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Molecular Biology

D-Index
64
Citations
21600
World Ranking
1708
National Ranking
2

Overview

Wolfgang Fischle is affiliated with King Abdullah University of Science and Technology in Saudi Arabia. Their research primarily focuses on biochemical and molecular biology aspects, with a strong emphasis on genetics.

The main fields of study in their work include:

  • Biochemistry, Genetics and Molecular Biology

More specific subfields addressed are:

  • Molecular Biology
  • Genetics
  • Public Health, Environmental and Occupational Health
  • Virology
  • Immunology

The key research topics covered in their publications are:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Ubiquitin and proteasome pathways

Wolfgang Fischle has contributed to several recent scientific papers, including:

  • "Elevated NSD3 histone methylation activity drives squamous cell lung cancer" (2021, Nature)
  • "NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis" (2021, Molecular Cell)
  • "Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry" (2020, Nature Communications)
  • "DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages" (2023, Nature Microbiology)
  • "Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes" (2020, Chemical Science)

Frequent collaborators in their research include:

  • Vladlena Kharchenko
  • Łukasz Jaremko
  • Zhadyra Yerkesh
  • Dulat M. Azhibek
  • Karthik Eswara

Their work has been published in various scientific venues, notably:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Molecular Cell
  • Nature Microbiology

Best Publications

  • Histone and chromatin cross-talk.

    Wolfgang Fischle;Yanming Wang;C David Allis

  • Duration of nuclear NF-κB action regulated by reversible acetylation

    Lin-feng Chen;Wolfgang Fischle;Eric Verdin;Warner C. Greene

  • Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

    Wolfgang Fischle;Yanming Wang;Steven A. Jacobs;Youngchang Kim

  • Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation

    Wolfgang Fischle;Boo Shan Tseng;Holger L. Dormann;Beatrix M. Ueberheide

  • Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

    Wolfgang Fischle;Franck Dequiedt;Michael J Hendzel;Matthew G Guenther

  • Binary switches and modification cassettes in histone biology and beyond.

    Wolfgang Fischle;Yanming Wang;C. David Allis

  • Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

    Frank W. Schmitges;Archana B. Prusty;Mahamadou Faty;Alexandra Stützer

  • BCoR, a novel corepressor involved in BCL-6 repression

    Khanh D. Huynh;Wolfgang Fischle;Eric Verdin;Vivian J. Bardwell

  • A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.

    Matthew G. Guenther;William S. Lane;Wolfgang Fischle;Eric Verdin

  • Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.

    Karin J. Ferrari;Andrea Scelfo;SriGanesh Jammula;Alessandro Cuomo

  • Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties.

    Konstantinos Tenidis;Michaela Waldner;Jürgen Bernhagen;Wolfgang Fischle

  • A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities

    Tetyana Klymenko;Bernadett Papp;Wolfgang Fischle;Thomas Köcher

  • TRIM24 links a non-canonical histone signature to breast cancer

    Wen Wei Tsai;Zhanxin Wang;Teresa T. Yiu;Teresa T. Yiu;Kadir C. Akdemir

  • Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.

    Yingying Zhang;Renata Jurkowska;Szabolcs Soeroes;Arumugam Rajavelu

  • Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

    Ke Zhang;Kerstin Mosch;Wolfgang Fischle;Shiv I S Grewal

  • Characterization of a human RPD3 ortholog, HDAC3

    S. Emiliani;W. Fischle;C. Van Lint;Y. Al-Abed

  • Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

    Melanie Ott;Martina Schnölzer;Jerry Garnica;Wolfgang Fischle

  • The Nucleation and Maintenance of Heterochromatin by a Histone Deacetylase in Fission Yeast

    Takatomi Yamada;Wolfgang Fischle;Tomoyasu Sugiyama;C. David Allis

  • A NEW FAMILY OF HUMAN HISTONE DEACETYLASES RELATED TO SACCHAROMYCES CEREVISIAE HDA1P

    Wolfgang Fischle;Stephane Emiliani;Michael J. Hendzel;Takahiro Nagase

  • Control of cytomegalovirus lytic gene expression by histone acetylation.

    Jane C. Murphy;Wolfgang Fischle;Eric Verdin;John H. Sinclair

Frequent Co-Authors

Dirk Schwarzer
Dirk Schwarzer Max Planck Society
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
C. David Allis
C. David Allis Rockefeller University
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Henning Urlaub
Henning Urlaub University of Göttingen
Yanming Wang
Yanming Wang Shanghai Jiao Tong University
Michael J. Hendzel
Michael J. Hendzel University of Alberta
Diego Pasini
Diego Pasini European Institute of Oncology
Yang Shi
Yang Shi University of Oxford
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center

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