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William M. Nauseef

William M. Nauseef

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
26435
World Ranking
2965
National Ranking
1517

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

William M. Nauseef is a researcher affiliated with the University of Iowa in the United States. Their work primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology, with specific focus on immunology, molecular biology, pulmonary and respiratory medicine, microbiology, and biological psychiatry as subfields of study.

Their research topics include neutrophil function, myeloperoxidase and oxidative mechanisms, immune response and inflammation, cystic fibrosis research advances, bacterial biofilms and quorum sensing, immune cells in cancer, tryptophan and brain disorders, and neonatal respiratory health research.

Recent papers authored or co-authored by William M. Nauseef include:

  • Human neutrophils ≠ murine neutrophils: Does it matter? (2022) published in Immunological Reviews
  • Neutrophil dysfunction in the pathogenesis of cystic fibrosis (2022) published in Blood
  • Cathepsin G Degrades Staphylococcus aureus Biofilms (2020) published in The Journal of Infectious Diseases
  • Neutrophil-derived extracellular vesicles modulate the phenotype of naïve human neutrophils (2021) published in Journal of Leukocyte Biology
  • HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages (2023) published in Proceedings of the National Academy of Sciences

Frequent co-authors in their research include Guoshun Wang, Alexander R. Horswill, Scott Jennings, Dianne Wellems, and Kevin G. Leidal. Publication venues where their work regularly appears include the Journal of Leukocyte Biology, Immunological Reviews, Blood, Proceedings of the National Academy of Sciences, and The Journal of Infectious Diseases.

Nauseef's research addresses fundamental mechanisms of neutrophil biology and their role in disease contexts such as cystic fibrosis and bacterial infections. Their work on oxidative mechanisms and immune cell phenotypes contributes to understanding immune system functions at the molecular and cellular levels.

William M. Nauseef is a member of the Association of American Physicians.

Best Publications

  • The neutrophil NADPH oxidase

    B.M. Babior;J.D. Lambeth;W. Nauseef

  • Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

    Shankar S. Iyer;Qiong He;John R. Janczy;Eric I. Elliott

  • Neutrophils at work

    William M Nauseef;Niels Borregaard

  • How human neutrophils kill and degrade microbes: an integrated view.

    William M. Nauseef

  • Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

    Jason P. Eiserich;Stephan Baldus;Marie Luise Brennan;Wenxin Ma

  • Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.

    Kathleen D. Metzler;Tobias A. Fuchs;William M. Nauseef;Dominique Reumaux

  • Myeloperoxidase: a front-line defender against phagocytosed microorganisms

    Seymour J. Klebanoff;Anthony J. Kettle;Henry Rosen;Christine C. Winterbourn

  • Assembly of the phagocyte NADPH oxidase

    William M. Nauseef;William M. Nauseef

  • Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease

    Bryan D. Volpp;William M. Nauseef;Robert A. Clark

  • Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

    Robert A. Clark;Bryan D. Volpp;Kevin G. Leidal;William M. Nauseef

  • Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

    Thomas L. Leto;Karen J. Lomax;Bryan D. Volpp;Hiroyuki Nunoi

  • A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

    Juan D. Matute;Andres A. Arias;Nicola A. M. Wright;Iwona Wrobel

  • Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

    William M. Nauseef;Bryan D. Volpp;Sally McCormick;Kevin G. Leidal

  • Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

    Paul G. Heyworth;John T. Curnutte;William M. Nauseef;Bryan D. Volpp

  • Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

    Bryan D. Volpp;William M. Nauseef;John E. Donelson;David R. Moser

  • NEUTROPHILS EXPOSED TO BACTERIAL LIPOPOLYSACCHARIDE UPREGULATE NADPH OXIDASE ASSEMBLY

    F R DeLeo;J Renee;S McCormick;M Nakamura

  • NADPH Oxidase Activation and Assembly During Phagocytosis

    Frank R. DeLeo;Lee-Ann H. Allen;Michael Apicella;William M. Nauseef

  • Biological roles for the NOX family NADPH oxidases.

    William M. Nauseef

  • Calreticulin Functions as a Molecular Chaperone in the Biosynthesis of Myeloperoxidase

    William M. Nauseef;Sally J. McCormick;Robert A. Clark

  • Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

    Robert A. Clark;Harry L. Malech;John I. Gallin;Hiroyuki Nunoi

Frequent Co-Authors

Robert A. Clark
Robert A. Clark The University of Texas Health Science Center at San Antonio
Frank R. DeLeo
Frank R. DeLeo National Institute of Allergy and Infectious Diseases
Alexander R. Horswill
Alexander R. Horswill University of Colorado Anschutz Medical Campus
Jerrold Weiss
Jerrold Weiss University of Iowa
Mary C. Dinauer
Mary C. Dinauer Washington University in St. Louis
Thomas S. Griffith
Thomas S. Griffith University of Minnesota
Lee-Ann H. Allen
Lee-Ann H. Allen University of Iowa
Algirdas J. Jesaitis
Algirdas J. Jesaitis Montana State University
Michael A. Apicella
Michael A. Apicella University of Iowa
Scott D. Kobayashi
Scott D. Kobayashi National Institutes of Health

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