Scott A. Lesley

Overview

Best Publications

• Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

  William R. Wikoff;Andrew T. Anfora;Jun Liu;Peter G. Schultz

  2920
  Citations

• Protein production and purification.

  S Gräslund

  1004
  Citations

• Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline

  Scott A. Lesley;Peter Kuhn;Adam Godzik;Ashley M. Deacon

  511
  Citations

• Co-regulatory networks of human serum proteins link genetics to disease

  Valur Emilsson;Marjan Ilkov;John R. Lamb;Nancy Finkel

  492
  Citations

• Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts

  Heath E. Klock;Eric J. Koesema;Mark W. Knuth;Scott A. Lesley

  407
  Citations

• The Polymerase Incomplete Primer Extension (PIPE) Method Applied to High-Throughput Cloning and Site-Directed Mutagenesis

  Heath E. Klock;Scott A. Lesley

  400
  Citations

• XtalPred: a web server for prediction of protein crystallizability.

  Lukasz Slabinski;Lukasz Jaroszewski;Leszek Rychlewski;Ian A. Wilson

  360
  Citations

• High throughput processing system and method of using

  Kristina Marie Burow;Jeremy S. Caldwell;Robert Charles Downs;Scott Allan Lesley

  345
  Citations

• Size and Shape of Detergent Micelles Determined by Small-Angle X-ray Scattering

  Jan Lipfert;Linda Columbus;Vincent B Chu;Scott A Lesley

  291
  Citations

• Use of in vitro protein synthesis from polymerase chain reaction-generated templates to study interaction of Escherichia coli transcription factors with core RNA polymerase and for epitope mapping of monoclonal antibodies.

  S. A. Lesley;M. A. D. Brow;R. R. Burgess

  262
  Citations

• Crystal Structure of a Divalent Metal Ion Transporter CorA at 2.9 Angstrom Resolution

  Said Eshaghi;Damian Niegowski;Damian Niegowski;Andreas Kohl;Daniel Martinez Molina;Daniel Martinez Molina

  246
  Citations

• High-throughput proteomics: protein expression and purification in the postgenomic world.

  Scott A. Lesley

  239
  Citations

• The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.

  Eric N. Hampton;Mark W. Knuth;Jun Li;Jennifer L. Harris

  225
  Citations

• Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

  Christian C. Lee;Yong Jia;Nanxin Li;Xiuying Sun

  225
  Citations

• Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima

  Ying Zhang;Ines Thiele;Dana Weekes;Zhanwen Li

  217
  Citations

• The challenge of protein structure determination--lessons from structural genomics.

  Lukasz Slabinski;Lukasz Jaroszewski;Ana P.C. Rodrigues;Leszek Rychlewski

  210
  Citations

• Characterization of the Escherichia coli transcription factor sigma 70: localization of a region involved in the interaction with core RNA polymerase.

  Scott A. Lesley;Richard R. Burgess

  200
  Citations

• Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.

  Jun Li;Christine Tumanut;Julie-Ann Gavigan;Waan-Jeng Huang

  187
  Citations

• Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

  Magdalena Mazagova;Lirui Wang;Andrew T. Anfora;Max Wissmueller

  183
  Citations

• Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS

  Dennis Pantazatos;Jack S. Kim;Heath E. Klock;Raymond C. Stevens

  179
  Citations