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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
11603
World Ranking
14408
National Ranking
6067

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Lizbeth Hedstrom is affiliated with Brandeis University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in molecular biology, epidemiology, and infectious diseases.

Their work encompasses various specialized subfields including molecular biology, epidemiology, infectious diseases, parasitology, and spectroscopy. This broad scope is reflected in their engagement with topics such as biochemical and molecular research, HIV/AIDS drug development and treatment, cytomegalovirus and herpesvirus research, Pneumocystis jirovecii pneumonia detection and treatment, tuberculosis research and epidemiology, Mycobacterium research and diagnosis, and protein structure and dynamics.

Lizbeth Hedstrom has authored multiple scientific papers, contributing to journals in notable publication venues. Some of their recent papers include:

  • "Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4", 2022, published in Cell Chemical Biology
  • "Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors", 2020, published in Bioorganic & Medicinal Chemistry Letters
  • "The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections", 2021, published in ACS Infectious Diseases
  • "A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis", 2022, published in ACS Infectious Diseases
  • "Mechanism of Inhibitor Selectivity Revealed by Mutagenesis and pre-Steady-State Studies", 2021, published in The FASEB Journal

The frequent publication venues for their work include:

  • Bioorganic & Medicinal Chemistry Letters
  • ACS Infectious Diseases
  • Cell Chemical Biology
  • The FASEB Journal
  • Biochemistry

Lizbeth Hedstrom collaborates regularly with several researchers, including:

  • Gregory D. Cuny
  • Xingyou Wang
  • Shibin Chacko
  • Deviprasad R. Gollapalli
  • Michael J. Pepi

Among their recognitions, Lizbeth Hedstrom was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Serine protease mechanism and specificity

    Lizbeth Hedstrom

  • A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

    William Checkley;William Checkley;A. Clinton White;Devan Jaganath;Michael J. Arrowood

  • IMP dehydrogenase: structure, mechanism, and inhibition.

    Lizbeth Hedstrom

  • Gene transfer in the evolution of parasite nucleotide biosynthesis

    Boris Striepen;Andrea J. P. Pruijssers;Jinling Huang;Catherine Li

  • Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.

    Sara J. Bowne;Lori S. Sullivan;Sarah E. Mortimer;Lizbeth Hedstrom

  • A twisted base? The role of arginine in enzyme-catalyzed proton abstractions

    Yollete V. Guillén Schlippe;Lizbeth Hedstrom

  • Structural origins of substrate discrimination in trypsin and chymotrypsin

    John J. Perona;Lizbeth Hedstrom;William J. Rutter;Robert J. Fletterick

  • Converting Trypsin to Chymotrypsin: Residue 172 Is a Substrate Specificity Determinant

    Lizbeth Hedstrom;John J. Perona;William J. Rutter

  • Suicide inactivation of chymotrypsin by benzoxazinones.

    Lizbeth Hedstrom;Allan R. Moorman;Jeffrey Dobbs;Robert H. Abeles

  • Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi

    Bryce E. Mansfield;Hanna N. Oltean;Brian G. Oliver;Samantha J. Hoot

  • Hydrophobic Interactions Control Zymogen Activation in the Trypsin Family of Serine Proteases

    Lizbeth Hedstrom;Tiao Yin Lin;Walter L Fast;Walter L Fast

  • IMP dehydrogenase: mechanism of action and inhibition.

    Hedstrom L

  • Cryptosporidium parvum IMP Dehydrogenase IDENTIFICATION OF FUNCTIONAL, STRUCTURAL, AND DYNAMIC PROPERTIES THAT CAN BE EXPLOITED FOR DRUG DESIGN

    Nwakaso N. Umejiego;Catherine Li;Thomas Riera;Lizbeth Hedstrom

  • Multiple Inhibitor Analysis of the Brequinar and Leflunomide Binding Sites on Human Dihydroorotate Dehydrogenase

    Jeremy E. McLean;Edie A. Neidhardt;Trudy H. Grossman;Lizbeth Hedstrom

  • Inhibitor Mediated Protein Degradation

    Marcus J.C. Long;Deviprasad R. Gollapalli;Lizbeth Hedstrom

  • Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

    Jeremy E McLean;Nobuko Hamaguchi;Peter Belenky;Sarah E Mortimer

  • Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles.

    Volker Schellenberger;Christoph W. Turck;Lizbeth Hedstrom;William J. Rutter

  • TRYPSIN : A CASE STUDY IN THE STRUCTURAL DETERMINANTS OF ENZYME SPECIFICITY

    Hedstrom L

  • 3-Deoxy-D-manno-octulosonate-8-phosphate synthase catalyzes the C-O bond cleavage of phosphoenolpyruvate.

    Lizbeth Hedstrom;Robert Abeles

  • Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

    Nwakaso N. Umejiego;Deviprasad Gollapalli;Lisa Sharling;Anna Volftsun

Frequent Co-Authors

Gregory D. Cuny
Gregory D. Cuny University of Houston
Boris Striepen
Boris Striepen University of Pennsylvania
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Youngchang Kim
Youngchang Kim Argonne National Laboratory
William J. Rutter
William J. Rutter University of California, San Francisco
Bing Xu
Bing Xu Brandeis University
Joanna B. Goldberg
Joanna B. Goldberg Emory University
Stephen P. Daiger
Stephen P. Daiger The University of Texas Health Science Center at Houston
Robert H. Abeles
Robert H. Abeles Brandeis University
Mary F. Roberts
Mary F. Roberts Boston College

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