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Molecular Biology

D-Index
54
Citations
9181
World Ranking
2334
National Ranking
1153

Overview

Nicholas H. Heintz is affiliated with the University of Vermont in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with specific focus on Molecular Biology and Biochemistry subfields.

The research topics that Heintz addresses include:

  • Redox biology and oxidative stress
  • Glutathione Transferases and Polymorphisms
  • Sulfur Compounds in Biology

Heintz's recent publications feature studies investigating mitochondrial antioxidant systems and their biochemical characteristics. Notable papers include:

  • "Unique Cellular and Biochemical Features of Human Mitochondrial Peroxiredoxin 3 Establish the Molecular Basis for Its Specific Reaction with Thiostrepton" (2021), published in Antioxidants
  • "Abstract B041: Mitochondrial antioxidant peroxiredoxin 3 is a tractable therapeutic target in mesothelioma" (2025), published in Molecular Cancer Therapeutics

These publications reflect work on mitochondrial peroxiredoxin 3, a key protein involved in cellular redox processes and antioxidant defense, as well as its implications in therapeutic contexts such as cancer treatment.

Frequent co-authors collaborating with Heintz include:

  • Terri Messier
  • Alexis Saaman
  • Brian Cunniff
  • Kimberly Nelson
  • Stephanie Milczarek

These collaborations are linked to research efforts in related biochemical and molecular biology topics, contributing to the collective understanding of antioxidant mechanisms and molecular therapeutics.

Heintz publishes regularly in journals that center on biochemical and molecular biology research. Frequent publication venues comprise:

  • Antioxidants
  • Molecular Cancer Therapeutics

Best Publications

  • Redox-based regulation of signal transduction : Principles, pitfalls, and promises

    Yvonne M.W. Janssen-Heininger;Brooke T. Mossman;Nicholas H. Heintz;Henry J. Forman

  • Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta.

    Niki L. Reynaert;Albert van der Vliet;Amy S. Guala;Toby McGovern

  • Differential regulation of antioxidant enzymes in response to oxidants.

    S. Shull;N.H. Heintz;M. Periasamy;M. Manohar

  • The cell cycle is a redox cycle: linking phase-specific targets to cell fate.

    William C. Burhans;Nicholas H. Heintz

  • Identification of an origin of bidirectional DNA replication in mammalian chromosomes

    William C. Burhans;Lyubomir T. Vassilev;Mark S. Caddle;Nicholas H. Heintz

  • Persistent induction of c-fos and c-jun expression by asbestos.

    Nicholas H. Heintz;Yvonne M. Janssen;Brooke T. Mossman

  • An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments

    Nicholas H. Heintz;Joyce L. Hamlin

  • mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

    Y C Chang;Y S Lee;T Tejima;K Tanaka

  • Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways.

    Nicholas H. Heintz;Yvonne M. W. Janssen-Heininger;Brooke T. Mossman

  • AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion.

    Brian Cunniff;Andrew J. McKenzie;Nicholas H. Heintz;Alan K. Howe

  • Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene

    J D Milbrandt;N H Heintz;W C White;S M Rothman

  • Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes.

    Richard J. Albertini;J. Patrick O'Neill;Janice A. Nicklas;Nicholas H. Heintz

  • Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

    Junji Magae;Chin-Lee Wu;Sharon Illenye;Ed Harlow

  • Induction of c-fos and c-jun Proto-oncogene Expression by Asbestos Is Ameliorated by N-Acetyl-l-Cysteine in Mesothelial Cells

    Yvonne M. W. Janssen;Nicholas H. Heintz;Brooke T. Mossman

  • Intramolecular DNA triplexes, bent DNA and DNA unwinding elements in the initiation region of an amplified dihydrofolate reductase replicon

    Mark S. Caddle;Richard H. Lussier;Nicholas H. Heintz

  • Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery

    Timothy J. Phalen;Kelly Weirather;Paula B. Deming;Vikas Anathy

  • Redox Regulation of Cell-Cycle Re-entry: Cyclin D1 as a Primary Target for the Mitogenic Effects of Reactive Oxygen and Nitrogen Species

    Peter M. Burch;Nicholas H. Heintz

  • Redox-Dependent Expression of Cyclin D1 and Cell Proliferation by Nox1 in Mouse Lung Epithelial Cells

    Priya Ranjan;Vikas Anathy;Peter M. Burch;Kelly Weirather

  • Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain

    William C. Burhans;Jane E. Selegue;Nicholas H. Heintz

  • INDUCTION OF C-FOS AND C-JUN PROTO-ONCOGENES IN TARGET CELLS OF THE LUNG AND PLEURA BY CARCINOGENIC FIBERS

    Yvonne M. W. Janssen;Nicholas H. Heintz;Joanne R Marsh;Paul J. A. Borm

Frequent Co-Authors

Yvonne M. W. Janssen-Heininger
Yvonne M. W. Janssen-Heininger University of Vermont
Albert van der Vliet
Albert van der Vliet University of Vermont
Harvey I. Pass
Harvey I. Pass New York University
Douglas J. Taatjes
Douglas J. Taatjes University of Vermont
Jack L. Arbiser
Jack L. Arbiser Emory University
Youji Mitsui
Youji Mitsui Tokushima Bunri University
Nathaniel Heintz
Nathaniel Heintz Rockefeller University
Joyce L. Hamlin
Joyce L. Hamlin University of Virginia
Joseph R. Testa
Joseph R. Testa Fox Chase Cancer Center
Susan S. Wallace
Susan S. Wallace University of Vermont

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