His primary areas of investigation include Biochemistry, Cysteine, Peroxiredoxin, Sulfenic acid and Signal transduction. His Redox research extends to the thematically linked field of Biochemistry. His Cysteine research integrates issues from Thiol, Peroxidase, Catalytic cycle, Peptide sequence and Stereochemistry.
Leslie B. Poole has researched Peroxiredoxin in several fields, including Thioredoxin reductase, Oxidoreductase, Enzyme kinetics and Active site. His studies examine the connections between Signal transduction and genetics, as well as such issues in Cysteine metabolism, with regards to Kinase, Intracellular, Second messenger system and Dephosphorylation. In his study, which falls under the umbrella issue of Peroxiredoxin III, Sulfiredoxin is strongly linked to Peroxiredoxin-4.
His primary scientific interests are in Biochemistry, Cysteine, Peroxiredoxin, Sulfenic acid and Peroxidase. His research on Biochemistry often connects related topics like Redox. The various areas that Leslie B. Poole examines in his Cysteine study include Oxidative damage, Thiol, Catalytic cycle, Stereochemistry and Protein structure.
Leslie B. Poole interconnects Active site, Peptide sequence, Cell biology, Thioredoxin and Peroxide in the investigation of issues within Peroxiredoxin. The Sulfenic acid study combines topics in areas such as Combinatorial chemistry, Reagent, Salt and Dimedone. Leslie B. Poole focuses mostly in the field of Peroxidase, narrowing it down to topics relating to Mutant and, in certain cases, Streptococcus mutans.
His main research concerns Biochemistry, Cell biology, Peroxiredoxin, Cysteine and Redox. In his research, Dithiol is intimately related to Stereochemistry, which falls under the overarching field of Biochemistry. Leslie B. Poole has included themes like Oxidative stress and Chondrocyte in his Cell biology study.
His Peroxiredoxin study combines topics in areas such as Mitogen-activated protein kinase and Xanthomonas campestris. His research in Cysteine is mostly focused on Sulfenic acid. His Peroxide research includes themes of Catalytic cycle and Hydrogen peroxide.
Leslie B. Poole mostly deals with Biochemistry, Peroxiredoxin, Cysteine, Active site and Redox. His Peroxiredoxin research integrates issues from Oxidative stress, Cell signaling, Phylogenetic tree and Reactive oxygen species, Cell biology. His work carried out in the field of Cell biology brings together such families of science as Mutagenesis and Sulfiredoxin.
His work in Cysteine addresses issues such as Peroxide, which are connected to fields such as Hydrogen peroxide, Catalytic cycle and Sulfenic acid. His research integrates issues of Peroxidase, Stereochemistry and Oxidoreductase in his study of Active site. His studies in Redox integrate themes in fields like Biophysics and Thiol.
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Structure, mechanism and regulation of peroxiredoxins
Zachary A Wood;Ewald Schröder;J Robin Harris;Leslie B Poole.
Trends in Biochemical Sciences (2003)
Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling
Zachary A. Wood;Leslie B. Poole;P. Andrew Karplus.
Science (2003)
Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.
Ho Zoon Chae;Keith Robison;Leslie B. Poole;George Church.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Protein Sulfenic Acids in Redox Signaling
Leslie B. Poole;P. Andrew Karplus;Al Claiborne.
Annual Review of Pharmacology and Toxicology (2004)
The basics of thiols and cysteines in redox biology and chemistry
Leslie B. Poole.
Free Radical Biology and Medicine (2015)
Typical 2-Cys Peroxiredoxins: Structures, mechanisms and functions
Andrea Hall;P. A. Karplus;Leslie B. Poole.
FEBS Journal (2009)
Discovering mechanisms of signaling-mediated cysteine oxidation
Leslie B Poole;Kimberly J Nelson.
Current Opinion in Chemical Biology (2008)
Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
Zachary A. Wood;Leslie B. Poole;Roy R. Hantgan;P. Andrew Karplus.
Biochemistry (2002)
Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.
Arden Perkins;Kimberly J. Nelson;Derek Parsonage;Leslie B. Poole.
Trends in Biochemical Sciences (2015)
Cysteine-based redox switches in enzymes.
Chananat Klomsiri;P. Andrew Karplus;Leslie B. Poole.
Antioxidants & Redox Signaling (2011)
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