bąbała;Cornelis J. M. Melief

  • CD27 is required for generation and long-term maintenance of T cell immunity

    J Hendriks;L A Gravestein;K Tesselaar;R A van Lier

  • Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

    P J Peters;J Borst;V Oorschot;M Fukuda

  • CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.

    Julie C Ribot;Ana deBarros;Ana deBarros;Dick John Pang;Joana F Neves;Joana F Neves

  • Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

    Riccardo Mezzadra;Chong Sun;Lucas T. Jae;Raquel Gomez-Eerland

  • Ceramide: second messenger or modulator of membrane structure and dynamics?

    Wim J van Blitterswijk;Arnold H van der Luit;Robert Jan Veldman;Marcel Verheij

  • A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.

    Jannie Borst;René J. van de Griend;Johan W. van Oostveen;Siew-Lan Ang

  • CD27 and CD70 in T cell and B cell activation.

    Jannie Borst;Jenny Hendriks;Yanling Xiao

  • CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool

    Jenny Hendriks;Yanling Xiao;Jannie Borst

  • The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

    D. Camerini;G. Walz;W. A. M. Loenen;J. Borst

  • Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.

    Ramon Arens;Kiki Tesselaar;Paul A Baars;Gijs M.W van Schijndel

  • CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

    Tomasz Ahrends;Aldo Spanjaard;Bas Pilzecker;Nikolina Bąbała

  • Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen.

    R. A. W. Van Lier;J. Borst;T. M. Vroom;H. Klein

  • Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.

    Kiki Tesselaar;Ramon Arens;Gijs M.W. van Schijndel;Paul A. Baars

  • Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

    H. Spits;J. Borst;W. Tax;P. J. A. Capel

  • Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes.

    Peter J. Peters;Hans J. Geuze;Hans A. Der Van Donk;Jan W. Slot

  • Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex

    Peter van den Elsen;Beth-Ann Shepley;Jannie Borst;John E. Coligan

  • During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8(+) memory T cells and their capacity for secondary expansion

    Jenny Hendriks;Yanling Xiao;John W A Rossen;Koenraad F van der Sluijs

  • c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.

    Annemieke A. de Melker;Gerda van der Horst;Jero Calafat;Hans Jansen

  • Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion.

    Y van Kooyk;P Weder;F Hogervorst;A J Verhoeven

Frequent Co-Authors

Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
Stephen W.G. Tait
Stephen W.G. Tait University of Glasgow
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
J E de Vries
J E de Vries AIMM Therapeutics (Netherlands)
Hideo Yagita
Hideo Yagita Juntendo University
René A. W. van Lier
René A. W. van Lier University of Amsterdam
Wim J. van Blitterswijk
Wim J. van Blitterswijk Antoni van Leeuwenhoek Hospital
Ramon Arens
Ramon Arens Leiden University Medical Center
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Hergen Spits
Hergen Spits University of Amsterdam

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