2010 - Fellow of the American Association for the Advancement of Science (AAAS)
Her main research concerns Biochemistry, Stereochemistry, Enzyme, Chymotrypsin and Trypsin. Biochemistry and IMP dehydrogenase are frequently intertwined in her study. Her research integrates issues of Biosynthesis, Cryptosporidium parvum, Antimicrobial chemotherapy, Dehydrogenase and NAD+ kinase in her study of IMP dehydrogenase.
Her Stereochemistry study integrates concerns from other disciplines, such as Residue, Covalent bond, Arginine, Isothermal titration calorimetry and Binding site. The Chymotrypsin study combines topics in areas such as Amino acid, Protease, Hydrolysis, Peptide sequence and Substrate. Her Trypsin research incorporates themes from Protein structure, Enzyme catalysis and Benzamidine.
Lizbeth Hedstrom mostly deals with Biochemistry, IMP dehydrogenase, Enzyme, Stereochemistry and Inosine. Her research combines Cryptosporidium parvum and Biochemistry. Her study explores the link between IMP dehydrogenase and topics such as NAD+ kinase that cross with problems in Transition state analog, Oxidoreductase and Covalent bond.
Lizbeth Hedstrom has researched Enzyme in several fields, including Function, Penicillium and Antimicrobial chemotherapy. Her Stereochemistry research incorporates elements of Cofactor, Substrate, Enzyme kinetics, Trypsin and Active site. Her Inosine study incorporates themes from Xanthosine and Structure–activity relationship.
Lizbeth Hedstrom focuses on Biochemistry, Enzyme, Cell biology, IMP dehydrogenase and Catalytic cycle. Her study in Cryptosporidium parvum extends to Biochemistry with its themes. Her study in Enzyme is interdisciplinary in nature, drawing from both Microbiology and Virulence.
Her studies deal with areas such as Metabolic pathway, Function and Drug discovery as well as IMP dehydrogenase. She interconnects Substrate, Stereochemistry and Cofactor in the investigation of issues within Catalytic cycle. Her Stereochemistry research includes themes of Xanthosine and Ternary complex.
The scientist’s investigation covers issues in Biochemistry, Cell biology, Mycobacterium tuberculosis, Virulence and Microbiology. Her study ties her expertise on Cryptosporidium parvum together with the subject of Biochemistry. In the subject of general Cell biology, her work in Proteasome, Protein degradation and mTORC1 is often linked to Ubiquilin-2, thereby combining diverse domains of study.
Her Mycobacterium tuberculosis research overlaps with Dehydrogenase, Benzoxazole, Inosine-5′-monophosphate dehydrogenase, Biosynthesis and Inosine. Lizbeth Hedstrom interconnects IMP dehydrogenase, Tularemia, Mutant and Enzyme in the investigation of issues within Virulence. Her Microbiology research is multidisciplinary, relying on both Francisella tularensis, Structure–activity relationship and DNA ligase.
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Serine protease mechanism and specificity.
Chemical Reviews (2002)
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium
William Checkley;William Checkley;A. Clinton White;Devan Jaganath;Michael J. Arrowood.
Lancet Infectious Diseases (2015)
IMP dehydrogenase: structure, mechanism, and inhibition.
Chemical Reviews (2009)
Gene transfer in the evolution of parasite nucleotide biosynthesis
Boris Striepen;Andrea J. P. Pruijssers;Jinling Huang;Catherine Li.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.
Sara J. Bowne;Lori S. Sullivan;Sarah E. Mortimer;Lizbeth Hedstrom.
Investigative Ophthalmology & Visual Science (2006)
A twisted base? The role of arginine in enzyme-catalyzed proton abstractions
Yollete V. Guillén Schlippe;Lizbeth Hedstrom.
Archives of Biochemistry and Biophysics (2005)
Structural origins of substrate discrimination in trypsin and chymotrypsin
John J. Perona;Lizbeth Hedstrom;William J. Rutter;Robert J. Fletterick.
Converting Trypsin to Chymotrypsin: Residue 172 Is a Substrate Specificity Determinant
Lizbeth Hedstrom;John J. Perona;William J. Rutter.
Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi
Bryce E. Mansfield;Hanna N. Oltean;Brian G. Oliver;Samantha J. Hoot.
PLOS Pathogens (2010)
Hydrophobic Interactions Control Zymogen Activation in the Trypsin Family of Serine Proteases
Lizbeth Hedstrom;Tiao Yin Lin;Tiao Yin Lin;Walter L Fast;Walter L Fast.
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