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Immunology

D-Index
62
Citations
12272
World Ranking
3156
National Ranking
122

Overview

Ramon Arens is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of Immunology and Microbiology, with significant contributions to Medicine. The scientist's work focuses on several key subfields, including Immunology, Oncology, Molecular Biology, Epidemiology, and Infectious Diseases.

Their main research topics encompass immune cell function and interaction, immunotherapy and immune responses, cancer immunotherapy and biomarkers, CAR-T cell therapy research, T-cell and B-cell immunology, cytomegalovirus and herpesvirus research, and the role of immune cells in cancer.

Ramon Arens has contributed to multiple scientific publications, with some recent notable papers including:

  • "Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses" (2020) published in Nature Immunology
  • "Uncoupling DNA damage from chromatin damage to detoxify doxorubicin" (2020) published in Proceedings of the National Academy of Sciences
  • "Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model" (2022) published in Gut
  • "Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention" (2020) published in Toxicology Reports
  • "Cytomegalovirus subverts macrophage identity" (2021) published in Cell

Frequent co-authors include Suzanne van Duikeren, Ferry Ossendorp, Iris N. Pardieck, Tetje C. van der Sluis, and Esmé T.I. van der Gracht. Their collaborative work reflects ongoing research partnerships within the fields of Immunology and Oncology.

Ramon Arens frequently publishes in specialized journals such as the Journal for ImmunoTherapy of Cancer, bioRxiv (Cold Spring Harbor Laboratory preprints), Frontiers in Immunology, Nature Immunology, and Nature Communications.

Best Publications

  • Therapeutic cancer vaccines

    Cornelis J.M. Melief;Thorbald van Hall;Ramon Arens;Ferry Ossendorp

  • Vaccines for established cancer: overcoming the challenges posed by immune evasion.

    Sjoerd H. van der Burg;Ramon Arens;Ferry Ossendorp;Thorbald van Hall

  • Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.

    Ramon Arens;Kiki Tesselaar;Paul A Baars;Gijs M.W van Schijndel

  • Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.

    Kiki Tesselaar;Ramon Arens;Gijs M.W. van Schijndel;Paul A. Baars

  • Autocrine IL-2 is required for secondary population expansion of CD8 + memory T cells

    Sonia Feau;Ramon Arens;Ramon Arens;Susan Togher;Stephen P Schoenberger

  • Plasticity in programming of effector and memory CD8+ T-cell formation

    Ramon Arens;Stephen P. Schoenberger

  • In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

    Stephan Halle;Kirsten Anja Keyser;Felix Rolf Stahl;Andreas Busche

  • Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo

    Kiki Tesselaar;Yanling Xiao;Ramon Arens;Gijs M. W. van Schijndel

  • The activation of the adaptive immune system: Cross-talk between antigen-presenting cells, T cells and B cells

    Joke M.M. den Haan;Ramon Arens;Menno C. van Zelm

  • Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses.

    Marij J. Welters;Tetje C. van der Sluis;Hélène van Meir;Nikki M. Loof

  • Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells.

    Cheryl H. Rozanski;Ramon Arens;Louise M. Carlson;Jayakumar Nair

  • Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

    Marieke F. Fransen;Tetje C. van der Sluis;Ferry Ossendorp;Ramon Arens

  • Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation

    Ramon Arens;Koen Schepers;Martijn A. Nolte;Michiel F. van Oosterwijk

  • Local Activation of CD8 T Cells and Systemic Tumor Eradication without Toxicity via Slow Release and Local Delivery of Agonistic CD40 Antibody

    Marieke F. Fransen;Marjolein Sluijter;Hans Morreau;Ramon Arens

  • Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient

    Jeroen W. J. van Heijst;Carmen Gerlach;Erwin Swart;Daoud Sie

  • New advances in CMV and immunosenescence.

    Paolo Sansoni;Rosanna Vescovini;Francesco F. Fagnoni;Arne Akbar

  • Signaling through CD70 regulates B cell activation and IgG production

    Ramon Arens;Martijn A. Nolte;Kiki Tesselaar;Bianca Heemskerk

  • CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.

    Michiel F. van Oosterwijk;Hedi Juwana;Ramon Arens;Kiki Tesselaar

  • Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses.

    Felix M. Behr;Loreto Parga-Vidal;Natasja A. M. Kragten;Teunis J. P. van Dam

  • Memory T cell inflation: understanding cause and effect

    Geraldine A. O’Hara;Suzanne P.M. Welten;Paul Klenerman;Ramon Arens

  • Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

    Xiaohang Qiao;Sabina Y. van der Zanden;Dennis P.A. Wander;Daniel M. Borràs

  • Sustained Antibody Responses Depend on CD28 Function in Bone Marrow Resident Plasma Cells

    Cheryl H Rozanski;Lindzy F Dodson;Ramon Arens;Louise M Carlson

Frequent Co-Authors

Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
René A. W. van Lier
René A. W. van Lier University of Amsterdam
Stephen P. Schoenberger
Stephen P. Schoenberger La Jolla Institute For Allergy & Immunology
Thorbald van Hall
Thorbald van Hall Leiden University Medical Center
Chris A. Benedict
Chris A. Benedict La Jolla Institute For Allergy & Immunology
Paul Klenerman
Paul Klenerman University of Oxford
Paul H.A. Quax
Paul H.A. Quax Leiden University Medical Center
Jannie Borst
Jannie Borst Leiden University Medical Center

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