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Biology and Biochemistry

D-Index
58
Citations
13789
World Ranking
13073
National Ranking
5574

Overview

Youngchang Kim is affiliated with Argonne National Laboratory in the United States. Their research contributions primarily lie at the intersection of biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular biology and infectious diseases.

The scientist has published extensively on a range of topics, including enzyme structure and function, RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, antibiotic resistance in bacteria, SARS-CoV-2 and COVID-19 research, Vibrio bacteria studies, and protein structure and dynamics.

Frequent co-authors in their publications include A. Joachimiak, K. Michalska, R. Jedrzejczak, N. Maltseva, and M. Endres.

Youngchang Kim's research has appeared in several notable publication venues. The most frequent journals and platforms include bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Acta Crystallographica Section A Foundations and Advances, Nature Communications, and Proteins Structure Function and Bioinformatics.

Selected recent papers illustrate the scientist's focus on structural biology related to coronavirus research and enzymology:

  • "Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors," 2021, published in Nature Communications
  • "Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV -2," 2020, published in Protein Science
  • "Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes," 2020, published in IUCrJ
  • "Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2," 2021, published in Communications Biology
  • "Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Crystal structure of a yeast TBP/TATA-box complex.

    Youngchang Kim;James. H. Geiger;Steven Hahn;Paul B. Sigler

  • Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

    Wolfgang Fischle;Yanming Wang;Steven A. Jacobs;Youngchang Kim

  • Protein production and purification.

    S Gräslund

  • Double chromodomains cooperate to recognize the methylated histone H3 tail

    John F. Flanagan;Li-Zhi Mi;Maksymilian Chruszcz;Marcin Cymborowski

  • Refinement of Eco RI endonuclease crystal structure: a revised protein chain tracing.

    Youngchang Kim;John C. Grable;Robert Love;Patricia J. Greene

  • Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.

    Jerzy Osipiuk;Jerzy Osipiuk;Saara Anne Azizi;Steve Dvorkin;Michael Endres;Michael Endres

  • Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

    Pengxiang Huang;Daniel Nedelcu;Miyako Watanabe;Cindy Jao

  • Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.

    Youngchang Kim;Youngchang Kim;Robert Jedrzejczak;Robert Jedrzejczak;Natalia I. Maltseva;Natalia I. Maltseva;Mateusz Wilamowski

  • Structural integration in hypoxia-inducible factors

    Dalei Wu;Nalini Potluri;Jingping Lu;Youngchang Kim

  • Multidomain integration in the structure of the HNF-4α nuclear receptor complex

    Vikas Chandra;Pengxiang Huang;Nalini Potluri;Dalei Wu

  • Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

    Changwook Lee;BumSoo Hong;Jung Min Choi;Yugene Kim

  • Structural Basis of Smoothened Activation in Hedgehog Signaling.

    Pengxiang Huang;Sanduo Zheng;Bradley M. Wierbowski;Youngchang Kim

  • The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

    David H. Sherman;Shengying Li;Liudmila V. Yermalitskaya;Youngchang Kim

  • High-throughput protein purification and quality assessment for crystallization.

    Youngchang Kim;Gyorgy Babnigg;Gyorgy Babnigg;Robert Jedrzejczak;William H. Eschenfeldt

  • The active site of the SET domain is constructed on a knot.

    Steven A Jacobs;Joel M Harp;Srikripa Devarakonda;Youngchang Kim

  • Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9—AdoMet

    Taewoo Kwon;Jeong Ho Chang;Eunyee Kwak;Chang Wook Lee

  • Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica

    Michael Kube;Tatyana N. Chernikova;Yamal Al-Ramahi;Ana Beloqui

  • NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism

    Youngchang Kim;Mark A. Cunningham;Joseph Mire;Christine Tesar

  • Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.

    Youngchang Kim;Christine Tesar;Joseph Mire;Robert Jedrzejczak

  • Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

    Jerzy Osipiuk;Jerzy Osipiuk;Saara-Anne Azizi;Steve Dvorkin;Michael Endres;Michael Endres

Frequent Co-Authors

Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Alexei Savchenko
Alexei Savchenko University of Calgary
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Sean Crosson
Sean Crosson University of Chicago
Lizbeth Hedstrom
Lizbeth Hedstrom Brandeis University
David H. Sherman
David H. Sherman University of Michigan–Ann Arbor
Rongguang Zhang
Rongguang Zhang Chinese Academy of Sciences
Gregory D. Cuny
Gregory D. Cuny University of Houston
George N. Phillips
George N. Phillips Rice University

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