World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
29828
World Ranking
3448
National Ranking
1736

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1996 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

P. Andrew Karplus is affiliated with Oregon State University in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology. Additional areas of study include Radiology, Nuclear Medicine and Imaging, Organic Chemistry, Biophysics, and Oncology.

The scientist's work covers several main topics, including RNA and protein synthesis mechanisms, RNA modifications and cancer, monoclonal and polyclonal antibodies research, chemical synthesis and analysis, genomics and phylogenetic studies, ubiquitin and proteasome pathways, and redox biology and oxidative stress.

Among their recent publications are:

  • Overcoming Near-Cognate Suppression in a Release Factor 1-Deficient Host with an Improved Nitro-Tyrosine tRNA Synthetase, 2020, Journal of Molecular Biology
  • Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ, 2023, ACS Central Science
  • Site-specific dual encoding and labeling of proteins via genetic code expansion, 2023, Cell Chemical Biology
  • Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids, 2022, ACS Chemical Biology
  • Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2, 2021, Journal of Biological Chemistry

P. Andrew Karplus frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), ACS Chemical Biology, Journal of Biological Chemistry, Journal of the American Chemical Society, and Biophysical Journal.

The scientist has collaborated extensively with colleagues including Ryan A. Mehl, Richard B. Cooley, Subhashis Jana, Riley M. Bednar, and Patrick N. Reardon.

Throughout their career, P. Andrew Karplus has received recognition in the form of several awards, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2014 and a Fellow of the John Simon Guggenheim Memorial Foundation in 1996.

Best Publications

  • Linking crystallographic model and data quality.

    P. Andrew Karplus;Kay Diederichs

  • Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

    Zachary A. Wood;Leslie B. Poole;Leslie B. Poole;P. Andrew Karplus;P. Andrew Karplus

  • Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin

    Gregory D. Van Duyne;Robert F. Standaert;P.Andrew Karplus;Stuart L. Schreiber

  • Improved R-factors for diffraction data analysis in macromolecular crystallography

    Kay Diederichs;P. Andrew Karplus

  • The crystal structure of urease from Klebsiella aerogenes

    E Jabri;MB Carr;RP Hausinger;PA Karplus

  • Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

    GD Van Duyne;RF Standaert;PA Karplus;SL Schreiber

  • Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain

    Matthew A. Pearson;David Reczek;Anthony Bretscher;P.Andrew Karplus;P.Andrew Karplus

  • Protein Sulfenic Acids in Redox Signaling

    Leslie B Poole;P Andrew Karplus;Al Claiborne

  • Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.

    Arden Perkins;Kimberly J. Nelson;Derek Parsonage;Leslie B. Poole

  • Refined structure of glutathione reductase at 1.54 A resolution.

    P.A Karplus;G.E. Schulz

  • A Novel Mechanism of Chemoprotection by Sulforaphane: Inhibition of Histone Deacetylase

    Melinda C. Myzak;P. Andrew Karplus;Fung-Lung Chung;Roderick H. Dashwood

  • Typical 2-Cys Peroxiredoxins: Structures, mechanisms and functions

    Andrea Hall;P. A. Karplus;Leslie B. Poole

  • Cysteine-based redox switches in enzymes.

    Chananat Klomsiri;P. Andrew Karplus;Leslie B. Poole

  • Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.

    Zachary A. Wood;Leslie B. Poole;Roy R. Hantgan;P. Andrew Karplus

  • Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.

    Andrea Hall;Kimberly Nelson;Leslie B. Poole;P. Andrew Karplus

  • Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution.

    P A Karplus;G E Schulz

  • A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins.

    Scott A. Hollingsworth;P. Andrew Karplus

  • Refined structure of porcine cytosolic adenylate kinase at 2.1 Å resolution

    D Dreusicke;P.A Karplus;G.E. Schulz

  • Crystal structure of thermostable family 5 endocellulase E1 from Acidothermus cellulolyticus in complex with cellotetraose.

    J Sakon;W.S Adney;M.E Himmel;S.R Thomas

  • Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.

    Kay Diederichs;Tom Boone;P. Andrew Karplus

Frequent Co-Authors

Leslie B. Poole
Leslie B. Poole Wake Forest University
Kay Diederichs
Kay Diederichs University of Konstanz
Anthony Bretscher
Anthony Bretscher Cornell University
Martha H. Stipanuk
Martha H. Stipanuk Cornell University
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Roland L. Dunbrack
Roland L. Dunbrack Fox Chase Cancer Center
Robert P. Hausinger
Robert P. Hausinger Michigan State University
Daniel J. Arp
Daniel J. Arp Oregon State University
Paul D. Adams
Paul D. Adams Lawrence Berkeley National Laboratory
Katja Becker
Katja Becker University of Giessen

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