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Chemistry

D-Index
72
Citations
22057
World Ranking
5187
National Ranking
1613

Biology and Biochemistry

D-Index
72
Citations
22174
World Ranking
6197
National Ranking
2915

Overview

Leslie B. Poole is affiliated with Wake Forest University in the United States. Their research primarily focuses on biochemical processes within molecular biology, with a significant emphasis on redox biology and oxidative stress.

The main fields of study covered in Leslie B. Poole's research include:

  • Biochemistry, Genetics and Molecular Biology

The subfields in which they have contributed are:

  • Molecular Biology
  • Biochemistry
  • Physiology
  • Biophysics
  • Nutrition and Dietetics

Leslie B. Poole's work spans multiple topics, demonstrating a broad range of interests relevant to biochemical and cellular signaling processes. These topics include:

  • Redox biology and oxidative stress
  • Sulfur Compounds in Biology
  • Electron Spin Resonance Studies
  • Protein Kinase Regulation and GTPase Signaling
  • Protein Structure and Dynamics
  • Melanoma and MAPK Pathways
  • Immune cells in cancer

Frequent publication venues for Leslie B. Poole include:

  • Free Radical Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Redox Biology
  • The FASEB Journal
  • Nature Cell Biology

The scientist has collaborated extensively with several co-authors, who have contributed to multiple projects alongside them. These frequent co-authors are:

  • Cristina M. Furdui
  • Derek Parsonage
  • Robert H. Newman
  • Hanzhi Wu
  • Jingyun Lee

Representative recent publications highlight the scope of Leslie B. Poole's research. These include:

  • "Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis" (2022), published in Nature Cell Biology
  • "Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes" (2021), published in Free Radical Biology and Medicine
  • "Introduction to approaches and tools for the evaluation of protein cysteine oxidation" (2020), published in Essays in Biochemistry
  • "Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug" (2022), published in Redox Biology
  • "Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity" (2022), published in Proceedings of the National Academy of Sciences

Best Publications

  • Structure, mechanism and regulation of peroxiredoxins

    Zachary A Wood;Ewald Schröder;J Robin Harris;Leslie B Poole

  • Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

    Zachary A. Wood;Leslie B. Poole;Leslie B. Poole;P. Andrew Karplus;P. Andrew Karplus

  • The basics of thiols and cysteines in redox biology and chemistry.

    Leslie B. Poole

  • Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

    Ho Zoon Chae;Keith Robison;Leslie B. Poole;George Church

  • Protein Sulfenic Acids in Redox Signaling

    Leslie B Poole;P Andrew Karplus;Al Claiborne

  • Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.

    Arden Perkins;Kimberly J. Nelson;Derek Parsonage;Leslie B. Poole

  • Typical 2-Cys Peroxiredoxins: Structures, mechanisms and functions

    Andrea Hall;P. A. Karplus;Leslie B. Poole

  • Discovering mechanisms of signaling-mediated cysteine oxidation

    Leslie B Poole;Kimberly J Nelson

  • Cysteine-based redox switches in enzymes.

    Chananat Klomsiri;P. Andrew Karplus;Leslie B. Poole

  • Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.

    Zachary A. Wood;Leslie B. Poole;Roy R. Hantgan;P. Andrew Karplus

  • Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.

    Andrea Hall;Kimberly Nelson;Leslie B. Poole;P. Andrew Karplus

  • A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

    Anjan Debnath;Derek Parsonage;Rosa M. Andrade;Chen-chen He

  • Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases ☆

    Leslie B. Poole

  • Novel application of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole to identify cysteine sulfenic acid in the AhpC component of alkyl hydroperoxide reductase.

    Holly R. Ellis;Leslie B. Poole

  • Flavin-Dependent Alkyl Hydroperoxide Reductase from Salmonella typhimurium. 1. Purification and Enzymatic Activities of Overexpressed AhpF and AhpC Proteins†

    Leslie B. Poole;Holly R. Ellis

  • Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium

    Holly R. Ellis;Leslie B. Poole

  • Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization

    Laura M. S. Baker;Ausra Raudonikiene;Paul S. Hoffman;Leslie B. Poole

  • Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin

    Derek Parsonage;Derek S. Youngblood;Ganapathy N. Sarma;Zachary A. Wood

  • Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization

    Andrea Hall;Derek Parsonage;Leslie B. Poole;P. Andrew Karplus

  • Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin

    Derek Parsonage;P. Andrew Karplus;Leslie B. Poole

Frequent Co-Authors

P. Andrew Karplus
P. Andrew Karplus Oregon State University
S. Bruce King
S. Bruce King Wake Forest University
Richard F. Loeser
Richard F. Loeser University of North Carolina at Chapel Hill
Floyd H. Chilton
Floyd H. Chilton University of Arizona
Ana Denicola
Ana Denicola University of the Republic
Sharon L. Reed
Sharon L. Reed University of California, San Diego
Tohru Fukai
Tohru Fukai Veterans Health Administration
Susan M. Hutson
Susan M. Hutson Virginia Tech
Yoshimasa Nakamura
Yoshimasa Nakamura Okayama University
Yoshiyuki Kamio
Yoshiyuki Kamio Tohoku University

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